A5009404411- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Cardiac, Anesthesia and Surgical Outcomes
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Neural and Behavioral Psychology Studies
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Attention Deficit Hyperactivity Disorder
- Neuroethics, Human Enhancement, Biomedical Innovations
- Herpesvirus Infections and Treatments
- Cognitive Functions and Memory
- Functional Brain Connectivity Studies
- Cancer-related molecular mechanisms research
- Mental Health Research Topics
- Psychology of Moral and Emotional Judgment
- Phosphodiesterase function and regulation
- Heart Rate Variability and Autonomic Control
- EEG and Brain-Computer Interfaces
- Neuroendocrine regulation and behavior
Stanford University
2025
Duke Medical Center
2022-2024
Duke University
2023-2024
Duke University Hospital
2022-2024
University of Oklahoma
2020-2024
Abstract Objective Numerous investigators have theorized that postoperative changes in Alzheimer's disease neuropathology may underlie neurocognitive disorders. Thus, we determined the relationship between cognition and cerebrospinal ( CSF ) tau, p‐tau‐181p, or Aβ levels after non‐cardiac, non‐neurologic surgery older adults. Methods Participants underwent cognitive testing before 6 weeks surgery, lumbar punctures before, 24 h after, surgery. Cognitive scores were combined via factor...
Anesthesia and/or surgery accelerate Alzheimer's disease pathology and cause memory deficits in animal models, yet there is a lack of prospective data comparing cerebrospinal fluid (CSF) disease-related biomarker cognitive trajectories older adults who underwent versus those have not. Thus, the objective here was to better understand whether anesthesia contribute decline or an acceleration adults.
Postoperative delirium is the most common postsurgical complication in older adults and associated with an increased risk of long-term cognitive decline Alzheimer's disease (AD) related dementias (ADRD). However, neurological basis this risk- whether postoperative unmasks latent preoperative pathology or leads to AD-relevant after perioperative brain injury-remains unclear. Recent advancements neuroimaging techniques now enable detection subtle features damage that may underlie clinical...
BackgroundIn the eyes-closed, awake condition, EEG oscillatory power in alpha band (7–13 Hz) dominates human spectral activity. With eyes open, however, substantially decreases. Less attenuation with opening has been associated inattention; thus, we analysed whether reduced preoperative is postoperative inattention, a delirium-defining feature.MethodsPreoperative 32-channel was recorded open and closed 71 non-neurological, noncardiac surgery patients aged ≥ 60 years. Inattention other...
The most common complication in older surgical patients is postoperative delirium (POD). POD associated with preoperative cognitive impairment and longer durations of intraoperative burst suppression (BSup) – electroencephalography (EEG) repeated periods (very low-voltage brain activity). However, BSup has modest sensitivity for predicting POD. We hypothesized that a state lowered EEG power immediately precedes BSup, which we have termed “pre-burst suppression” (preBSup). Further, even...
Abstract Fragile X syndrome (FXS) is a rare neurodevelopmental disorder caused by CGG repeat expansion ≥ 200 repeats in 5’ untranslated region of the FMR1 gene, leading to intellectual disability and cognitive difficulties, including domain communication. A recent phase 2a clinical trial testing BPN14770, phosphodiesterase 4D inhibitor, showed improved cognition 30 adult males with FXS on drug relative placebo. The initial study found significant improvements measures assessing cognition,...
Structured Abstract Background Postoperative delirium is the most common complication following surgery among older adults, and has been consistently associated with increased mortality morbidity, cognitive decline, loss of independence, as well markedly health-care costs. Electroencephalography (EEG) spectral slowing frequently observed during episodes delirium, whereas intraoperative frontal alpha power postoperative delirium. We sought to identify preoperative predictors that could...
Electroencephalography (EEG) allows for the evaluation of real time changes in brain (electrocortical) activity during exercise. A few studies have examined electrocortical using stationary cycling, but findings been mixed. Some these found increases following exercise, while others decreases Hence, it is importance to identify post-exercise activity. Sixteen healthy, untrained subjects (8 males; 8 females) participated study. All 16 participants performed a graded exercise test (GXT)...
<title>Abstract</title> Fragile X syndrome (FXS) is a rare neurodevelopmental disorder caused by CGG repeat expansion ≥ 200 repeats in 5’ untranslated region of the FMR1 gene, leading to intellectual disability and cognitive difficulties, including domain communication. A recent phase 2a clinical trial testing BPN14770, phosphodiesterase 4D inhibitor, showed improved cognition 30 adult males with FXS on drug relative placebo. The initial study found significant improvements measures...
Abstract Background Postoperative delirium (POD) is characterized by fluctuating attention after surgery and associated with increased risk of developing Alzheimer’s Disease (AD). While the neurophysiological changes that underlie POD AD are unclear, recent data has raised possibility an exaggerated brain response to anesthetics may be a biomarker for preclinical AD‐like pathology. Thus, we examined whether anesthetic‐dose‐adjusted intraoperative activity or preoperative vulnerabilities...