A5041339638- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Retinopathy of Prematurity Studies
- Retinal Development and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Ophthalmology and Visual Impairment Studies
- Neonatal Respiratory Health Research
- Retinal and Macular Surgery
- Functional Brain Connectivity Studies
- Optical Coherence Tomography Applications
- Advanced Neuroimaging Techniques and Applications
- Medical History and Innovations
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- History of Medical Practice
- Laser Applications in Dentistry and Medicine
- Neonatal and fetal brain pathology
- History of Medicine Studies
- Visual perception and processing mechanisms
- Neonatal Health and Biochemistry
- Vascular Malformations Diagnosis and Treatment
- Aging and Gerontology Research
- Ophthalmology and Visual Health Research
Duke Medical Center
2015-2024
Duke University
2014-2024
Duke University Hospital
2016-2024
Durham Technical Community College
2023
Eye Center
2022
Ophthalmology Associates (United States)
2013
Stanford University
2007-2011
Menlo School
2008
Stanford Medicine
2007
Outer retinal degenerations, including age-related macular degeneration (AMD), are characterized by photoreceptor and pigment epithelium (RPE) atrophy. In these blinding diseases, macrophages accumulate at atrophic sites, but their ontogeny niche specialization remain poorly understood, especially in humans. We uncovered a unique profile of microglia, marked galectin-3 upregulation, sites mouse models human AMD. disease models, conditional deletion microglia led to phagocytosis defects...
Inner retina in Alzheimer's Disease (AD) may experience neuroinflammation resulting atrophy. The objective of our study was to determine whether retinal GCIPL (ganglion cell-inner plexiform layer) or nerve fiber layer (NFL) thickness serve as noninvasive biomarkers diagnose AD. This cross-sectional case-control enrolled 15 mild cognitive impairment (MCI) patients, mild-moderate AD and 18 cognitively normal adults. NFL thicknesses on optical coherence tomography (OCT) were measured using Duke...
To assess visual function outcomes to 48 weeks in patients with bilateral geographic atrophy (GA) secondary age-related macular degeneration included 2 interventional clinical trials: relationship baseline lesion size, by characteristic subgroups, and correlation of GA area.The Chroma Spectri studies (ClinicalTrials.gov identifiers, NCT02247479 NCT02247531, respectively) were identically designed phase 3, double-masked, multicenter, randomized, sham injection-controlled trials that evaluated...
Diabetic retinopathy (DR) is a leading cause of blindness in working-age adults and remains an important public health issue worldwide. Here we demonstrate that the expression stimulator interferon genes (STING) increased patients with DR animal models diabetic eye disease. STING has been previously shown to regulate cell senescence inflammation, key contributors development progression DR. To investigate mechanism whereby contributes pathogenesis DR, diabetes was induced STING-KO mice...
<h3>Aims</h3> To determine the incidence of retinopathy prematurity (ROP) based upon a national database and to identify baseline characteristics, demographic information, comorbidities, surgical interventions. <h3>Methods</h3> The National Inpatient Sample, representative sample all US hospital discharges from 1997 2002, was queried for newborn infants with without ROP. Primary outcome variables included demographics, length stay (LOS), charges. Multivariate logistic regression used predict...
To evaluate the effect of select baseline characteristics on geographic atrophy (GA) progression in eyes receiving intravitreal pegcetacoplan or sham.Phase 2 multicenter, randomized, single-masked, sham-controlled trial.Patients with GA received 15 mg monthly every other month (EOM), sham injection EOM for 12 months. Primary efficacy endpoint was change lesion size (square root) from baseline. Post hoc analysis evaluated effects age; gender; size, focality, and location (extrafoveal vs...
Purpose: The LIGHTSITE III study evaluated multiwavelength photobiomodulation (PBM) therapy in nonexudative (dry) AMD using the LumiThera Valeda ® Light Delivery System. Methods: is a randomized, controlled trial to assess safety and effectiveness of PBM dry AMD. Subjects were treated with (590, 660 850 nm) or Sham treatment delivered 9 treatments over 3-5 weeks every four months 24 months. assessed for efficacy outcomes. Data from 13-month analysis are presented this report. Results: A...
Age-related macular degeneration (AMD) has recently been linked to cognitive impairment. We hypothesized that AMD modifies the brain aging trajectory, and we conducted a longitudinal diffusion MRI study on 40 participants (20 with 20 controls) reveal location, extent, dynamics of AMD-related changes. Voxel-based analyses at first visit identified reduced volume in cuneate gyrus, associated vision, temporal bilateral cingulate higher cognition memory. The second occurred 2 years after...
The peripheral retina of the human eye offers a unique opportunity for assessment and monitoring ocular diseases. We have developed novel wide-field (>70°) optical coherence tomography system (WF-OCT) equipped with wavefront sensorless adaptive optics (WSAO) enhancing visualization smaller (<25°) targeted regions in retina. iterated WSAO algorithm at speed individual OCT B-scans (~20 ms) by using raw spectral interferograms to calculate optimization metric. Our approach 3 mm beam diameter...
Purpose: The purpose of this study was to evaluate baseline best corrected visual acuity (BCVA), full-field electroretinography (ERG), stimulus thresholds (FST), and their relationship with demographic clinical characteristics in the Rate Progression Usher syndrome type 2 (USH2A)-related Retinal Degeneration (RUSH2A) multicenter study. Methods: Participants had (USH2, N = 80) or autosomal recessive nonsyndromic retinitis pigmentosa (ARRP, 47) associated biallelic variants USH2A gene....