A5080357932- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Acute Myeloid Leukemia Research
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Acute Lymphoblastic Leukemia research
- BRCA gene mutations in cancer
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Nuts composition and effects
- Cancer, Lipids, and Metabolism
- Metabolism, Diabetes, and Cancer
- Bacteriophages and microbial interactions
- Ovarian cancer diagnosis and treatment
- Helicobacter pylori-related gastroenterology studies
- DNA Repair Mechanisms
- Chemical Synthesis and Analysis
- Childhood Cancer Survivors' Quality of Life
- Oral Health Pathology and Treatment
- Antimicrobial Peptides and Activities
- Histone Deacetylase Inhibitors Research
- Chronic Lymphocytic Leukemia Research
- Adipokines, Inflammation, and Metabolic Diseases
- Protein Hydrolysis and Bioactive Peptides
Beckman Research Institute
2022-2025
City of Hope
2022-2025
Jean Mayer Human Nutrition Research Center on Aging
2018
Tufts University
2014-2018
Tufts Medical Center
2013-2014
National Yang Ming Chiao Tung University
2007
Taipei Veterans General Hospital
2007
Abstract Background While liver cancer stem cells (CSCs) play a crucial role in hepatocellular carcinoma (HCC) initiation, progression, recurrence, and treatment resistance, the mechanism underlying CSC self-renewal remains elusive. We aim to characterize of Methyltransferase 16 (METTL16), recently identified RNA N 6 -methyladenosine (m A) methyltransferase, HCC development/maintenance, stemness, as well normal hepatogenesis. Methods Liver-specific Mettl16 conditional KO (cKO) mice were...
RNA N 6 -methyladenosine (m A) modification and its regulators fine tune gene expression contribute to tumorigenesis.This study aims uncover the essential role underlying molecular mechanism(s) of m A reader YTHDC1 in promoting triple negative breast cancer (TNBC) metastasis.Methods: In vitro vivo models were employed determine pathological function TNBC metastasis.To identify bona fide target RNAs, we conducted RNA-seq, A-seq, RIP-seq, followed by integrative data analysis validation...
Abstract Natural killer (NK) cell-based immunotherapy is emerging to be a promising strategy treat cancers due its high safety profile. Compared with traditional chimeric antigen receptor (CAR) T therapy, NK therapy has much lower side effects such as cytokine release syndrome (CRS) or neurotoxicity. However, the limited persistence and levels of infiltration tumor microenvironment impeded outcomes for clinical trials. How genetically engineer cells better priming activation state yet...
Current immunotherapies have shown limited success in treating acute myeloid leukemia (AML) due to immune evasion, which often stems from epigenetic dysregulation of immune-related pathways. TET2, a well-studied DNA 5-methylcytosine dioxygenase, is frequently mutated and recognized as tumor suppressor AML. While TET2 deficiency hematopoietic stem/progenitor cells (HSPCs) has been associated with elevated inflammation, also reported promote inflammatory interferon (IFN) signaling solid...
Although the overall survival rate of B cell acute lymphoblastic leukemia (B-ALL) in childhood is more than 80%, it merely 30% refractory/relapsed and adult patients with B-ALL. This demonstrates a need for improved therapy targeting this subgroup Here, we show that ten-eleven translocation 1 (TET1) protein, dioxygenase involved DNA demethylation, overexpressed plays crucial oncogenic role independent its catalytic activity Consistent B-ALL, overexpression TET1 alone normal precursor cells...
Highlights•Metformin substantially sensitizes FLT3-mutated AML cells to gilteritinib in vitro•Metformin synergizes with treating FLT3-ITD vivo•Metformin and cooperatively target PLK1/STAT5-ERK-mTOR AML•Metformin plus TKI offers a potent cost-effective therapy for AMLSummaryFms-like tyrosine kinase 3 (FLT3) mutations, present over 30% of acute myeloid leukemia (AML) cases dominated by FLT3-internal tandem duplication (FLT3-ITD), are associated poor outcomes patients AML. While inhibitors...
Patients with BRCA-1 and BRCA-2 germ line mutations are at an increased risk of developing pancreatic adenocarcinoma (PAC). In particular, the mutation has been associated a relative PAC 3.51. The protein is involved in repair double-stranded DNA breaks. Recent reports have suggested that setting impaired repair, chemotherapeutic agents induce damage, such as platinum-based antineoplastic drugs (platins) poly(ADP-ribose) polymerase inhibitors (PARP inhibitors), improved efficacy. However,...
Obesity, a risk factor for colorectal cancer, raises systemic levels of proinflammatory mediators. Whether increased also reside in the colons obese individuals and are accompanied by procancerous alterations mucosal transcriptome is unknown.Concentrations TNFα, IL1β, IL6 blood colonic mucosa 16 lean 26 were examined. Differences between two groups defined.Plasma TNFα 1.4- to 3-fold elevated subjects [body mass index (BMI) ≥ 34 kg/m2] compared with controls (P < 0.01). Among BMI kg/m2...
Abstract Background: As the most prevalent internal decorations in mammalian mRNA, N6-methyladenosine (m6A) has been reported to be involved many physiological and pathological processes, including acute myeloid leukemia (AML). METTL3 METTL14, well-recognized m6A methyltransferase complex, contribute AML. METTL16 is a recently identified that deposit few targets. While, unlike METTL3/14, biological functions of are largely unknown. Here, we explored function mechanism AML pathogenesis...
Objective‐ Obesity elevates the risk of colon cancer; however, molecular mechanisms responsible for this association remain speculative. Our lab has previously demonstrated that murine obesity colonic TNFα and IL‐1β, each which is known to activate important pro‐carcinogenic signaling pathways. We hypothesized low‐grade inflammatory state associated with also exists in human. Methods‐ Whole blood biopsies were collected from obese (BMI 蠅 30) lean 蠄 25) human subjects undergoing routine...
Abstract Introduction: Albeit that over 170 types of chemical modifications have been identified in RNAs, the biological functions most those decorations are still elusive. N7-methylguanosine (m7G), routinely occurring at 5’ cap mRNA or within tRNA and rRNA, also exists internal mRNA. However, “reader” proteins recognize m7G regulate metabolism fate target mRNAs yet to be identified. Here, we aim identify reader(s) elucidate function. Methods: To reader(s), utilized RNA-pull down, mass...