A5060455962- Genetic Associations and Epidemiology
- Tryptophan and brain disorders
- Pharmacogenetics and Drug Metabolism
- Diabetes and associated disorders
- Schizophrenia research and treatment
- Mitochondrial Function and Pathology
- Muscle Physiology and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Bioinformatics and Genomic Networks
- HIV Research and Treatment
- Inflammatory Myopathies and Dermatomyositis
- Glycogen Storage Diseases and Myoclonus
- Genetic Neurodegenerative Diseases
- Receptor Mechanisms and Signaling
- Systemic Lupus Erythematosus Research
- Child and Adolescent Psychosocial and Emotional Development
- Parkinson's Disease and Spinal Disorders
- Amyotrophic Lateral Sclerosis Research
- Adolescent and Pediatric Healthcare
- Myasthenia Gravis and Thymoma
- Metabolism and Genetic Disorders
- Smoking Behavior and Cessation
- Parathyroid Disorders and Treatments
- Mental Health Research Topics
- Complement system in diseases
Centre for Addiction and Mental Health
2015-2024
University of Toronto
2015-2024
Mental Health Research Canada
2023
Canada Research Chairs
2016-2023
Hôpital de la Timone
1995-2017
Harvard University
2015-2016
Brigham and Women's Hospital
2015-2016
University of New Brunswick
2016
University of Guelph
2013
Western University
2012
C-reactive protein (CRP) is associated with immune, cardiometabolic, and psychiatric traits diseases. Yet it inconclusive whether these associations are causal.We performed Mendelian randomization (MR) analyses using two genetic risk scores (GRSs) as instrumental variables (IVs). The first GRS consisted of four single nucleotide polymorphisms (SNPs) in the CRP gene (GRSCRP), second 18 SNPs that were significantly levels largest genome-wide association study (GWAS) to date (GRSGWAS). To...
Abstract Many immune diseases occur at different rates among people with schizophrenia compared to the general population. Here, we evaluated whether this phenomenon might be explained by shared genetic risk factors. We used data from large genome-wide association studies compare architecture of 19 diseases. First, 581 variants previously reported associated significance. identified five potentially pleiotropic effects. While colocalization analyses were inconclusive, functional...
Abstract Objectives We assessed the current genetic evidence for involvement of various cell types and tissue in etiology neurodegenerative diseases, especially relation to neuroinflammatory hypothesis diseases. Methods obtained large‐scale genome‐wide association study ( GWAS ) summary statistics from Parkinson's disease PD ), Alzheimer's AD amyotrophic lateral sclerosis ALS ). used multiple MS an autoimmune central nervous system, as a positive control. applied stratified LD score...
Antipsychotic medications are the gold-standard treatment for schizophrenia, and often prescribed other mental conditions. However, efficacy side-effect profiles of these drugs heterogeneous, with large interindividual variability. As a result, selection remains largely trial-and-error process, many failed regimens endured before finding tolerable balance between symptom management side effects. Much variability in response effects is due to genetic factors (heritability, h2~ 0.60-0.80)....
There has been intense debate over the immunological basis of schizophrenia, and potential utility adjunct immunotherapies. The major histocompatibility complex is consistently most powerful region association in genome-wide studies (GWASs) schizophrenia interpreted as strong genetic evidence supporting immune hypothesis. However, global pathway analyses provide inconsistent involvement it remains unclear whether data support an etiology per se. Here we empirically test hypothesis that...
Abstract Background Family history is a long-standing and readily obtainable risk factor for schizophrenia (SCZ). Low-cost genotyping technologies have enabled large genetic studies of SCZ, the results suggest utility scores (GRS, direct assessments inherited common variant risk). Few evaluated family GRS simultaneously to ask whether one can explain away other. Methods We studied 5959 SCZ cases 8717 controls from four Nordic countries. All subjects had data national registers genome-wide...
Mutations in various genes of the neuromuscular junction cause congenital myasthenic syndrome (CMS). A single truncating mutation (epsilon1293insG) acetylcholine receptor epsilon subunit gene (CHRNE) was most often identified CMS families originating from North Africa and possibly a founder mutation.Twenty-three were studied with an early onset form Tunisia, Algeria, Morocco, Libya. Screening for epsilon1293insG performed by direct sequencing. Haplotype analysis done 9 (CA)n repeat...
ABSTRACT bla SHV genes from Escherichia coli and Salmonella enterica isolates chicken ( n = 19) pork 1) were identified as SHV-2 5) or SHV-2a 15). Eighteen on plasmids of the incI1 15), incP 2), incFIB incompatibility groups. These all transferable by conjugation between E. S. .
The Nicotine Metabolite Ratio (NMR; 3‐hydroxycotinine/cotinine), a highly heritable index of nicotine metabolic inactivation by the CYP2A6 enzyme, is associated with numerous smoking behaviors and diseases, as well unique cessation outcomes. However, NMR cannot be measured in nonsmokers, former smokers, or intermittent for example, evaluating tobacco‐related disease risk. Traditional pharmacogenetic groupings based on * alleles capture modest portion variation. We previously created weighted...
A positive correlation between antipsychotic-induced weight gain (AIWG) and the antagonist effect of antipsychotic drugs at histamine H1 receptor (HRH1) as well agonist H3 (HRH3) in brain has been consistently demonstrated. We investigated potential impact single-nucleotide polymorphisms (SNPs) HRH1 HRH3 genes on AIWG.We analysed 40 tagSNPs (n = 34) 6) schizophrenia/schizoaffective disorder patients 193) primarily treated with clozapine or olanzapine for up to 14 weeks. Linear regression was...