A5025773189- Schizophrenia research and treatment
- Pharmacogenetics and Drug Metabolism
- Venous Thromboembolism Diagnosis and Management
- Plant-based Medicinal Research
- Ubiquitin and proteasome pathways
- Histone Deacetylase Inhibitors Research
- Identity, Memory, and Therapy
- Regulation of Appetite and Obesity
- Drug-Induced Hepatotoxicity and Protection
- Impact of Technology on Adolescents
- Pancreatic function and diabetes
- Bipolar Disorder and Treatment
- Genomics and Chromatin Dynamics
- Genetic Associations and Epidemiology
- Diet and metabolism studies
- Cognitive Abilities and Testing
- Poisoning and overdose treatments
- Acute Ischemic Stroke Management
- Diabetes Treatment and Management
- Traumatic Brain Injury and Neurovascular Disturbances
University of Calgary
2017-2018
Centre for Addiction and Mental Health
2014-2015
Toronto Metropolitan University
2013-2014
Antipsychotic medications are the gold-standard treatment for schizophrenia, and often prescribed other mental conditions. However, efficacy side-effect profiles of these drugs heterogeneous, with large interindividual variability. As a result, selection remains largely trial-and-error process, many failed regimens endured before finding tolerable balance between symptom management side effects. Much variability in response effects is due to genetic factors (heritability, h2~ 0.60-0.80)....
Rtt109 is a fungal histone acetyltransferase (HAT) that catalyzes H3 acetylation functionally associated with chromatin assembly. Rtt109-mediated involves two chaperones, Asf1 and Vps75. In vivo, requires both chaperones for lysine 9 (H3K9ac) but only full H3K56ac. vitro, Rtt109-Vps75 H3K9ac H3K56ac, whereas Rtt109-Asf1 this study, we extend the in vitro chaperone-associated substrate specificity of by showing it acetylates vertebrate linker presence Vps75 not Asf1. addition, demonstrate...
Background and purposeAntipsychotics (APs) are the primary method of treatment for schizophrenia other psychotic disorders. Unfortunately, lengthy trial-and-error approaches typically required to find optimal medication dosage due a large interindividual variability with outcome AP treatment. The literature has shown abundant evidence genetic component in individuals' responses APs. Pharmacogenetic studies analyze specific markers their association symptom improvement occurrence side effects...
Black henbane (Hyoscyamus niger) is a member of the nightshade family and an invasive species that grows world-wide, including in Canada. toxic due to its tropane alkaloid contents: hyoscyamine, scopolamine (hyoscine), atropine. We present two cases unintentional, acute poisoning. A 65-year-old woman her 71-year-old husband presented emergency department with tachycardia, confusion, hallucinations, urinary retention after eating plant thought be parsnip from their garden, later identified by...