A5068331950- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Diet and metabolism studies
- Genetic Associations and Epidemiology
- Tryptophan and brain disorders
- Obsessive-Compulsive Spectrum Disorders
- Sleep and related disorders
- Bipolar Disorder and Treatment
- Forensic and Genetic Research
- Autism Spectrum Disorder Research
- Attention Deficit Hyperactivity Disorder
- Metabolomics and Mass Spectrometry Studies
- Cognitive Abilities and Testing
- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
- Schizophrenia research and treatment
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Treatment of Major Depression
- Genetics, Aging, and Longevity in Model Organisms
- Mental Health Research Topics
- Genomics and Rare Diseases
- Genetic Neurodegenerative Diseases
- Eating Disorders and Behaviors
- Immune Cell Function and Interaction
Centre for Addiction and Mental Health
2016-2025
University of Toronto
2016-2025
Central European Institute of Technology – Masaryk University
2024
École pour l'informatique et les nouvelles technologies
2024
Universidade Federal da Bahia
2023
Universidade Federal do Recôncavo da Bahia
2021
Mental Health Research Institute
2020
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2019
Anhembi Morumbi University
2016
Universidade Federal de Minas Gerais
2004-2013
Significance The EPIGEN Brazil Project is the largest Latin-American initiative to study genomic diversity of admixed populations and its effect on phenotypes. We studied 6,487 Brazilians from three population-based cohorts with different geographic demographic backgrounds. identified ancestry components these at a previously unmatched resolution. broadened our understanding African diaspora, principal destination which was Brazil, by revealing an component that likely derives slave trade...
Acquisition of detailed knowledge the structure and evolution Trypanosoma cruzi populations is essential for control Chagas disease. We profiled 75 strains parasite with five nuclear microsatellite loci, 24Salpha RNA genes, sequence polymorphisms in mitochondrial cytochrome oxidase subunit II gene. also used sequences available GenBank genes B NADH dehydrogenase 1. A multidimensional scaling plot (MDS) based data divided parasites into four clusters corresponding to T. I (MDS-cluster A), C),...
There has been intense debate over the immunological basis of schizophrenia, and potential utility adjunct immunotherapies. The major histocompatibility complex is consistently most powerful region association in genome-wide studies (GWASs) schizophrenia interpreted as strong genetic evidence supporting immune hypothesis. However, global pathway analyses provide inconsistent involvement it remains unclear whether data support an etiology per se. Here we empirically test hypothesis that...
<i>Background/Aims:</i> Approximately four million Africans were taken as slaves to Brazil, where they interbred extensively with Amerindians and Europeans. We have previously shown that while most White Brazilians carry Y chromosomes of European origin, display high proportions African Amerindian mtDNA lineages, because sex-biased genetic admixture. <i>Methods:</i> studied the chromosome haplogroup structure 120 Black males from Sao Paulo, Brazil....
There is a consensus that modern humans arrived in the Americas 15,000-20,000 y ago during Late Pleistocene, most probably from northeast Asia through Beringia. However, there still debate about time of entry and number migratory waves, including apparent inconsistencies between genetic morphological data on Paleoamericans. Here we report identification mitochondrial sequences belonging to haplogroups characteristic Polynesians DNA extracted ancient skulls now extinct Botocudo Indians...
The pace of biological aging varies between people independently chronological age and mitochondria dysfunction is a key hallmark aging. We hypothesized that higher functional impact (FI) score mitochondrial DNA (mtDNA) variants might contribute to premature tested the relationships novel FI mtDNA epigenetic in young adulthood. A total 81 participants from European Longitudinal Study Pregnancy Childhood (ELSPAC) prenatal birth cohort had good quality genetic data as well blood-based markers...
<title>Abstract</title> Obsessive-compulsive disorder (OCD) is a severe neuropsychiatric with clear evidence of genetic vulnerability, although specific risk factors are not fully understood. Mitochondrial dysfunction has been implicated in other disorders, particularly through its role oxidative stress, and thus merits exploration OCD. Here we first examined the association set 59 mitochondrial single nucleotide polymorphisms (SNPs) OCD symptom severity. These SNPs located inside 28...
For T3 to mediate its biological effects, the prohormone T4 must be activated by removal of an outer-ring iodine type 1 or 2 deiodinases (D1 and D2) with approximately 60% daily production in rodents being produced extrathyroidally through this pathway. To further define role these enzymes thyroid hormone homeostasis, we backcrossed targeted disruption Dio2 gene into C3H/HeJ (C3H) mice genetically low D1 expression create C3H-D2KO mouse. Remarkably, maintain euthyroid serum levels normal...