A5100628384- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Lymphoma Diagnosis and Treatment
- MicroRNA in disease regulation
- Histone Deacetylase Inhibitors Research
- Hematopoietic Stem Cell Transplantation
- Retinoids in leukemia and cellular processes
- Neutropenia and Cancer Infections
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- COVID-19 Clinical Research Studies
- Epigenetics and DNA Methylation
- Lung Cancer Diagnosis and Treatment
- Immune cells in cancer
- Hematological disorders and diagnostics
- SARS-CoV-2 and COVID-19 Research
- Autophagy in Disease and Therapy
- COVID-19 and healthcare impacts
- Melanoma and MAPK Pathways
- Glioma Diagnosis and Treatment
Zhejiang Cancer Hospital
2021-2025
Zhejiang University
2013-2025
First Affiliated Hospital Zhejiang University
2013-2025
Nanjing Tech University
2025
Fuzhou Second Hospital
2025
Beckman Research Institute
2019-2024
Hangzhou Cancer Hospital
2022-2024
City of Hope
2017-2024
Blood Center of Zhejiang Province
2020-2023
Zhejiang Lab
2021-2022
Chronic lymphocytic leukemia (CLL) is the most prevalent subtype of in Western countries, causing a substantial health burden on patients and society. Comprehensive evaluation epidemiological characteristics CLL warranted, especially current context global population aging. The main objective this study evaluating disease at global, regional, national levels from 1990 to 2019. As secondary objectives, we studied influence demographic factors performed risk factor analysis. We hope could...
Abstract Current anticancer therapies cannot eliminate all cancer cells, which hijack normal arginine methylation as a means to promote their maintenance via unknown mechanisms. Here we show that targeting protein N -methyltransferase 9 (PRMT9), whose activities are elevated in blasts and leukemia stem cells (LSCs) from patients with acute myeloid (AML), eliminates disease cancer-intrinsic mechanisms cancer-extrinsic type I interferon (IFN)-associated immunity. PRMT9 ablation AML decreased...
Abstract The mechanisms underlying the transformation of chronic myeloid leukemia (CML) from phase (CP) to blast crisis (BC) are not fully elucidated. Here, we show lower levels miR-142 in CD34 + CD38 − blasts BC CML patients than those CP patients, suggesting that deficit is implicated evolution. Thus, create knockout (i.e., −/− BCR-ABL ) mice, which develop and die sooner wt +/+ instead remain CML. Leukemic stem cells (LSCs) mice recapitulate phenotype congenic recipients, supporting LSC...
Summary A chemotherapy‐based mobilization regimen in patients who mobilize poorly, based on etoposide, cytarabine and pegfilgrastim (EAP), has recently been introduced. The aim of this prospective study was to investigate the efficacy safety EAP with poorly mobilizing multiple myeloma (MM) or lymphoma. This single‐arm clinical trial performed at eight public hospitals China registered as a (NCT05510089). inclusion criteria were; (1) diagnosis MM lymphoma, (2) defined ‘poor mobilizer’ (3)...
This study aimed to evaluate the efficacy of metagenomic next-generation sequencing (mNGS) technology for identifying pathogens associated with spinal infection (SI). A retrospective analysis was conducted on clinical data from 193 patients suspected SI between August 2020 and September 2024. Based histopathological results, were divided into group (n=162) non-SI (n=31). The diagnostic performance mNGS compared that laboratory examination, imaging microbial culture. Among group, detected 135...
This paper evaluated the performance of two-dimensional (2D) and 3D texture features from CT images on pulmonary nodules diagnosis using large database LIDC-IDRI. Total 905 (422 malignant 483 benign) with certain expert observer ratings malignancy were extracted based radiologists' painting boundaries. Feature analysis was not only popular method, e.g., 2D Haralick feature model, we also explored a model variable directions in space. The relationships more neighbour voxels included for...
Transient receptor potential vanilloid 4 (TRPV4) has been reported to be involved in the progression of several human tumors. Nevertheless, clinical significance and molecular mechanism TRPV4 gastric cancer (GC) remain poorly defined.Immunohistochemistry assays were used investigate correlation between expression epithelial-mesenchymal transition (EMT) markers GC tissues. The correlations clinicopathological features survival rates also examined. knockdown was performed by using small...
During acute myeloid leukemia (AML) growth, the bone marrow (BM) niche acquires significant vascular changes that can be offset by therapeutic blast cytoreduction. The molecular mechanisms of this plasticity remain to fully elucidated. Herein, we report on occur in compartment FLT3-ITD+ AML BM pre and post treatment their impact leukemic stem cells (LSCs). vasculature was evaluated models (MllPTD/WT/Flt3ITD/ITD mouse patient-derived xenograft) 3D confocal imaging long bones, calvarium...
// Xia Li 1, 2, * , Xiufeng Yin Huafeng Wang 2 Jiansong Huang Mengxia Yu Zhixin Ma Chenying Yile Zhou Xiao Yan ShuJuan Jie Jin 3 1 Department of Hematology, The First Affiliated Hospital Zhejiang University, Hangzhou, People's Republic China Institute University School Medicine, Key Lab Hematopoietic Malignancy, Zhejiang, These authors contributed equally to this work and share first authorship Correspondence to: Jin, email: zjuhematology@163.com Keywords: acute myeloid leukemia, FLT3-ITD,...