A5043260254- Angiogenesis and VEGF in Cancer
- Asthma and respiratory diseases
- Cancer-related molecular mechanisms research
- Connexins and lens biology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Receptor Mechanisms and Signaling
- Peripheral Neuropathies and Disorders
- Myasthenia Gravis and Thymoma
- Cell Adhesion Molecules Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- MicroRNA in disease regulation
- Atherosclerosis and Cardiovascular Diseases
- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- Glycosylation and Glycoproteins Research
- Calpain Protease Function and Regulation
- Circular RNAs in diseases
- Advanced Glycation End Products research
- Bacteriophages and microbial interactions
- PI3K/AKT/mTOR signaling in cancer
- Neonatal and fetal brain pathology
- Sphingolipid Metabolism and Signaling
- Morinda citrifolia extract uses
- Advanced Drug Delivery Systems
- Sirtuins and Resveratrol in Medicine
Qingdao University of Science and Technology
2024
Shandong University of Traditional Chinese Medicine
2023
Rutgers, The State University of New Jersey
2019-2022
Chinese PLA General Hospital
2020-2022
Sir Run Run Shaw Hospital
2008-2021
Zhejiang University
2008-2021
Affiliated Hospital of Guizhou Medical University
2021
Guiyang Medical University
2021
Environmental and Occupational Health Sciences Institute
2020
Chinese People's Liberation Army
2020
Rapamycin suppresses endothelial proliferation and migration, which leads to delayed re-endothelialization in the rapamycin-eluted stents that are used coronary heart disease patients. Because microRNAs (miRs) play important roles angiogenesis, we tested hypothesis rapamycin induces suppression, partly through pathways involve miRs. treatment increased expression of miR-21 HUVECs. The downregulation by inhibitors abolished negative effects on cell growth mobility. RhoB was confirmed as a...
The aim of the present study was to design a depot delivery system ropivacaine hydrochloride using multivesicular liposomes (RP-MVLs) overcome limitations conventional therapies and investigate it's in vivo effectiveness for sustained delivery. RP-MVLs were prepared by multiple emulsion method. Appearance, particle size, encapsulation efficiency, zeta potential, initial stability RP-MVL also studied. vitro release formulations found be manner. Three batches profile fitted first-order...
Stroke is associated with high morbidity and mortality, much remains unknown about the injury-related mechanisms that occur following reperfusion. This study aimed to explore roles of Toll-like receptor 2 (TLR2) sphingosine kinase 1 (Sphk1) in microglial cells inflammatory responses induced by cerebral ischemia/reperfusion (I/R). For this purpose, C57BL/6 mice were randomly divided into 4 groups as follows: sham-operated group, I/R group treated TLR2 antibody, N,N-dimethylsphingosine. Focal...
Abstract Thymosin β4 (Tβ4) has been suggested to regulate multiple cell signal pathways and a variety of cellular functions such as migration, proliferation, survival, angiogenesis. Here, we investigated the effect Tβ4 on endothelial progenitor cells (EPCs) apoptosis induced by serum deprivation corresponding transduction involved in this process. Circulating EPCs, isolated from healthy volunteers, were cultured absence or presence various cascade inhibitors. Apoptosis was evaluated with...
The remodeling of cardiac gap junction contributes to the arrhythmias in a diabetic heart. We previously reported that high glucose reduced Cx43 protein level neonatal rat cardiomyocytes. But, effect and mechanisms advanced glycation end product (AGE) on expression still remain unclear. In this study, we measured AGE receptor (RAGE) by immunohistochemisty AGE-infused Sprague-Dawley (SD) rats. vitro, RAGE levels were detected AGE-treated cardiomyocytes Western blot real-time RT-PCR. function...
The remodeling of cardiac gap junctions contributes to various arrhythmias in a diabetic heart. We previously reported that Epigallocatechin-3-gallate (EGCG) attenuated connexin43 (Cx43) protein downregulation induced by high glucose (HG) neonatal rat cardiomyocytes, but Cx43 mRNA expression was not affected. It indicated the possible mechanisms post-transcriptional regulation, which still remains unclear. As microRNAs (miRNAs) regulate gene widely at level, we measured miR-1/206...
Obesity can aggravate asthma by enhancing airway hyperresponsiveness (AHR) and attenuating response to treatment. However, the precise mechanisms linking obesity remain unknown. Human smooth muscle (HASM) cells exhibit amplified excitation-contraction (EC) coupling force generation in obesity. Therefore, we posit that (ASM) obtained from obese donors manifest a metabolomic phenotype distinct of nonobese donor differential metabolic phenotype, at least part, drives enhanced ASM cell EC...
Aims: The remodeling of cardiac gap junctions has been postulated to contribute the arrhythmias in a diabetic heart. Epigallocatechin-3 gallate (EGCG), green tea catechin, recently recognized for its protection cardiovascular disease. This study investigated effect EGCG on possible under high glucose cultured neonatal rat cardiomyocytes. Methods: Cardiomyocytes pre-incubated with (30mM) were co-treated by EGCG. expression Connexin43 (Cx43), Cx40 and Cx45 determined Western blot real-time...
Objective This study aimed to summarize the clinical characteristics and prognosis of patients with anti- acetylcholine receptor (AChR) positive myasthenia gravis (MG) a combination anti-LRP4 or Titin antibodies. Methods A total 188 generalized MG before immunotherapy were retrospectively collected then divided into three groups: single anti-AChR positive-MG (AChR-MG, 101 cases), combined anti-low-density lipoprotein receptor-related protein four-positive (AChR+LRP4-MG, 29...
Background: Epigallocatechin gallate (EGCG) is the most abundant catechin in green tea and has proven benefits on endothelial cells diabetes. However, it remains unclear whether EGCG could improve function of late progenitor (L-EPCs) Methods: Thirty-six rabbits were randomized into six groups. Thirty diabetic induced by a single dose alloxan (100 mg/kg injection intraperitoneally). All them given intragastrically (50 mg/kg/day) or saline for 7 days after carotid injury. In autotransfusion...
Bronchomotor tone modulated by airway smooth muscle shortening represents a key mechanism that increases resistance in asthma. Altered glucose metabolism inflammatory and structural cells is associated with Although these observations suggest causal link between hyperresponsiveness, the mechanisms are unclear. We hypothesized glycolysis modulates excitation-contraction coupling human (HASM) cells. Cultured HASM from lung donors were subject to metabolic screenings using Seahorse XF cell...