A5007732950- Air Quality and Health Impacts
- Heavy Metal Exposure and Toxicity
- Toxic Organic Pollutants Impact
- Climate Change and Health Impacts
- Pain Mechanisms and Treatments
- Recycling and Waste Management Techniques
- Inflammasome and immune disorders
- Noise Effects and Management
- Air Quality Monitoring and Forecasting
- Bone Metabolism and Diseases
- Pharmacological Effects of Natural Compounds
- Microplastics and Plastic Pollution
- Cytokine Signaling Pathways and Interactions
- Neuroinflammation and Neurodegeneration Mechanisms
- Microbial Inactivation Methods
- Orthopedic Surgery and Rehabilitation
- Pulmonary Hypertension Research and Treatments
- Cardiac Arrest and Resuscitation
- Adipokines, Inflammation, and Metabolic Diseases
- Bone fractures and treatments
- Elbow and Forearm Trauma Treatment
- Biomarkers in Disease Mechanisms
- Heme Oxygenase-1 and Carbon Monoxide
- Traumatic Brain Injury and Neurovascular Disturbances
- Thermoregulation and physiological responses
Jiaxing University
2018-2025
Institute of Forensic Science
2021-2023
Nanjing Medical University
2014-2023
Xuzhou Medical College
2021-2023
Xuzhou Central Hospital
2021-2023
Nanjing University of Chinese Medicine
2021-2023
Southeast University
2022
Jilin University
2022
Bridge University
2021
Changhai Hospital
2021
Lead is a persistent inorganic environmental pollutant with global implication for human health. Among the diseases associated lead exposure, damage to central nervous system has received considerable attention. It been reported that long-term exposure increases risk of meningioma; however, underlying mechanism remains poorly understood. Clinical studies have indicated loss-of-function and mutations in neurofibromin-2 (NF2) gene play crucial role promoting meningioma formation. The effect Pb...
Background/Aims: Paeoniflorin (PF) is known to have anti-inflammatory and paregoric effects, but the mechanism underlying its analgesic effect remains unclear. The aim of this study was clarify PF on Freund’s complete adjuvant (CFA)-induced inflammatory pain explore molecular mechanism. Methods: An model established by intraplantar injection CFA in C57BL/6J mice. After intrathecal daily for 8 consecutive days, thermal mechanical withdrawal thresholds, levels factors TNF-α, IL-1β IL-6,...
Chemokine, monocyte chemoattractant protein-1 (MCP-1), is a potential factor to cause cancer-induced bone pain (CIBP). NF-κB signaling very important in mediating the expression of chemokines and may have role CIBP. However, mechanism still unclear. This study investigates CIBP by regulating MCP-1/chemokine CC motif receptor-2 (CCR2) pathway.A rat model was established injecting Walker-256 cells into tibia medullary cavity. Nine days later, animals were intrathecally administrated with MCP-1...
Abstract Background The development of antinociceptive tolerance following repetitive administration opioid analgesics significantly hinders their clinical use. Evidence has accumulated indicating that microglia within the spinal cord play a critical role in morphine tolerance. present study investigated effects and possible mechanisms natural compound, paeoniflorin, via its specific inhibition microglial activation. Methods cell line BV ‐2 was used. C ytokine expression measured using...
Abstract Background Senile osteoporosis can cause bone fragility and increased risk for fractures has been one of the most prevalent severe diseases affecting elderly population worldwidely. The underlying mechanisms are currently intensive areas investigation. In age-related loss, decreased formation overweighs resorption. molecular defective in loss not completely understood. particular, specific role histone acetylation examined thoroughly. Methods We employed 6- 18-month-old mice to...
Tetrabromodiphenyl ether (BDE-47) is widely used as commercial flame retardants that can be released into the environment and finally enter human body through food chain. It has been identified to generate neurotoxicity, but little known about auditory damage underlying mechanism following BDE-47 exposure. This study aimed assess cell viability with concentration ranging from 0 150 μM in mouse organ of Corti-derived lines (HEI-OC1). Aryl hydrocarbon receptor (AhR) an environmental sensor,...
Environmental pollution often releases multiple contaminants resulting in as yet largely uncharacterized additive toxicities. Cadmium (Cd) is a widespread pollutant that induces nephrotoxicity animal models and humans. However, the combined effect of Cd causing with 2,2',4,4'-tetrabromodiphenyl ether (BDE-47), typical congener polybrominated diphenyl ethers (PBDEs), has not been evaluated mechanisms are completely clear. Here, we applied transcriptome sequencing analysis to investigate...
Descending nociceptive modulation from the supraspinal structures has an important role in cancer-induced bone pain (CIBP). Midbrain ventrolateral periaqueductal gray (vlPAG) is a critical component of descending circuits; nevertheless, its precise cellular and molecular mechanisms involved facilitation remain elusive. Our previous study shown that activation p38 MAPK vlPAG microglia essential for neuropathic sensitization. However, existence potential connection between astrocytes c-Jun...
The central physiological role of the bone marrow renders stromal cells (BMSCs) particularly sensitive to aging. With aging, BMSCs acquire a differentiation potential bias in favor adipogenesis over osteogenesis, and underlying molecular mechanisms remain unclear. Herein, we investigated factors age-related changes their roles BMSCs' differentiation. Antibody array revealed that CC chemokine ligand 3 (CCL3) accumulation occurred serum naturally aged mice along with aging phenotypes,...
Abstract In the last three years, capacity of health care systems and public policies governments worldwide were challenged by spread SARS-CoV-2. Mortality due to SARS-CoV-2 mainly resulted from development acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). Moreover, millions people who survived ALI/ARDS in infection suffer multiple inflammation-induced complications that lead disability even death. The lung-bone axis refers relationship between inflammatory diseases (COPD,...
Background: Lumbrokinase (LK) is an enzyme complex with antithrombotic, antioxidant, antitumor, and immunomodulatory effects. It has been extensively studied used in clinical anti-tumor therapy. However, its half-life short, bioavailability low, toxicity side effects are great, which greatly limit application. Therefore, LK often combined other drugs (such as immune agents, hormones, or Chinese herbal medicine) to reduce dosage improve Methods results: Here, we described LK/paclitaxel (PTX)...