Long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) was widely recognized to be implicated in human cancer, vascular diseases, and neurological disorders. This study explore the role underlying mechanism of MALAT1 acute spinal cord injury (ASCI). ASCI models adult rats were established demonstrated by a numerical decrease BBB scores. Expression profile miR-199b following vitro determined using quantitative real-time PCR. pull-down assays combined with...

Objective: To investigate the correlation between uterine volume and intrauterine adhesion (IUA). Methods: From June 2018 to November 2019, totally 7 007 patients who underwent hysteroscopy in outpatient operating rooms of Gynecological Minimally Invasive Center, Beijing Obstetrics Gynecology Hospital were retrospectively analyzed. Patients reproductive age with IUA without fibroids adenomyosis selected as group, during same period control group. The propensity score matching (PSM) method...

Abstract Purpose: Glioblastoma (GBM) is a highly vascularized tumor with few treatment options after disease recurrence. Here, we report the efficacy and safety of anlotinib hydrochloride plus temozolomide in patients recurrent GBM. Patients Methods: first definite postsurgical progression histologically confirmed GBM preceded by standard radiotherapy chemotherapy were eligible for inclusion. All received (150–200 mg/m2, orally, every day (QD) d1–5/4 wk) (10 mg, QD, d1–14/3 until or...

Abstract The blood‐brain barrier (BBB) damage is a momentous pathological process of ischaemic stroke. NADPH oxidases 4 (NOX4) boosts BBB after stroke and its expression can be influenced by microRNAs. This study aimed to probe into whether miR‐92b the regulating NOX4 expression. Here, was lessened in brains rats oxygen‐glucose deprivation (OGD)‐induced brain microvascular endothelial cells (BMECs). In middle cerebral artery occlusion (MCAo) rats, overexpression relieved ameliorated...

Cerebral aneurysms follows atrial myxoma is a rare neurological complication. We report patient with multiple cerebral three years after resection of left and further review the literature. The characteristics these are indefinite variable. They can occur prior or post cardiac myxoma. "Metastasize Infiltrate" theory may be key mechanism in formation aneurysms. Magnetic resonance imaging (MRI), computed tomography (CT) angiography useful diagnosis while digital subtraction (DSA) best choice....

The present study investigated the therapeutic effects and indications of keyhole transsylvian approach (KTA) in treatment hypertensive intracerebral hemorrhage (HICH). Clinical data 65 cases HICH were retrospectively analyzed. All patients treated by open surgical evacuation either through KTA (KTA group) or conventional craniotomy (CCA group). operative time, intraoperative bleeding quantity, length hospitalization, mortality, favorable outcome compared between 2 groups. Compared with CCA...

The authors evaluated the results of Gamma knife surgery (GKS) for treatment metastatic brain tumors from hepatocellular carcinoma (HCC).The conducted a retrospective review clinical characteristics and outcomes in 14 patients with HCC who underwent GKS. Twelve (85.7%) were male. mean age was 53±12 years. There totally 22 metastases 8 (57.1%) presented single lesion. Intracranial hemorrhages occurred 13 (59.1%) lesions. KPS score 81±14 (range 50-100). Eleven (78.6%) classified as RTOG RPA...

Abstract Hepatitis B virus (HBV) is the main causative viral agent for liver diseases in China. In injury, exosomes may impede interaction with chromatin target cell and transmit inflammatory, apoptosis, or regeneration signals through RNAs. Therefore, we attempted to determine potential functions of exosomal RNAs using bioinformatics technology. We performed RNA sequencing analysis derived from clinical specimens healthy control (HC) individuals patients chronic hepatitis (CHB)...

Brain nocardiosis is a serious opportunistic infection with high mortality. It exists more common in the immunocompromised hosts than immunocompetent patients. Trimethoprim-sulfamethoxazole (TMP-SMZ) has been mostly considered as choice of medical treatment. Linezolid also newly found to be effective avoid invasive surgery. The authors reported case patient multifoci nocardial brain abscesses who failed combination linezolid and TMP-SMZ alone but recovered surgery intervention sequential...

The present retrospective study aimed to analyze the outcome of patients with cavernous sinus hemangioma (CSH) treated Gamma Knife radiosurgery (GKS). Between August 2011 and April 2014, 7 CSHs underwent GKS. GKS was performed as sole treatment option in 5 patients, whilst partial resection had been previously 1 patient biopsy patient. mean volume tumors at time 12.5±10.2 cm3 (range, 5.3-33.2 cm3), median prescription peripheral dose 14.0 Gy 10.0-15.0 Gy). follow-up period 20 months 6-40...

Myofibroblastoma is a benign tumor composed of spindle cells in clusters and fascicles. To date, only three cases intracranial myofibroblastoma have been reported. The present study reports the case 47-year-old female with meningeal myofibroblastoma. patient had history ovarian cyst resection presented paroxysmal mild headaches that apparent for 4 years. Magnetic resonance imaging disclosed well-circumscribed mass left frontal lobe. A was performed. Abundant fascicular spindle- oval-shaped...

Radiofrequency ablation (RFA) of lung tumours has recently received much attention for the promising results achieved. Here, to evaluate value three-dimensional reconstruction CT in radiofrequency advanced non-small cell cancer. Sixty-six cases cancer with 68 lesions (2 patients had 2 lesion treated one session) were underwent CT-giuded percutaneous RFA therapy. To short-term therapeutic effect tumors using spiral scanning 1-3 months after investigate alterations tumor size and density...

Background: Radiation necrosis is one of the complications Gammaknife radiosurgery. The traditional treatment radiation carries a high risk failure, Bevacizumab an antiangiogenic monoclonal antibody against vascular endothelial growth factor, known mediator cerebral edema. It can be used to successfully treat brain necrosis. Patient Description: Two patients with history small cell lung cancer presented metastatic disease brain. They underwent radiosurgery metastases. Several months later,...

Two patients presented with rare isolated recurrence of granulocytic sarcoma. A 29-year-old male an extra- and intracranial mass 10 years after bone marrow transplantation for chronic myeloid leukemia. 34-year-old female 3 complete remission acute leukemia-M2a. Both underwent surgical resection. The first patient received adequate postoperative radiotherapy chemotherapy, achieved without evidence diseases during the 6-month follow up. second only whole brain radiotherapy, failed to respond,...

Hemophilic pseudotumor is a rare but well-known complication of hemophilia manifesting as recurrent hemorrhage and progressive enlargement hematoma. A patient with severe has 1% to 2% chance develop pseudotumor. The chronic pressure osseous usually results in bone destruction or resorption. Cranial hemophilic pseudotumors are extremely rare, only 7 reported cases associated mild moderate factor VIII IX deficiency. 42-year-old man deficiency developed the bilateral skull. Computed tomography...

Cerebral radiation necrosis (RN), a complication of Gamma Knife radiosurgery, is difficult to treat, although bevacizumab seems be effective. However, clinical data pertaining treatment for RN are scarce, and its high price problematic. This study explored the effectiveness low-dose caused by Knife. We retrospectively analyzed 22 patients who suffered cerebral post-Gamma Knife, received because poor efficacy glucocorticoids. Low-dose (3 mg/kg) was administered two cycles at 2-week intervals....

Lung adenocarcinoma (LUAD) is one of the most common cancers in world. Protein regulator cytokinesis 1 (PRC1) plays a role tumorigenesis and development several cancers, including LUAD. The aim present study to assess characteristics PRC1 LUAD order find potential drug that targets PRC1.We investigated prognostic value patients with using Cox analysis RNA sequencing data from Cancer Genome Atlas (TCGA) portal. A link between progression, cigarette smoking mutation count, aneuploidy, hypoxia...

A 33-year-old man had dizziness for 3 days without provoking factors. Head CT demonstrated a mass in the left lateral anterior cranial fossa with calcification and cystic degeneration (figure 1, A–C). MRI showed an irregularly shaped mixed signal slight marginal enhancement D–F). He underwent resection no recurrent during 12 months' follow-up. On pathologic examination, cyst inner lining consisted of ciliated pseudostratified columnar epithelium1,2 2). The diagnosis was bronchogenic cyst,...

Background: Diffuse midline glioma with a histone H3-K27M mutation is brand-new tumor entity according to the 2016 edition of World Health Organization (WHO) classification. As diffuse gliomas are aggressive and incurable brain tumors, characterized by high levels intrinsic acquired resistance therapy, as well conventional treatment can hardly work due an intact blood-brain barrier, leading very poor outcomes for patients. Anlotinib multitarget tyrosine kinase inhibitor has been used...