A5103265844- Acute Myeloid Leukemia Research
- RNA modifications and cancer
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Epigenetics and DNA Methylation
- Childhood Cancer Survivors' Quality of Life
- Protein Degradation and Inhibitors
- Lymphoma Diagnosis and Treatment
- PARP inhibition in cancer therapy
- Histone Deacetylase Inhibitors Research
- Cancer-related gene regulation
- DNA Repair Mechanisms
- Integrated Circuits and Semiconductor Failure Analysis
- Electrohydrodynamics and Fluid Dynamics
- Cancer, Hypoxia, and Metabolism
- Plasma Diagnostics and Applications
- Microbial Fuel Cells and Bioremediation
- Dietary Effects on Health
- Traditional Chinese Medicine Studies
- RNA Research and Splicing
- Advanced Photocatalysis Techniques
- Legume Nitrogen Fixing Symbiosis
- Kruppel-like factors research
- Muon and positron interactions and applications
Beijing Institute of Technology
2017-2024
Zhejiang University
2017-2024
First Affiliated Hospital Zhejiang University
2014-2024
Ministry of Agriculture and Rural Affairs
2024
Hangzhou Cancer Hospital
2024
Guangdong Medical College
2024
Agricultural Genomics Institute at Shenzhen
2024
Chinese Academy of Agricultural Sciences
2022-2024
Qingdao Agricultural University
2024
City of Hope
2019-2023
The cancer burden in adolescents and young adults (AYAs) deserves more attention. However, global statistics for AYAs are often presented as aggregates, concealing important heterogeneity. This study aimed to describe the worldwide profile of incidence, mortality, corresponding trends from 1990 2019 among 15-39-year olds by focusing on patterns age, sex, sociodemographic index (SDI), regions.Global, regional, country data number cases cancer-related deaths 29 types were collected Global...
PARP-1 plays a critical role in DNA damage repair and contributes to progression of cancer. To explore the acute myeloid leukemia (AML), we analyzed expression AML its relation clinical prognosis. Then, investigated efficacy mechanism PARP inhibitor BMN673 (Talazoparib) combined with NL101, novel SAHA-bendamustine hybrid vitro vivo.The 339 cytogenetically normal (CN-AML) cases was evaluated using RT-PCR. According PARP-1, characteristics prognosis patients were grouped compared. The...
Abstract Background Spermatogenesis associated serine rich 2 like (SPATS2L) was highly expressed in homoharringtonine (HHT) resistant acute myeloid leukemia (AML) cell lines. However, its role is little known AML. The present study aimed to investigate the function of SPATS2L AML pathogenesis and elucidate underlying molecular mechanisms. Methods Overall survival (OS), event-free (EFS), relapse-free (RFS) were used evaluate prognostic impact for from TCGA database ourcohort. ShRNA knockdown...
The identification of genetic risk subgroups T-cell acute lymphoblastic leukemia (T-ALL) may provide evidence for stratification and individualized treatment. We investigated the characteristics prognostic value tumor suppressor gene CDKN2A deletions in 101 patients with T-ALL. deletion was present 23% (23/101) T-ALL by fluorescence situ hybridization (FISH). most common type homozygous (70%, 16/23). A lower frequency found early precursor (ETP) ALL than non-ETP-ALL (10.4% vs 34.0%; P =...
Summary Glutamine metabolic reprogramming in acute myeloid leukaemia (AML) cells contributes to the decreased sensitivity antileukemic drugs. Leukaemic cells, but not their counterparts, largely depend on glutamine. Glutamate dehydrogenase 1 (GDH1) is a regulation enzyme glutaminolysis. However, its role AML remains unknown. Here, we reported that GDH1 was highly expressed AML: high one of independent negative prognostic factors cohort. The dependence leukaemic proved both vitro and vivo....
Background: Adult T-cell acute lymphoblastic leukemia (T-ALL) is a rare hematological malignancy, and significantly linked to poor outcomes. Early precursor (ETP) unique subtype of T-ALL. The aim this study compare the differences between ETP non-ETP ALLs in China. Methods: We retrospectively analyzed records 122 adult T-ALL patients diagnosed treated at our center Jan 2014 Jun 2019. All enrolled were categorized into ALL by immunophenotype, further statistical analysis about clinical data...
Abstract Glandular trichomes of tobacco (Nicotiana tabacum) produce blends acylsucroses that contribute to defence against pathogens and herbivorous insects, but the mechanism assembly these acylsugars has not yet been determined. In this study, we isolated characterized two trichome-specific acylsugar acyltransferases are localized in endoplasmic reticulum, NtASAT1 NtASAT2. They sequentially catalyse additive steps acyl donors sucrose di-acylsucrose. Knocking out or NtASAT2 resulted...
// Xia Li 1, 2, * , Xiufeng Yin Huafeng Wang 2 Jiansong Huang Mengxia Yu Zhixin Ma Chenying Yile Zhou Xiao Yan ShuJuan Jie Jin 3 1 Department of Hematology, The First Affiliated Hospital Zhejiang University, Hangzhou, People's Republic China Institute University School Medicine, Key Lab Hematopoietic Malignancy, Zhejiang, These authors contributed equally to this work and share first authorship Correspondence to: Jin, email: zjuhematology@163.com Keywords: acute myeloid leukemia, FLT3-ITD,...
Circular RNAs (circRNAs), a type of endogenous noncoding RNA (ncRNA), exert vital roles in leukemia progression and are promising prognostic factors. Here, we report novel circRNA, circSLC25A13 (hsa_circ_0081188), which was increased acute myeloid (AML) patients with poor overall survival (OS) comparing to good prognosis. Knockdown AML cells inhibited proliferation cell apoptosis vitro vivo. Enhanced expression promoted the cells. Mechanistically, played as microRNA sponge miR-616-3p,...
Angioimmunoblastic T-cell lymphoma (AITL) is a major subtype of peripheral (PTCL). Due to its low incidence, the characteristics AITL are still not well understood. The prognostic evaluation this disease has been established.We retrospectively analyzed 52 patients with newly diagnosed in China between January 2008 and September 2016.Among these patients, median age at diagnosis was 62 (40-83) 58% (30/52) were older than 60 years. Thirty-five male, accounting for 67.3% whole. Among these, 90%...
Summary Minimal residual disease (MRD) is an important independent prognostic factor for relapse and survival in acute lymphoblastic leukaemia (ALL). Compared with adult B‐cell ALL, reports of T‐cell ALL (T‐ALL) MRD have been scarce mostly based on molecular methods. We evaluated the value multiparameter flow cytometry (FCM)‐based at end induction (EOI‐MRD). The present retrospective study included 94 patients T‐ALL. was detected by six‐ to eight‐colour FCM. Patients who were EOI‐MRD...
Probiotics are considered to exert beneficial effects in humans and animals by modulating the structure metabolic functions of gut microbiota. Therefore, identification functional probiotics in-depth exploration characteristics applicability paramount significance for development more effective probiotic products formulation personalized treatment strategies fields human health livestock farming. However, due current limitations sequencing technologies considering that microbial communities...