A5101480804- Cancer Immunotherapy and Biomarkers
- HER2/EGFR in Cancer Research
- Gynecological conditions and treatments
- Gastric Cancer Management and Outcomes
- Uterine Myomas and Treatments
- Lung Cancer Treatments and Mutations
- Prostate Cancer Treatment and Research
- Endometriosis Research and Treatment
- Cancer survivorship and care
- Cardiac Imaging and Diagnostics
- Cardiovascular Disease and Adiposity
- Monoclonal and Polyclonal Antibodies Research
- Intestinal and Peritoneal Adhesions
- Parkinson's Disease Mechanisms and Treatments
- Spine and Intervertebral Disc Pathology
- Breast Cancer Treatment Studies
- Advanced Breast Cancer Therapies
- Cardiac, Anesthesia and Surgical Outcomes
- Lung Cancer Research Studies
- Cancer Treatment and Pharmacology
- Gastrointestinal Tumor Research and Treatment
- Biomarkers in Disease Mechanisms
- Colorectal Cancer Treatments and Studies
- Vascular Tumors and Angiosarcomas
- Enhanced Recovery After Surgery
The Affiliated Yongchuan Hospital of Chongqing Medical University
2018-2025
Chongqing Medical University
2018-2025
Beijing Obstetrics and Gynecology Hospital
2017-2025
Capital Medical University
2017-2025
Beijing Tian Tan Hospital
2018-2025
Zhongshan Hospital
2019-2024
Fudan University
2019-2024
Second Affiliated Hospital of Harbin Medical University
2024
Binzhou University
2024
Binzhou Medical University
2024
Abstract Background The standard first‐line treatment for human epidermal growth factor receptor 2 (HER2)‐positive recurrent/metastatic breast cancer currently includes pertuzumab plus trastuzumab and docetaxel. This study aimed to evaluate the effectiveness of KN026, an anti‐HER2 bispecific antibody, docetaxel in HER2‐positive cancer. Methods open‐label, single‐arm, phase II enrolled patients with 19 centers across China from December 30, 2019 May 27, 2021. Patients were administered KN026...
// Qingguo Li 1, 3 , Lu Gan 2, Lei Liang Xinxiang Sanjun Cai 1 Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, People's Republic China 2 Medical Oncology, College, University, Correspondence to: Cai, e-mail: caisanjun_sh@163.com Li, lxx1149@163.com Keywords: cancer, marital status, SEER, survival analysis Received: December 15, 2014 Accepted: January 09, 2015 Published: February 06, ABSTRACT Marital status was found to be an independent prognostic factor...
The existence of gastric cancer stem cells (CSCs) has not been definitively proven and specific cell surface markers for identifying CSCs have largely identified. Our research aimed to isolate potential clarify their clinical significance, while defining GCSC identification verification. Here, we report that spheroid possess cell-like properties, overexpress certain markers. CD133 or CD44-positive also exhibit properties CSCs. expression Oct4, Sox2, Gli1, CD44, CD133, p-AKT, p-ERK was...
Objective . Adenomyosis is a common gynecologic benign disease that may have life-long negative impact on women. Previous studies indicated the endocannabinoid system participate in progress of endometriosis. Our research aims to analyze expression patterns typical cannabinoid receptors (CB1 and CB2), main constituents system, endometrial samples derived from patients diagnosed as adenomyosis or not. Methods Eutopic corresponding ectopic endometrium 45 premenopausal women normal 34...
Marital status was reported as a prognostic factor in many cancers. However, its role gastric cancer (GC) hasn't been thoroughly explored. In this study, we aimed to investigate the effect of marital on survival, stage, treatment, and survival subgroups.We used Surveillance, Epidemiology End Results (SEER) database identified 16910 GC patients. These patients were categorized into married (58.44%) unmarred (41.56%) groups. Pearson chi-square, Wilcoxon-Mann-Whitney, Log-rank, multivariate Cox...
A significant association between high blood-based tumor mutational burden (bTMB) and improved progression-free survival (PFS) was observed in advanced non-small cell lung cancer (NSCLC) receiving atezolizumab. However, this result unrepeatable a recent prospective study. We hypothesized that there might be non-linear bTMB survival. This study used the clinical genetic data from POPLAR (n = 105, training set) OAK 324, validation trials. The assessed using restricted cubic spline (RCS)....
One of the growing area interest in educational is student engagement which major construct positive psychology (PP) vital energetic, innovative, and pleasurable learning, but unluckily, all students are not engaged terms cognition, emotion, behavior learning. Another concept PP literature resilience emphasizes institutes' people's powers self-constraint to conform accidental conditions. Furthermore, mindfulness as a significant term has critical benefits such improving working memory,...
Background and Purpose— Cervicocerebral vascular calcification on computed tomography angiography is a known sign of advanced atherosclerosis. However, the clinical significance pattern remains unclear. In this study, we aimed to investigate potential association between spotty calcium acute ischemic stroke. Methods— This study included patients with first-time nonlacunar stroke (N=50) confirmed by brain magnetic resonance imaging or nonenhanced head tomography, as well control subjects...
Objective . To compare the effect of intrauterine suitable balloon (ISB) and Foley (FB) in prevention adhesion after hysteroscopic adhesiolysis patients with adhesions (IUAs). Methods A retrospective study was conducted on 150 women moderate severe IUAs, who underwent adhesiolysis. According to postoperative placement ISB or FB, cohort divided into group FB group. second-look hysteroscopy performed at 3 months postsurgery. The scoring system proposed by American Fertility Society (AFS) used...
Objective: To investigate the correlation between uterine volume and intrauterine adhesion (IUA). Methods: From June 2018 to November 2019, totally 7 007 patients who underwent hysteroscopy in outpatient operating rooms of Gynecological Minimally Invasive Center, Beijing Obstetrics Gynecology Hospital were retrospectively analyzed. Patients reproductive age with IUA without fibroids adenomyosis selected as group, during same period control group. The propensity score matching (PSM) method...
Abstract Background Freezing of gait (FOG) is a common disorder that often accompanies Parkinson's disease (PD). The current understanding brain functional organization in FOG was built on the assumption connectivity (FC) networks static, but FC changes dynamically over time. We aimed to characterize dynamic (DFC) patients with based high temporal‐resolution MRI (fMRI). Methods Eighty‐seven PD patients, including 29 and 58 without FOG, 32 healthy controls underwent resting‐state fMRI....
Shortening the duration of postoperative radiotherapy (RT) for breast cancer while maintaining efficacy and safety has become a significant trend. The 3-week regimen 40-42.5 Gy in 15-16 fractions is now preferred option clinical practice. Following publication 5-year outcomes from Fast-Forward trial, interest 1-week regimens surged, prompting initiation multiple studies. However, trials exploring regional nodal irradiation (RNI), especially involving internal mammary nodes (IMN), remain...
Abstract Objective We aimed to investigate the pharmacokinetics, safety, efficacy, and immunogenicity of different dosing regimens (weekly every three weeks) inetetamab in combination with vinorelbine human epidermal growth factor receptor 2 (HER2)+ patients metastatic breast cancer who had received one or more chemotherapy regimens. Methods HER2+ were included. Eligible administered weekly weeks injection chemotherapy. Pharmacokinetics, compared between groups. Results Sixty randomized into...
This study was designed to investigate the effect of neoadjuvant chemotherapy on expression hormone receptors and Ki67 in Chinese female breast cancer patients. The estrogen receptor (ER), progesterone (PR) among 525 cases studied by immunohistochemistry. Differences between specimens made through preoperative core needle biopsy excised tissue were observed. positive rates ER, PR 65.3% 63.2%, 51.0% 42.6%, 65.6% 43.4%, respectively. had no statistically significant difference. However, after...
Antipsychotic drugs are often prescribed to juvenile psychiatric patients, though their cerebral effects during development incompletely described. Accordingly, we studied the of repeated treatment with dissimilar antipsychotic on dopamine (DA) receptors in vs. adult rats. Tissue levels DA receptor types (D1, D2, D3, and D4) forebrain regions rats were quantified after 3 weeks daily representative first- (fluphenazine) second-generation (clozapine olanzapine) antipsychotics, compared...