A5053198393- Connexins and lens biology
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Advanced Glycation End Products research
- Neurological Disease Mechanisms and Treatments
- Ubiquitin and proteasome pathways
- Retinal Development and Disorders
- Ocular Diseases and Behçet’s Syndrome
- Genomics, phytochemicals, and oxidative stress
- Neuroinflammation and Neurodegeneration Mechanisms
- Toxoplasma gondii Research Studies
- Ocular Disorders and Treatments
- Endoplasmic Reticulum Stress and Disease
- Glutathione Transferases and Polymorphisms
- Inflammasome and immune disorders
- Retinal and Optic Conditions
- Systemic Lupus Erythematosus Research
- Heat shock proteins research
- Echinoderm biology and ecology
- Retinopathy of Prematurity Studies
- Autoimmune and Inflammatory Disorders Research
- Redox biology and oxidative stress
- Advanced Fiber Laser Technologies
- Advanced Chemical Sensor Technologies
- Smart Grid Security and Resilience
Chinese Academy of Fishery Sciences
2024-2025
Qingdao National Laboratory for Marine Science and Technology
2024
Harvard University
2020-2023
Smith-Kettlewell Eye Research Institute
2020-2023
Massachusetts Eye and Ear Infirmary
2020-2023
East China Normal University
2022
Tufts University
2014-2021
Henan Normal University
2021
Inner Mongolia People's Hospital
2011-2020
Sun Yat-sen University
2009-2020
Age-related macular degeneration (AMD) is the major cause of blindness in developed nations. AMD characterized by retinal pigmented epithelial (RPE) cell dysfunction and loss photoreceptor cells. Epidemiologic studies indicate important contributions dietary patterns to risk for AMD, but mechanisms relating diet disease remain unclear. Here we investigate effect on isocaloric diets that differ only type carbohydrate a wild-type aged-mouse model. The consumption high-glycemia (HG) resulted...
CC-Cruiser is an artificial intelligence (AI) platform developed for diagnosing childhood cataracts and providing risk stratification treatment recommendations. The high accuracy of was previously validated using specific datasets. objective this study to compare the diagnostic efficacy decision-making capacity between ophthalmologists in real-world clinical settings.This multicentre randomized controlled trial performed five ophthalmic clinics different areas across China. Pediatric...
Significance Eye lens opacification or cataract is the most prevalent age-related disease, blinding 18 million people. Cataractogenesis involves accumulation and precipitation of damaged proteins from normally clear lens. The ubiquitin proteolytic system main cytoplasmic degradative pathway that charged with selectively removing proteins. Ubiquitin has seven lysines. Although lysine 6 involved in less than 3% conjugates we find few changes when unavailable, observed mutating alters cell...
Microglia shift toward an inflammatory phenotype during aging that is thought to exacerbate age-related neurodegeneration. The molecular and cellular signals resolve neuroinflammation post-injury are largely undefined. Here, we exploit systems genetics methods based on the extended BXD murine reference family identify IGFBPL1 as upstream cis-regulator of microglia-specific genes switch off inflammation. expressed by mouse human microglia, higher levels its expression...
Elucidating cellular architecture and cell-type evolution across species is central to understanding immune system function susceptibility disease. Adaptive immunity a shared trait of the common ancestor cartilaginous bony fishes. However, evolutionary features lymphocytes in these two jawed vertebrates remain unclear. Here, we present single-cell RNA sequencing atlas cells from (white-spotted bamboo shark) (zebrafish Chinese tongue sole) Cross-species comparisons show that same cell types...
Galectins have emerged as potent immunoregulatory agents that control chronic inflammation through distinct mechanisms. Here, we report treatment with Galectin-8 (Gal-8), a tandem-repeat member of the galectin family, reduces retinal pathology and prevents photoreceptor cell damage in murine model experimental autoimmune uveitis. Gal-8 increased number regulatory T cells (Treg) both draining lymph node (dLN) inflamed retina. Moreover, greater percentage Treg dLN retina treated animals...
Failure of lens fiber cell denucleation (LFCD) is associated with congenital cataracts, but the pathobiology awaits elucidation. Recent work has suggested that mechanisms direct unidirectional process LFCD are analogous to cyclic processes mitosis. We found lens-specific mutations elicit an unfolded-protein response (UPR) in vivo accumulate p27(Cdkn1b), show cyclin-dependent kinase (Cdk)-1 inhibition, retain their LFC nuclei, and cataractous. Although a UPR was not detected lenses expressing...
Single-photon laser ranging has widespread applications in remote sensing and target recognition. However, highly sensitive light detection (lidar) long been restricted the visible or near-infrared bands. An appealing quest is to extend operation wavelength into mid-infrared (MIR) region, which calls for an infrared photon-counting system at high sensitivity precise temporal resolution. Here, we devise demonstrate MIR upconversion lidar based on nonlinear asynchronous optical sampling....
<h3>Purpose</h3> Patients with Vogt–Koyanagi–Harada (VKH) disease are known to have severe inflammation after cataract surgery. This study was designed investigate the role of IL-17-producing T helper (Th17) cell-related pro-inflammatory cytokines on postoperative in VKH patients. <h3>Methods</h3> Serum from nine patients and controls age-related or congenital collected before 1, 7, 30 90 days surgery, aqueous humor (AqH) at commencement Protein levels IL-23, IL-27, IL-17 IFN-γ serum AqH...
Purpose: Age-related cataracts affect the majority of older adults and are a leading cause blindness worldwide. Treatments that delay cataract onset or severity have potential to surgery, but require relevant animal models recapitulate major types for their development. Unfortunately, few such available. Here, we report lens phenotypes aged mice lacking critical antioxidant transcription factor Nfe2l2 (designated as Nrf2 −/−). Methods: Three independent cohorts −/− wild-type C57BL/6J were...
We report a passive stabilization of the repetition rate for mode-locked fiber laser by using an electro-optic modulator in phase-biased nonlinear amplifying loop mirror. The underlying mechanism, contrast to active feedback operations, lies cross-phase modulation between electrical and optical pulses within crystal. resulting spectral shift can automatically compensate cavity-length drift via group velocity dispersion. Consequently, artificial actuator enables capture range up 2.3 mm, much...
The aim of this study was to evaluate the clinical features and visual results fireworks-related ocular burn injuries determine prognostic factors. authors conducted a prospective observational 53 eyes 46 consecutive patients with injury who visited Zhongshan Ophthalmic Center during Spring Festival in Southern China. Eyes were graded using an trauma classification system, which included age patient. Patients followed up for minimum 5 months. Best-corrected acuity at last follow-up...
Chronic exposure to n-hexane may result in peripheral neuropathy. 2,5-Hexanedione (2,5-HD) has been identified as a toxic metabolite of n-hexane. The CYP2E1, CYP1A1 and GST genes are involved the formation 2,5-hexanedione from well elimination 2,5-HD-formed electrophile, these highly polymorphic general population. A nested case-control study an industrial cohort was conducted evaluate associations between polymorphisms metabolic n-hexane-induced nerve damage. subjects included 22 cases, who...
Diabetic retinopathy (DR) is one of the most common microvascular complications diabetes. The present study aimed to identify a possible connection between gene polymorphisms and risk developing DR.A total 319 patients with type 2 diabetes mellitus (T2DM) were selected. All underwent complete eye examination. Based on this, T2DM divided into two subgroups: 175 144 without (NDR). We calculated genotype frequencies case control subjects using chi-squares test. odds ratio (OR) 95% confidence...