Although generally considered competitive, the alkenylation and carbonyl olefination routes to alkenes are also complementary. In this Account, we focus on these approaches for synthesis of regio- stereodefined di- trisubstituted a few examples tetrasubstituted alkenes. We discuss subset dienes oligoenes that conjugated. Pd-catalyzed cross-coupling using alkenyl metals containing Zn, Al, Zr, B (Negishi coupling Suzuki coupling) or halides related electrophiles provides method with widest...

Palladium-catalyzed cross-coupling reactions, especially those involving Zn, Al, Zr (Negishi coupling), and B (Suzuki collectively have brought about "revolutionary" changes in organic synthesis. Thus, two regio- stereodefined carbon groups generated as R1M (M = B, Cu, Zr, etc.) R2X (X I, Br, OTs, may now be cross-coupled to give R1−R2 with essentially full retention of all structural features. For alkene syntheses, alkyne elementometalation reactions including hydrometalation (B, etc.),...

A general and facile synthetic method for C(sp2)–H difluoroalkylations perfluoroalkylations of alkenes (hetero)arenes with commercially available fluoroalkyl halides has been developed a copper-amine catalyst system. This is characterized by high yields, mild reaction conditions, low-cost catalyst, broad substrate scope, excellent functional group compatibility, therefore providing convenient strategy toward various difluoroalkyl- perfluoroalkyl-substituted (hetero)arenes.

An efficient BF3·OEt2-mediated propargyl alcohol rearrangement/[1,5]-hydride transfer/cyclization cascade for the synthesis of tetrahydroquinoline derivatives has been described. The substituents adjacent to triple bonds play an important role in formation ketones (via [1,3]-hydroxyl shift) or alkenyl fluorides which are products formal trans-carbofluorination internal alkynes. This method provides a rapid access diverse heterocycles moderate excellent yields.

Three chiral pyrrolidine functionalized polyacrylonitrile fiber catalysts have been designed, prepared, and evaluated for their catalytic performance in asymmetric Michael addition of ketones to nitrostyrenes water.

Here we present a novel annulation of pyridinium salts with BrCF2CO2Et to access the indolizine derivatives high efficiency. The α substitution pyridine plays key role in determining reaction pathways. Various types indolizines can be conveniently accessed from easily available under mild and simple conditions.

Photoinduced interfacial release of volatile organic compounds (VOCs) from surfactants receives emerging concerns. Here, we investigate the photoreaction 1-nonanol (NOL) as a model surfactant at air-water interface, especially for important role 1O2 in formation VOCs. The production VOCs is real-time quantitated. results indicate that oxygen content apparently affects total yields during NOL. photoactivity NOL about 8 times higher under air than nitrogen, which mainly attributed to...

Abstract: The allylation reaction of Morita-Baylis-Hillman carbonates is an effective method for constructing C-C bonds. Yang's group has utilized azomethine ylides, which are generated in situ from 2-aminomalonate and ortho-amino benzaldehydes, to engage reactions with MBH carbonates. Despite the initial substrate specificity that confined rendering benzaldehyde salicylaldehyde ineffective producing desired adducts, our made a significant advancement. By employing diethyl amino malonate...

The allylation of carbonyl compounds to form homoallylic alcohols represents one the significant synthetic transformations. In this letter, we describe a new method for aldehydes with allyl facilitated by nickel chloride and tetrahydroxydiboron. This approach offers mild straightforward procedure synthesis from ketones.

Raindrops on the windscreen significantly impact a driver's visibility during driving, affecting safe driving. Maintaining clear is crucial for drivers to mitigate accident risks in rainy conditions. A real-time rain detection system and an innovative wiper control method are introduced based machine vision deep learning. An all-weather raindrop model constructed using convolutional neural network (CNN) architecture, utilising improved YOLOv8 model. The achieved precision rate of 0.89,...

A metal-free amination of alkenes based on maleimides has been developed. This method features mild reaction conditions and broad substrate scope, aminomaleimides with EWGs have synthesized in up to 99% yield. The gram-scale successful derivatization the products further demonstrate applicability this methodology.

The homocoupling of terminal alkynes is a key approach for constructing 1,3‐diynes , typically relying on copper‐based bimetallic systems. Herein, we have developed catalytic system based nickel chloride, using 1,10‐phenanthroline as the ligand and air oxidant, which successfully enables reactions various alkynes. This reaction characterized by cheap stable NiCl2 catalyst, mild conditions excellent functional group compatibility, demonstrating great potential practical applications.

A solvent- and temperature-controlled diastereodivergent [4+2] cyclization between para-quinone methides (p-QMs) 4-benzylidene-pyrazolones has been developed. This method enabling the synthesis of three diastereomers a spirochromene skeleton with three...

All four stereoisomers ( 7 – 10 ) of ethyl undeca-2,4-dienoate were prepared in ≥98% isomeric purity by Pd-catalyzed alkenylation (Negishi coupling) using E )- and Z β -bromoacrylates. Although the stereoisomeric 2 ,4 -isomer 8 Suzuki coupling conventional alkoxide carbonate bases was ≤ 95%, as reported earlier, use CsF or n Bu 4 NF a promoter base has now been found to give all selectivity. Other widely known methods reveal considerable limitations. Heck satisfactory for syntheses isomers...

Abstract Unprecedentedly efficient and highly (≥98 %) stereoselective syntheses of mycolactones A B side chains relied heavily on Pd‐catalyzed alkenylation (Negishi version) were completed in 11 longest linear steps from ethyl ( S )‐3‐hydroxybutyrate 12 % overall yield, respectively, roughly corresponding to an average 82 yield per step. The synthesis mycolactone core was realized by using alkenylallyl coupling epoxide‐opening reaction with a trialkylalkenylaluminate as key steps. Fully...

Highly efficient, easily recyclable and reusable polyacrylonitrile fiber-supported quaternary ammonium salts for the reduction of aldehydes, ketones, azides, benzyl halides in water using NaBH₄ as reducing reagent.

A visible-light-induced and copper-promoted perfluoroalkylation of benzamides was successfully developed under the assistance an 8-aminoquinoline directing group. It provides a straightforward method for synthesis ortho-perfluoroalkyl-substituted benzoic acid derivatives. The reaction employs cheap organic dye eosin Y as photoredox catalyst is run irradiation 26 W fluorescent LED light bulb.

A general and facile synthetic method for β-fluoroenones from silyl enol ethers or ketones, with a copper-amine catalyst system, has been developed. The reaction proceeded by tandem process of difluoroalkylation-hydrolysis-dehydrofluorination. This is characterized high yields, excellent Z/E ratios, low-cost catalyst, broad substrate scope. potential demonstrated the construction various complicated organofluorine molecules.

An efficient approach to α,α-difluoro-γ-lactam derivatives was developed using a copper/amine catalyst <italic>via</italic> tandem radical cyclization pathway.

Ambipolar organic field-effect transistors (OFETs) are vital for the construction of high-performance all-organic digital circuits. The bilayer p-n junction structure, which is composed separate layers p- and n-type semiconductors, considered a promising way to realize well-balanced ambipolar charge transport. However, this approach suffers from severely reduced mobility due rough interface between polycrystalline thin films semiconductors. Herein, 2D molecular crystal (2DMC) junctions...