A5041940285- Frailty in Older Adults
- Retinal Imaging and Analysis
- Intensive Care Unit Cognitive Disorders
- Resilience and Mental Health
- Health disparities and outcomes
- Dementia and Cognitive Impairment Research
- Ophthalmology and Visual Impairment Studies
- Retinal Diseases and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Nutrition and Health in Aging
- Chronic Disease Management Strategies
- Anesthesia and Neurotoxicity Research
- Geriatric Care and Nursing Homes
- Cardiac, Anesthesia and Surgical Outcomes
- Glaucoma and retinal disorders
- Anesthesia and Sedative Agents
- Hearing Loss and Rehabilitation
- Functional Brain Connectivity Studies
- Noise Effects and Management
- Emergency and Acute Care Studies
- Alzheimer's disease research and treatments
- Retinal and Optic Conditions
- Health and Well-being Studies
- Aging and Gerontology Research
- Cerebral Palsy and Movement Disorders
Duke Medical Center
2016-2025
Geriatric Research Education and Clinical Center
2016-2025
Duke University
2016-2025
Durham VA Medical Center
2016-2025
Durham VA Health Care System
2019-2025
Duke University Hospital
2015-2024
University of North Carolina at Chapel Hill
2023-2024
Duke University Health System
2022
Institute of Behavioral Sciences
2021
Institute of Population and Public Health
2021
This article summarizes the presentations and recommendations of tenth annual American Geriatrics Society National Institute on Aging Bench-to-Bedside research conference, "Sensory Impairment Cognitive Decline," October 2-3, 2017, in Bethesda, Maryland. The risk impairment hearing, vision, other senses increases with age, almost 15% individuals aged 70 older have dementia. As number adults increases, sensory cognitive impairments will affect a growing proportion population. To limit its...
OBJECTIVES: To determine whether frail older adults, based on a deficit accumulation index (DAI), are at greater risk of adverse outcomes after discharge from the emergency department (ED). DESIGN AND SETTING: Secondary analysis data Medicare Current Beneficiary Survey. PARTICIPANTS: One thousand eight hundred fifty‐one community‐dwelling fee‐for‐service enrollees, aged 65 and who were discharged ED between January 2000 September 2002. MEASUREMENTS: The primary dependent variable was time to...
IMPORTANCEOlder adults undergoing elective surgery experience higher rates of preventable postoperative complications than younger patients.OBJECTIVE To assess clinical outcomes for older abdominal via a collaborative intervention by surgery, geriatrics, and anesthesia focused on perioperative health optimization. DESIGN, SETTING, AND PARTICIPANTSPerioperative Optimization Senior Health (POSH) is quality improvement initiative with prospective data collection.Participants in an existing...
Resilience, the ability to resist or recover from adverse effects of a stressor, is widespread interest in social, psychologic, biologic, and medical research particularly salient as capacity respond stressors becomes diminished with aging. To date, on human resilience responses factors influencing these has been limited.The National Institute Aging convened workshop August 2015 needs for improve measures predict assess Effects aging-related impairing homeostatic were developed examples...
Objectives To define multimorbidity “classes” empirically based on patterns of disease co‐occurrence in older Americans and to examine how class membership predicts healthcare use. Design Retrospective cohort study. Setting Nationally representative sample Medicare beneficiaries file years 1999–2007. Participants Individuals aged 65 the Beneficiary Survey who had data available for at least 1 year after index interview (N = 14,052). Measurements Surveys (self‐report) were used assess chronic...
Abstract There is limited research examining the impact of visual impairment (VI) on older adults while considering complexities aging, leaving gaps in our understanding how health consequences VI might be averted. We created a framework integrating concepts from disability, geriatrics, and ophthalmology that conceptualizes challenges successful aging. Here, influences multiple functional domains, increases risk negative outcomes. This model acknowledges common causes, such as factors affect...
Inner retina in Alzheimer's Disease (AD) may experience neuroinflammation resulting atrophy. The objective of our study was to determine whether retinal GCIPL (ganglion cell-inner plexiform layer) or nerve fiber layer (NFL) thickness serve as noninvasive biomarkers diagnose AD. This cross-sectional case-control enrolled 15 mild cognitive impairment (MCI) patients, mild-moderate AD and 18 cognitively normal adults. NFL thicknesses on optical coherence tomography (OCT) were measured using Duke...
Dementia prevention is a high priority, given the large impact of dementia on well-being individuals and society. The number older adults with in US globally projected to increase as result population aging growth. Thus, it vital identify potentially modifiable risk factors. Vision impairment has been identified factor for accelerated cognitive decline incident dementia. An estimated 90% vision preventable or yet be treated. Nevertheless, not included dominant life-course models factors used...
Although animal models suggest a role for blood-brain barrier dysfunction in postoperative delirium-like behavior, its delirium and recovery humans is unclear. Thus, we evaluated the of hospital length stay among older surgery patients.
OBJECTIVES: To determine the risk of disability in individuals with coexisting visual and cognitive impairment to compare magnitude associated impairment, or multimorbidity. DESIGN: Prospective cohort. SETTING: North Carolina. PARTICIPANTS: Three thousand eight hundred seventy‐eight participants Carolina Established Populations for Epidemiologic Studies Elderly nonmissing status, status data at baseline MEASUREMENTS: Short Portable Mental Status Questionnaire (cognitive defined as≥4 errors),...
Older women experience disability more commonly than their male peers. This disparity may be due, in part, to sex-based differences the prevalence or disabling effects of common medical conditions. The objectives this analysis were (a) quantify extent which excess is explained by higher selected conditions and (b) evaluate whether same have differing on men women. We analyzed cross-sectional data from 5,888 community-dwelling older Disability was defined as difficulty with greater equal one...
Every year, up to 40% of the more than 16 million older Americans who undergo anesthesia/surgery develop postoperative cognitive dysfunction (POCD) or delirium. Each these distinct syndromes is associated with decreased quality life, increased mortality, and a possible risk Alzheimer's disease. One pathologic process hypothesized underlie both delirium POCD neuroinflammation. The INTUIT study described here will determine extent which increases in cerebrospinal fluid (CSF) monocyte...
Abstract Objective Numerous investigators have theorized that postoperative changes in Alzheimer's disease neuropathology may underlie neurocognitive disorders. Thus, we determined the relationship between cognition and cerebrospinal ( CSF ) tau, p‐tau‐181p, or Aβ levels after non‐cardiac, non‐neurologic surgery older adults. Methods Participants underwent cognitive testing before 6 weeks surgery, lumbar punctures before, 24 h after, surgery. Cognitive scores were combined via factor...