A5056124982- Virus-based gene therapy research
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Antibiotic Resistance in Bacteria
- Genomics, phytochemicals, and oxidative stress
- RNA modifications and cancer
- Salmonella and Campylobacter epidemiology
- Escherichia coli research studies
- Viral Infections and Immunology Research
- Signaling Pathways in Disease
- CRISPR and Genetic Engineering
- Genomics and Phylogenetic Studies
- Extracellular vesicles in disease
- Renal and related cancers
- Microbial infections and disease research
- Animal Nutrition and Physiology
- Ion channel regulation and function
- Circular RNAs in diseases
- RNA Research and Splicing
- Genetic and Kidney Cyst Diseases
- Aquaculture disease management and microbiota
- Gut microbiota and health
- Telomeres, Telomerase, and Senescence
Anhui Academy of Agricultural Sciences
2016-2025
Jiaxing University
2017-2025
Animal Science Research Institute
2016-2024
Nanjing Agricultural University
2012-2024
Poultry Research Institute
2022-2023
Sir Run Run Shaw Hospital
2011-2022
Zhejiang University
2011-2022
Jiangxi Provincial Cancer Hospital
2020-2022
King Center
2020
Tsinghua University
2020
Abstract Plastoquinone and tocopherols are the two major quinone compounds in higher plant chloroplasts synthesized by a common pathway. In previous studies we characterized loci Arabidopsis defining key steps of this biosynthetic Mutation PDS1 locus disrupts activity p-hydroxyphenylpyruvate dioxygenase (HPPDase), first committed step synthesis both plastoquinone plants. Although plants homozygous for pds1 mutation could be rescued growth presence homogentisic acid, product HPPDase, were...
<b><i>Background/Aims: </i></b>Diabetes mellitus (DM) can lead to renal damage and dysfunction, exacerbate ischemia/reperfusion injury (RI/RI). The aim of this study was investigate the protective effect GSK-3β inhibitor TDZD-8 against RI/RI through Nrf2/TrxR2 signaling pathway in a rat DM model. <b><i>Methods:</i></b> A model established by single injection streptozocin. Diabetic rats were pretreated with (1 mg/kg bw) or TDZD-8+auranofin (10...
Salmonella is one of the most important zoonotic pathogens that can cause both acute and chronic illnesses in poultry flocks, also be transmitted to humans from infected poultry. The purpose this study was investigate prevalence, antimicrobial resistance, molecular characteristics isolated diseased clinically healthy chickens Anhui, China. In total, 108 isolates (5.66%) were successfully recovered chicken samples (n = 1908), including pathological tissue (57/408, 13.97%) cloacal swabs...
Lead is a persistent inorganic environmental pollutant with global implication for human health. Among the diseases associated lead exposure, damage to central nervous system has received considerable attention. It been reported that long-term exposure increases risk of meningioma; however, underlying mechanism remains poorly understood. Clinical studies have indicated loss-of-function and mutations in neurofibromin-2 (NF2) gene play crucial role promoting meningioma formation. The effect Pb...
Diabetes mellitus can exacerbate renal ischemia-reperfusion (I/R) injury (RI/RI). The aim of the present study was to evaluate protective effect GSK-3β inhibition (TDZD-8) on I/R-induced through Nrf2/HO-1 pathway in a streptozocin (STZ)-induced diabetic rat model.STZ-induced rats preconditioned with TDZD-8 and ZnPP were subjected I/R. extent morphologic lesions. Renal function assessed from blood urea nitrogen (BUN) serum creatinine (Scr), as determined utlizing commercial kits. Oxidative...
Coriolus versicolor (C. versicolor) is a higher fungi or mushroom which now known by its accepted scientific names as Trametes (L.) Lloyd. Many studies have shown that β-glucans from C. various physiological activities, including activating macrophages to protect against Salmonella infection. However, whether antiviral effects has not been reported. Hence, the objective of this study was confirm could boost immune response combat influenza virus in mouse and chick models. The results show...
First identified as a new circovirus in Hunan Province China 2019, porcine (PCV4) is now widely detected other Chinese provinces and South Korea. In recent years, the virus has threatened pig health operations industry. Hence, early PCV4 detection regular surveillance are required to control spread of infection prevent collateral damage Due being difficult isolate vitro, molecular methods, such conventional PCR real-time PCR, serological assays currently main methods used for infection....
Duck tembusu virus (DTMUV), which causes huge economic losses for the poultry industries in Southeast Asia and China, was first identified 2010. DTMUV disease has become an important that endangers duck industry. A sensitive, accurate, convenient detection method is means to reduce occurrence of disease. In this study, a CRISPR/Cas13a system combined with recombinase polymerase amplification develop diagnostic detect DTMUV. The novel based on isothermal at 37°C, used visual readout or...
Pullorum disease caused by Salmonella pullorum is one of the most important infectious diseases in poultry industry, responsible for causing substantial economic losses globally. On farms, traditional method to detect S. infection mainly involves collection feces and sera test antigens antibodies, respectively, but regularity dissemination internal organs shedding patterns antibody production infected chickens remains unclear. Herein we aimed investigate different bacterial faeces as well...
The high mortality rate of weaned piglets infected with porcine epidemic diarrhea virus (PEDV) poses a serious threat to the pig industry worldwide, demanding urgent research efforts related developing effective antiviral drugs prevent and treat PEDV infection. Small molecules can possibly spread infection by targeting specific vital components pathogen's genome. Main protease (Mpro, also named 3CL protease) plays essential roles in replication has emerged as promising target for inhibition...
Porcine epidemic diarrhea virus (PEDV) mainly causes acute and severe porcine (PED), is highly fatal in neonatal piglets. No reliable therapeutics against the infection exist, which poses a major global health issue for Luteolin flavonoid with anti-viral activity toward several viruses.
The widespread occurrence of fowl adenovirus serotype 4 (FAdV-4)-induced hepatitis-hydropericardium syndrome (HHS) has led to significant economic losses for the poultry industry. A sensitive, accurate, and practical FAdV-4 diagnostic approach is urgently required limit incidence disease. In present study, a method detecting was developed using CRISPR/Cas13a system recombinase-aided amplification. based on 37°C isothermal detection with visible results being achieved. target gene this only...
ABSTRACT. Polycystin-L (PCL), the third member of polycystin family proteins, functions as a Ca2+-modulated nonselective cation channel when expressed in Xenopus oocytes. Polycystin-1 and -2 are mutated autosomal-dominant polycystic kidney disease (ADPKD), but role PCL has not been determined. In this study, an anti-peptide polyclonal antiserum was generated against carboxyl terminal domain human used to determine patterns expression distribution by indirect immunofluorescence both...
Numerous circular RNAs (circRNAs) are functionally investigated in various human cancers, including colorectal cancer (CRC). In this study, we explored the function of circCSNK1G1 and mechanism action CRC, aiming to provide evidence for involving CRC pathogenesis.The expression circCSNK1G1, miR-455-3p Myosin VI (MYO6) were examined using quantitative real-time polymerase chain reaction (qRT-PCR). The functions on cell proliferation, apoptosis, cycle migration/invasion 3-(4,...
Although coronary artery bypass graft (CABG) surgery is the main method to revascularize occluded vessels in diseases, full benefits of operation are mitigated by ischemia-reperfusion (IR) injury. many studies have been devoted reducing IR injury animal models, translation this research into clinical field has disappointing. Our study aimed explore underlying hub genes and mechanisms injury.A weighted gene co-expression network analysis (WGCNA) was executed based on expression profiles...