A5100347301- Metal complexes synthesis and properties
- Adrenal Hormones and Disorders
- Hormonal Regulation and Hypertension
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Advanced biosensing and bioanalysis techniques
- Ferrocene Chemistry and Applications
- Crystallization and Solubility Studies
- HIV/AIDS drug development and treatment
- X-ray Diffraction in Crystallography
- Gold and Silver Nanoparticles Synthesis and Applications
- Blood groups and transfusion
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Nutrition and Health in Aging
- Platelet Disorders and Treatments
- Infectious Diseases and Tuberculosis
- Cancer-related molecular mechanisms research
- Pituitary Gland Disorders and Treatments
- Quinazolinone synthesis and applications
- Magnetism in coordination complexes
- Glioma Diagnosis and Treatment
- Diabetes and associated disorders
- Breastfeeding Practices and Influences
- HIV-related health complications and treatments
City University of Hong Kong
2019-2025
Shanghai Changzheng Hospital
2018-2025
Chongqing Medical University
2011-2024
Fudan University
2010-2024
Inner Mongolia Medical University
2024
City University of Hong Kong, Shenzhen Research Institute
2019-2024
Army Medical University
2017-2024
Huashan Hospital
2010-2024
Second Affiliated Hospital of Jilin University
2017-2024
Beijing University of Chinese Medicine
2022-2024
Men who carry germline mutations in the BRCA2 gene have a higher risk of developing breast carcinoma than men general population. BRCA1 may also be at for carcinoma, but this association is not as well established. We evaluated risks male and mutation carriers US population based on data from 1939 families with 97 subjects that were collected eight centers across National Cancer Institute's Genetics Network. At all ages, cumulative cancer both noncarriers. The relative highest their 30s 40s...
Abstract Surface plasmon polaritons (SPPs) are extremely sensitive to the surrounding refractive index and have found important applications in ultrasensitive label‐free sensing. Reducing linewidth of an SPP mode is effective way improve figure merit (FOM) hence sensitivity plasmonic mode. Many efforts been devoted achieving a narrow by coupling, which inevitably results asymmetrical lineshape compromising performance. Instead, modes directly narrowed elaborately engineering periodic...
Despite the great success achieved by photoactivated chemotherapy, eradicating deep tumors using external sources with high tissue penetration depth remains a challenge. Here, we present cyaninplatin, paradigm of Pt(IV) anticancer prodrug that can be activated ultrasound in precise and spatiotemporally controllable manner. Upon sono-activation, mitochondria-accumulated cyaninplatin exhibits strengthened mitochondrial DNA damage cell killing efficiency, overcomes drug resistance as...
Insightful understanding of how interfacial structures and properties affect catalytic processes is one the most challenging issues in heterogeneous catalysis. Here, essential roles Pt–Au Pt−oxide−Au interfaces on activation H2 hydrogenation para-nitrothiophenol (pNTP) were studied at molecular level by situ surface-enhanced Raman spectroscopy (SERS) shell-isolated nanoparticle-enhanced (SHINERS). Pt–oxide–Au fabricated through synthesis Pt-on-Au Pt-on-SHINs nanocomposites. Direct...
The coronavirus disease 2019 (COVID-19) pandemic remains threatening to women and children, but clinical evidence regarding during pregnancy, puerperium lactation is limited. We assessed immunologic features of breastfeeding advice provided mother–infant pairs. This observational analysis was conducted in a tertiary-care centre Wuhan, China. Pregnant patients with laboratory-confirmed COVID-19 who delivered hospitalization were enrolled. Clinical characteristics serial specimens the pairs...
BackgroundDiesel exhaust particles (DEPs) are a major component of particulate matter in Europe's largest cities, and epidemiologic evidence links exposure with respiratory symptoms asthma exacerbations. Respiratory reflexes responsible for regulated by vagal afferent nerves, which innervate the airway. It is not known how DEP activates airway afferents to elicit symptoms, such as cough bronchospasm.ObjectiveWe sought identify mechanisms involved activation sensory DEPs.MethodsIn this study...
Abstract Adrenal cortex autoantibodies (ACA) were measured by immunofluorescence in 808 children with organ-specific autoimmune diseases without adrenal insufficiency. ACA found 14 (1.7%), mostly hypoparathyroidism (48%). Ten ACA-positive and 12 ACA-negative followed up for a maximum of 10 yr evaluation adrenocortical function (ACTH test) autoantibody status. In all patients steroid-producing cell assessed to steroid 21-hydroxylase, 17α-hydroxylase, cytochrome P450 side-chain cleavage enzyme...
In the Human Immunodeficiency Virus (HIV) Network for Prevention Trials (HIVNET) 012 trial in Uganda, 6-8 weeks after single-dose nevirapine (SD-NVP), NVP resistance mutations were detected at a higher rate women with HIV-1 subtype D than A. Here, we evaluate of C.NVP using ViroSeq Genotyping System.The portion any mutation was those C (45/65 [69.2%] and zidovudine trial, Malawi) HIVNET either A (28/144 [19.4%]; P<.0001) or (35/97 [36.1%]; P<.0001). multivariate model, (C vs. A: odds ratio...
Context: Patients with adrenal cortex autoantibodies (ACA) without overt autoimmune Addison’s disease (AAD) are at risk of failure. Design: To assess the contribution different clinical, immunological, genetic, and functional factors in progression to AAD, we followed up 100 ACA-positive 63 ACA-negative patients AAD for a maximum 21 yr (mean 6.0 yr, median 4.8). ACA were measured by immunofluorescence 21-OH (Abs) RIA. Adrenal function was assessed measuring basal levels cortisol,...
HIV-infected prisoners fare poorly after release. Though rarely available, opioid agonist therapy (OAT) may be one way to improve HIV and substance abuse treatment outcomes Of the 69 enrolled in a randomized controlled trial of directly administered antiretroviral therapy, 48 (70%) met DSM-IV criteria for dependence. these, 30 (62.5%) selected OAT, either as methadone (N = 7, 14.5%) or buprenorphine/naloxone (BPN/NLX; N 23, 48.0%). Twelve-week are reported sub-study those selecting BPN/NLX....
Objectives To determine the extent to which co‐occurrence of chronic obstructive pulmonary disease ( COPD ) and cognitive impairment affect adverse health outcomes in older adults. Design Multicenter longitudinal cohort study. Setting California, P ennsylvania, M aryland, N orth C arolina. Participants Three thousand ninety‐three community‐dwelling adults aged 65 from ardiovascular H ealth S tudy. Four hundred thirty‐one had at study baseline. Measurements Follow‐up began second CHS visit...
Abstract Surface‐enhanced Raman spectroscopy (SERS) is receiving increasing interests owing to its high sensitivity and molecular fingerprint information. The practical application of SERS relies on the highly enhancing, uniform, reproducible, affordable substrates. A novel gap‐free 3D substrate with unique hybrid plasmonic optical cavity (HPOC) structures improve uniformity reduce fabrication cost while maintaining enhancement introduced here. gold HPOC are fabricated by tunable holographic...
Platinum drugs are widely used in clinics to treat various types of cancer. However, a number severe side effects induced by the nonspecific binding platinum normal tissues limit their clinical use. The conversion platinum(II) into more inert platinum(IV) derivatives is promising strategy solve this problem. Some prodrugs, such as carboplatin-based tetracarboxylatoplatinum(IV) not easily reduced active species, leading low cytotoxicity vitro. In study, we report design and synthesis prodrug...
Abstract Although multitargeted Pt IV anticancer prodrugs have shown significant activities in reducing drug resistance, the types of bioactive ligands and drugs that can be conjugated to center remain limited O‐donors. Herein, we report synthesis complexes bearing axial pyridines via ligand exchange reactions. Unexpectedly, are quickly released after reduction, indicating their potential utilized as leaving groups. We further expand our synthetic approach obtaining two containing pyridinyl...
ABSTRACT Counts of Escherichia coli cells in water indicate the potential presence pathogenic microbes intestinal origin but give no indication sources microbial pollution. The objective this research was to evaluate methods for differentiating E. isolates livestock, wildlife, or human that might be used predict fecal pollution water. A collection 319 from feces cattle, poultry, swine, deer, goose, and moose, as well sewage, clinical samples three methods. One method...
Introduction: We used a sensitive point mutation assay, LigAmp, to detect and quantify K103N-containing variants in African women who received single-dose nevirapine (NVP) prevent mother-to-child HIV-1 transmission. Methods: Plasma for testing was collected 6 8 weeks postpartum from 301 (144 subtype A, 63 C, 94 D). Results: The portion of with 0.5% or more lowest A (60/144, 41.7%) highest C (44/63, 69.8%; P < 0.0001). K103N rarely detected pre-NVP samples. In multivariate model, detection...
ObjectiveWe assessed the impact of breastfeeding by women infected with human immunodeficiency virus (HIV)-1 on their morbidity and risk mortality children.Methods We analysed longitudinal data from two previous randomized clinical trials mother-to-child transmission HIV conducted between April 2000 March 2003 in Republic Malawi, Africa.Mothers HIV, newborns, were enrolled at time child's birth; they then returned for follow-up visits when child was aged 1 week, 6-8 weeks 3, 6, 9, 15, 18, 21...
Background. Pneumonia remains an important public health problem among elderly nursing home residents. This clinical trial sought to determine if a multicomponent intervention protocol, including manual tooth/gum brushing plus 0.12% chlorhexidine oral rinse, twice per day, upright positioning during feeding, could reduce the incidence of radiographically documented pneumonia residents, compared with usual care. Methods. cluster-randomized was conducted in 36 homes Connecticut. Eligible...
ABSTRACT We conducted a retrospective cohort study of patients with MRC grade II/III tuberculous meningitis (TBM) who accepted background antitubercular regimen (BR) or without linezolid (LZD). At the 4th week, LZD-BR group achieved faster and higher percentage Glasgow coma scale recovery temperature recovery, cerebrospinal fluid (CSF)/blood glucose ratio, lower CSF white blood cell counts than did BR group. Short-term supplementation may be more effective treatment for life-threatening TBM.