A5036744901- Exercise and Physiological Responses
- Immune cells in cancer
- Adipose Tissue and Metabolism
- Immune Cell Function and Interaction
- Influenza Virus Research Studies
- Tryptophan and brain disorders
- Muscle metabolism and nutrition
- Immunotherapy and Immune Responses
- Nutrition and Health in Aging
- Thermoregulation and physiological responses
- Frailty in Older Adults
- Neuroinflammation and Neurodegeneration Mechanisms
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Telomeres, Telomerase, and Senescence
- Diabetes and associated disorders
- Endometriosis Research and Treatment
- Genetics, Aging, and Longevity in Model Organisms
- Diet and metabolism studies
- Cytomegalovirus and herpesvirus research
- Viral Infections and Immunology Research
- Muscle Physiology and Disorders
- Resilience and Mental Health
- Long-Term Effects of COVID-19
- Cancer Immunotherapy and Biomarkers
UConn Health
2015-2024
University of Connecticut
2015-2024
Flatiron Health (United States)
2022
Universidad Cristiana Autónoma de Nicaragua
2022
The Ohio State University
2015-2016
Central Connecticut State University
2015
Charité - Universitätsmedizin Berlin
2007-2008
Franklin University
2007
Olgahospital
2003
Many successful ultra-endurance athletes have switched from a high-carbohydrate to low-carbohydrate diet, but they not previously been studied determine the extent of metabolic adaptations.Twenty elite ultra-marathoners and ironman distance triathletes performed maximal graded exercise test 180 min submaximal run at 64% VO2max on treadmill responses. One group habitually consumed traditional (HC: n=10, %carbohydrate:protein:fat=59:14:25) other (LC; 10:19:70) diet for an average 20 months...
Resilience, the ability to resist or recover from adverse effects of a stressor, is widespread interest in social, psychologic, biologic, and medical research particularly salient as capacity respond stressors becomes diminished with aging. To date, on human resilience responses factors influencing these has been limited.The National Institute Aging convened workshop August 2015 needs for improve measures predict assess Effects aging-related impairing homeostatic were developed examples...
Glioblastoma multiforme (GBM) is a highly lethal human cancer thought to originate from self-renewing and therapeutically-resistant population of glioblastoma stem cells (GSCs). The intrinsic mechanisms enacted by GSCs during 3D tumor formation, however, remain unclear, especially in the stages prior angiogenic/immunological infiltration. In this study, we performed deep characterization genetic, immune, metabolic profiles GBM organoids several patient-derived (GBMO). Despite being devoid...
Immunosenescence refers to age-related declines in the capacity respond infections such as influenza (flu). Caloric restriction represents a known strategy slow many aging processes, including those involving immune system. More recently, some changes microbiome have been described with aging, while gut appears influence responses flu vaccination and infection. With these considerations mind, we used well-established mouse model of infection explore impact infection, caloric on microbiome....
Peripheral nerve injuries account for roughly 3% of all trauma patients with over 900,000 repair procedures annually in the US. Of extremity peripheral injuries, 51% require a transected gap. The current gold-standard treatment autograft repair, has several shortcomings. Engineered constructs are currently only suitable short gaps or small diameter nerves. Here, we investigate novel guidance conduits aligned microchannel porosity that deliver sustained-release neurogenic 4-aminopyridine...
Abstract Clearance of senescent cells has demonstrated therapeutic potential in the context chronic age‐related diseases. Little is known, however, how clearing affects ability to respond an acute infection and form quality immunological memory. We aimed probe effects aged mice on immune response influenza (flu) infection. utilized a p16 trimodality reporter mouse model (p16‐3MR) allow for identification selective clearance p16‐expressing upon administration ganciclovir (GCV). While may...
Abstract Aging negatively impacts immunity, resulting in inefficient responses to vaccinations and infections. Fibroblastic reticular cells (FRCs) are the major stromal cell subset lymph nodes (LNs) play an intricate role orchestration control of adaptive immune responses. Although have a impact on responses, aging LN remains unclear. Quantitative analysis by flow cytometry revealed that there no significant differences number young aged at steady state but after influenza infection FRCs...
Aging and senescence impact CD4 T helper cell (Th) subset differentiation during influenza infection. In the lungs of infected aged mice, there were significantly greater percentages Th cells expressing transcription factor FoxP3, indicative regulatory (Treg), when compared to young. TGF-beta levels, which drive FoxP3 expression, also higher in bronchoalveolar lavage mice blocking reduced percentage FoxP3+ Since can be product senescent cells, these targeted by treatment with senolytic...
Although the influenza virus only infects respiratory system, myalgias are commonly experienced during infection. In addition to a greater risk of hospitalization and death, older adults more likely develop disability following infection; however, this relationship is understudied. We hypothesized that upon challenge with influenza, aging would be associated functional impairments, as well upregulation skeletal muscle inflammatory atrophy genes. Infected young aged mice demonstrated...
Abstract Background Aging is associated with progressive declines in immune responses leading to increased risk of severe infection and diminished vaccination responses. Influenza (flu) a killer older adults despite availability seasonal vaccines. Geroscience-guided interventions targeting biological aging could offer transformational approaches reverse broad aging. Here, we evaluated effects metformin, an FDA approved diabetes drug candidate anti-aging drug, on flu markers immunological...
Age is the greatest risk factor for adverse outcomes following influenza (flu) infection. The increased burden of senescent cells with age has been identified as a root cause in many diseases aging and targeting these drugs termed senolytics shown promise alleviating age-related declines across organ systems. However, there little known whether will improve deficits immune system. Here, we utilized well characterized senolytic treatment combination dasatinib quercetin (D + Q) to clear aged...
Background: Little is known about the prevalence of cellular senescence among immune cells (i.e., expressing markers, iSCs) nor there a gold-standard to efficiently measure iSCs. Major depressive disorder (MDD) in older adults has been associated with many hallmarks whole blood, leukocytes, and plasma, supporting strong connection between iSCs MDD. Here, we investigated phenotype Using single-cell phenotypic approach, circulating were examined for iSC biomarkers their relationship depression...