A5045439065- Advanced biosensing and bioanalysis techniques
- Catalysis for Biomass Conversion
- MicroRNA in disease regulation
- Magnesium Alloys: Properties and Applications
- Psoriasis: Treatment and Pathogenesis
- T-cell and B-cell Immunology
- Electrochemical sensors and biosensors
- Mesoporous Materials and Catalysis
- Dermatology and Skin Diseases
- RNA Interference and Gene Delivery
- Corrosion Behavior and Inhibition
- Advancements in Battery Materials
- Esophageal Cancer Research and Treatment
- Hydrogen Storage and Materials
- Electrochemical Analysis and Applications
- interferon and immune responses
- CRISPR and Genetic Engineering
- Monoclonal and Polyclonal Antibodies Research
- Aluminum Alloys Composites Properties
- Immune Cell Function and Interaction
- Graphene research and applications
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Zeolite Catalysis and Synthesis
- Respiratory viral infections research
Anhui Medical University
2002-2025
First Affiliated Hospital of Anhui Medical University
2007-2025
Soochow University
2015-2025
Hebei Medical University
2024-2025
Fourth Hospital of Hebei Medical University
2024-2025
Jiangsu University
2025
First People's Hospital of Kunshan
2025
China University of Mining and Technology
2023-2025
Zunyi Normal College
2025
Chinese Academy of Fishery Sciences
2022-2024
Polo-like kinase 1 (Plk1) is a crucial regulator of cell cycle progression; but the mechanism regulation Plk1 activity not well understood. We present evidence that controlled by balanced methylation and phosphorylation switch. The methyltransferase G9a monomethylates at Lys209, which antagonizes T210 to inhibit activity. found methyl-deficient mutant K209A affects DNA replication, whereas methyl-mimetic K209M prolongs metaphase-to-anaphase duration through inability sister chromatids...
TGF-β has been demonstrated to promote tumor metastasis, and the regulatory mechanisms are poorly understood. Here, we report role of USP2a in promoting metastasis by facilitating TGF-β-triggered signaling. interacts with TGFBR1 TGFBR2 upon stimulation removes K33-linked polyubiquitin chains from Lys502 TGFBR1, recruitment SMAD2/3. Simultaneously, phosphorylates Ser207/Ser225 USP2a, leading disassociation SMAD2/3 TGFBR1. The phosphorylation SMAD2 is positively correlated human biopsies,...
Immunotherapy combined with chemoradiotherapy has demonstrated promising efficacy in stage III non-small-cell lung cancer (NSCLC). However, the optimal timing for immunotherapy intervention during radiotherapy remains unclear. This study aimed to compare and safety of immune checkpoint inhibitors (ICIs) administered concurrently or sequentially unresectable NSCLC. A retrospective analysis 98 patients NSCLC, treated between January 1, 2019, June 30, 2023, was conducted. Patients were grouped...
To develop a nomogram based on the radiomics features of tumour and perigastric adipose tissue adjacent to tumor in dual-layer spectral detector computed tomography (DLCT) for lymph node metastasis (LNM) prediction gastric cancer (GC). A retrospective analysis was conducted 175 patients with adenocarcinoma. They were divided into training cohort (n = 125) validation 50). The from fat DLCT images extracted construct models LNM using Lasso-GLM method. Preoperative clinicopathological features,...
In industrial environments, slurry density detection models often suffer from performance degradation due to concept drift. To address this, this article proposes an intelligent method tailored for in drift data streams. The begins by building a model using Gaussian process regression (GPR) combined with regularized stochastic configuration. A sliding window-based online GPR is then applied update the linear model's parameters, while forgetting mechanism enables recursive updates nonlinear...
The abnormal expression of hydrogen peroxide (H 2 O ) in living cells is closely related to the occurrence and development tumor diseases. It a kind potential marker for diagnosis treatment Therefore, it very meaningful develop high selective sensitive method real‐time detecting H released from cancer cells. Herein, an AgCl cube/porous carbon nanotube composite nanomaterials was successfully fabricated employed construct non‐enzymatic electrochemical sensor. Test results showed that proposed...
A metal-free amination of alkenes based on maleimides has been developed. This method features mild reaction conditions and broad substrate scope, aminomaleimides with EWGs have synthesized in up to 99% yield. The gram-scale successful derivatization the products further demonstrate applicability this methodology.
Prematurity is more prevalent in African Americans than European Americans. We investigated the contribution of a functional SNP promoter SERPINH1 gene, enriched among those ancestry, to preterm premature rupture membranes (PPROM), leading identifiable cause birth. encodes heat-shock protein 47, chaperone essential for collagen synthesis. The −656 minor T allele had greater frequency populations and (12.4% vs. 4.1%). displayed significantly reduced activity compared major C amnion...
Objective: This study aims to investigate perinatal depression in women who gave birth during the COVID-19 pandemic Wuhan, and evaluate effect of on prevalence. Methods: A cross-sectional investigation was conducted into hospitalized for delivery Hubei Maternity Child Healthcare Hospital from December 31, 2019 March 22, 2020, a period which encompasses entire time frame Wuhan. The Edinburgh Postnatal Depression Scale (EPDS) adopted status. Chi-square test logistic regression model were...
Catalytic C–O bond hydrogenolysis is an essential route to produce sustainable chemicals and fuels from lignin its derivatives. Herein, various Ni-based catalysts were successfully prepared evaluated in the of lignin-derived diphenyl ether (DPE) benzyl phenyl (BPE). It found that 10%Ni/α-Al2O3 shows highest activity for cleaving bonds DPE BPE at low reaction temperatures H2 pressures. Compared 10%Ni/γ-Al2O3 10%Ni/γ-Al2O3-2, exhibits a higher initial rate conversion BPE. Different...
E-cadherin is a key cell-to-cell adhesion molecule associated with the invasion and metastasis of tumor cells; however, molecular mechanisms are not entirely understood. In this study, we investigated whether downregulation by E-cadherin-specific small intefering RNA (siRNA) was able to promote malignant phenotypes prostate cancer cells through upregulating metastasis-associated gene 1 (MTA1) in vitro. The expression levels human paired adenocarcinoma cell lines, PC-3M-2B4 (2B4) PC-3M-1E8...
A facile strategy has been reported to anchor silver nanoparticles (Ag NPs) onto three-dimensional reduced graphene oxide (3D rGO) via a green and simple method. An accurate reliable electrochemical sensing platform based on Ag NPs/3D rGO was designed for the ultrasensitive detection of rifampicin (RIF). The morphology features were characterized by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), Raman measurements. interface modified...
Carbon monoxide (CO), hypothetically linked to prebiotic biosynthesis and possibly the origin of life, emerges as a substantive growth substrate for numerous microorganisms. In anoxic environments, coupling CO oxidation with hydrogen (H
Elucidating cellular architecture and cell-type evolution across species is central to understanding immune system function susceptibility disease. Adaptive immunity a shared trait of the common ancestor cartilaginous bony fishes. However, evolutionary features lymphocytes in these two jawed vertebrates remain unclear. Here, we present single-cell RNA sequencing atlas cells from (white-spotted bamboo shark) (zebrafish Chinese tongue sole) Cross-species comparisons show that same cell types...