Xiaolan Deng
A5090163888- RNA modifications and cancer
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Analytical Chemistry and Chromatography
- RNA and protein synthesis mechanisms
- Acute Myeloid Leukemia Research
- Kruppel-like factors research
- Microfluidic and Capillary Electrophoresis Applications
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Antibiotics Pharmacokinetics and Efficacy
- CAR-T cell therapy research
- Medicinal plant effects and applications
- Aldose Reductase and Taurine
- Histone Deacetylase Inhibitors Research
- Lung Cancer Treatments and Mutations
- PI3K/AKT/mTOR signaling in cancer
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- Biochemical and Molecular Research
- Dysphagia Assessment and Management
- Vitamin D Research Studies
- Traditional Chinese Medicine Studies
Beckman Research Institute
2017-2025
City of Hope
2017-2025
Sanya University
2008-2024
Haikou City People's Hospital
2024
Hainan University
2008-2023
Central South University
2011-2023
Nanjing Drum Tower Hospital
2016-2021
China Medical University
2014-2019
University of Cincinnati
2017-2019
University of Cincinnati Medical Center
2017-2018
Abstract Background While liver cancer stem cells (CSCs) play a crucial role in hepatocellular carcinoma (HCC) initiation, progression, recurrence, and treatment resistance, the mechanism underlying CSC self-renewal remains elusive. We aim to characterize of Methyltransferase 16 (METTL16), recently identified RNA N 6 -methyladenosine (m A) methyltransferase, HCC development/maintenance, stemness, as well normal hepatogenesis. Methods Liver-specific Mettl16 conditional KO (cKO) mice were...
RNA N 6 -methyladenosine (m A) modification and its regulators fine tune gene expression contribute to tumorigenesis.This study aims uncover the essential role underlying molecular mechanism(s) of m A reader YTHDC1 in promoting triple negative breast cancer (TNBC) metastasis.Methods: In vitro vivo models were employed determine pathological function TNBC metastasis.To identify bona fide target RNAs, we conducted RNA-seq, A-seq, RIP-seq, followed by integrative data analysis validation...
Over 170 chemical modifications have been identified in protein-coding and noncoding RNAs shown to exhibit broad impacts on gene expression. Dysregulation of RNA caused by aberrant expression or mutations modifiers aberrantly reprograms the epitranscriptome skews global expression, which turn leads tumorigenesis drug resistance. Here we review current knowledge functions underlying mechanisms human cancers, particularly several common modifications, including N 6 -methyladenosine (m A),...
Homoharringtonine, a plant alkaloid, has been reported to suppress protein synthesis and approved by the US Food Drug Administration for treatment of chronic myeloid leukemia. Here we show that in acute leukemia (AML), homoharringtonine potently inhibits cell growth/viability induces cycle arrest apoptosis, significantly disease progression vivo, substantially prolongs survival mice bearing murine or human AML. Strikingly, dramatically decreases global DNA 5-hydroxymethylcytosine abundance...
Objective: Deregulation of long noncoding RNAs (lncRNAs) is involved in the initiation and progression cancer. LncRNA DLX6-AS1 regarded as an oncogene many cancer types. However, clinical role serum exosomal lncRNA cervical (CC) poorly known. This study aimed to analyze diagnostic prognostic value CC. Methods: A total 114 patients with CC, 60 CIN (cervical intraepithelial neoplasia), 110 healthy women were enrolled this study. Real-time quantitative reverse transcription-polymerase chain...