A5052109744- Neurotransmitter Receptor Influence on Behavior
- Epigenetics and DNA Methylation
- Neuroscience and Neuropharmacology Research
- RNA regulation and disease
- Connexins and lens biology
- Cancer-related gene regulation
- Skin and Cellular Biology Research
- Immune Cell Function and Interaction
- Wnt/β-catenin signaling in development and cancer
- RNA and protein synthesis mechanisms
- melanin and skin pigmentation
- Inflammatory mediators and NSAID effects
- Metabolism, Diabetes, and Cancer
- Dermatologic Treatments and Research
- RNA Research and Splicing
- Skin Protection and Aging
- Receptor Mechanisms and Signaling
- Pain Mechanisms and Treatments
- Trace Elements in Health
- Genomics, phytochemicals, and oxidative stress
- Cell Adhesion Molecules Research
- Adipose Tissue and Metabolism
- Impact of Technology on Adolescents
- Biochemical Analysis and Sensing Techniques
- Parkinson's Disease Mechanisms and Treatments
Hainan Medical University
2020-2024
Nanjing Normal University
2024
Seoul National University
2014-2024
Seoul National University Hospital
2014-2022
Hainan Medical College Hospital
2019-2022
Biomedical Research Institute
2021
Central South University
2019-2020
First Hospital of Jiaxing
2016-2018
Jiaxing University
2016-2018
Anhui Medical University
2005-2016
A partial physical map has been constructed of the human class Mu glutathione <i>S</i>-transferase genes on chromosome 1p13.3. The in this cluster are spaced about 20 kilobase pairs (kb) apart, and arranged as 5′-<i>GSTM4</i>–<i>GSTM2</i>–<i>GSTM1</i>–<i>GSTM5</i>-3′. This used to localize end points polymorphic<i>GSTM1</i> deletion. left repeated region is 5 kb downstream from 3′-end <i>GSTM2</i> gene upstream beginning <i>GSTM1</i> gene; right 10 5′-end <i>GSTM5</i> gene. The<i>GSTM1</i>-0...
The underlying association between educational attainment (EA) and chronic pain (CP) risk is not clear. This study aimed to investigate the causal relationship of EA with CP using Mendelian randomization (MR). Single nucleotide polymorphisms (SNPs) for were selected from Social Science Genetic Association Consortium (SSGAC). Inverse-variance weighted (IVW), median, penalized maximum likelihood (ML), MR-Egger methods used estimate effects. Two sample MR analyses undertaken assess whether has...
Dyschromatosis symmetrica hereditaria (DSH) is an autosomal dominant pigmentary genodermatosis characterized by hyperpigmented and hypopigmented macules of on the extremities caused mutations in ADAR gene(also called DSRAD) encoding for RNA-specific adenosine deaminase. Here we reported clinical molecular findings 6 Chinese multi-generation families 2 sporadic patients with DSH. We found that same mutation could lead to different phenotypes even family did not establish a clear correlation...
<h3>Objective</h3> To report and analyze the mutations of double-stranded RNA–specific adenosine deaminase (<i>DSRAD</i>) gene in 2 Chinese pedigrees with dyschromatosis symmetrica hereditaria (DSH). <h3>Design</h3> Pedigree study. <h3>Setting</h3> Anhui province China. <h3>Patients</h3> Two families, consisting 19 individuals (family 1) 5 2). <h3>Interventions</h3> We directly performed mutation detection the<i>DSRAD</i>gene families DSH by sequencing. The whole coding region...
Background: Cancer-induced bone pain (CIBP) is one of the most challenging clinical problems due to a lack understanding mechanisms. Recent evidence has demonstrated that activation microglial G-protein-coupled P2Y 12 receptor (P2Y R) and proinflammatory cytokine production play an important role in neuropathic generation maintenance. However, whether R involved CIBP remains unknown. Methods: The purpose this study was investigate its molecular Using cancer model inoculated with Walker 256...
Chemokine, monocyte chemoattractant protein-1 (MCP-1), is a potential factor to cause cancer-induced bone pain (CIBP). NF-κB signaling very important in mediating the expression of chemokines and may have role CIBP. However, mechanism still unclear. This study investigates CIBP by regulating MCP-1/chemokine CC motif receptor-2 (CCR2) pathway.A rat model was established injecting Walker-256 cells into tibia medullary cavity. Nine days later, animals were intrathecally administrated with MCP-1...
The study of genomic divergence between humans and primates may provide insight into the origins human beings genetic basis unique traits diseases. Chromosome 21 is smallest chromosome in genome, some its regions have been implicated mental retardation other In this study, we sequenced coding regulatory 127 known genes on DNA samples from chimpanzees a part corresponding orangutan, gorilla, macaque. Overall, 3,003 nucleotide differences chimpanzee were identified over ≈400 kb. coding,...
Disseminated superficial actinic porokeratosis (DSAP) is an uncommon autosomal dominant chronic keratinization disorder, characterized by multiple keratotic lesions surrounded a slightly raised border. Thus far, although two loci for DSAP have been identified, the genetic basis and pathogenesis of this disorder not elucidated yet. In study, we performed genome-wide linkage analysis in three Chinese affected families localized gene 8.0 cM interval defined D12S330 D12S354 on chromosome 12....
Summary Background As an oil production byproducts, the shell of Camellia oleifera Abel (SC) is usually discarded in dump. However, previous investigations suggested that SC could provide valuable bioactive materials. Objective The objectives this study were to examine ability extract inhibit vitro tyrosinase activity and melanin inhibition effects cosmetic formulations containing 1,3‐butanediol human volunteers. Methods cell viability was determined using a WTT assay. A mushroom used...
Fear responses significantly affect daily life and shape our approach to uncertainty. However, the potential resurgence of fear in unfamiliar situations poses a significant challenge exposure-based therapies for maladaptive responses. Nonetheless, how novel contextual stimuli are associated with relapse extinguished remains unknown. Using context-dependent renewal model, functional circuits underlying mechanisms posterior parietal cortex (PPC) anterior cingulate (ACC) were investigated using...
This study aimed at evaluating the quality of fig wines that co-fermented by three non-Saccharomyces. Four suitable ratios were selected for co-fermentation, and fermentation performance was compared with juice pure Saccharomyces. HPLC used to analyze organic acids mono-phenols in wines, amino acid analyzer detect free acids. The results showed fermented non-Saccharomyces had higher contents mono-phenols. HS-SPME-GC/MS 48 aroma compounds revealed co-fermentation could obtain up 38 compounds,...