A5065284992- Telomeres, Telomerase, and Senescence
- Cutaneous Melanoma Detection and Management
- Nonmelanoma Skin Cancer Studies
- Developmental Biology and Gene Regulation
- Electrospun Nanofibers in Biomedical Applications
- Birth, Development, and Health
- Genetics, Aging, and Longevity in Model Organisms
- Single-cell and spatial transcriptomics
- Immune cells in cancer
- Neurobiology and Insect Physiology Research
- Cystic Fibrosis Research Advances
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiomyopathy and Myosin Studies
- Psychology of Moral and Emotional Judgment
- 3D Printing in Biomedical Research
- Tracheal and airway disorders
- Hemostasis and retained surgical items
- Advanced Fluorescence Microscopy Techniques
- Xenotransplantation and immune response
- Misinformation and Its Impacts
- Skin Protection and Aging
- Periodontal Regeneration and Treatments
- Surgical Sutures and Adhesives
- Corneal Surgery and Treatments
- Mesenchymal stem cell research
University of Connecticut
2021-2025
UConn Health
2018-2024
University of Vermont
2016-2021
University of Canterbury
2020
Emory University
2020
University of Toronto
2020
Hydrogels with or without chemical cross-linking have been studied and used for biomedical applications, such as tissue repair, surgical sealants, three dimensional biofabrication. These materials often undergo a physical sol–gel gel–sol transition between room body temperatures can also be chemically cross-linked at these to give stability. However, few studies clearly shown the effect of heating/cooling rates on transitions. Moreover, only little is known about temperature state modulus...
Abstract Aging is one of the major risk factors for degenerative joint disorders, including those involving temporomandibular (TMJ). TMJ degeneration occurs primarily in population over 65, significantly increasing discomfort, restricted mobility, and reduced quality life. Unfortunately, there currently no effective mechanism‐based treatment available clinic to alleviate with aging. We now demonstrate that intermittent administration senolytics, drugs which can selectively clear senescent...
Stem-cell niche signaling is short-range in nature, such that only stem cells but not their differentiating progeny receive self-renewing signals. At the apical tip of Drosophila testis, 8 to 10 germline (GSCs) surround hub, a cluster somatic organize stem-cell niche. We have previously shown GSCs form microtubule-based nanotubes (MT-nanotubes) project into hub cells, serving as platform for signal reception; this spatial arrangement ensures reception specifically by cells. The receptor...
Flightin is a myosin binding protein present in Pancrustacea. In Drosophila, flightin expressed the indirect flight muscles (IFM), where it required for flexural rigidity, structural integrity, and length determination of thick filaments. Comparison sequences from multiple Drosophila species revealed tripartite organization indicative three functional domains subject to different evolutionary constraints. We use atomic force microscopy investigate roles N-terminal domain C-terminal that show...
Abstract Obesity remains a major factor for diabetes associated with insulin resistance and increases the risk of neuropsychiatric disorders, such as anxiety, depression, cognitive deficits, resulting in shortened lifespan healthspan. Cellular senescence, state permanent cell-cycle arrest, has been recognized an important biological process underlying obesity obesity-associated neurological disorders. My project aims to alleviate metabolic dysfunction by targeting p21Cip1-highly-expressing...
Abstract Stem-cell niche signaling is short-range in nature, such that only stem cells but not their differentiating progeny experience self-renewing signals. At the apical tip of Drosophila testes, 8 to 10 germline (GSCs) surround hub, a cluster somatic function as major component cell niche. We have shown GSCs form microtubule-based nanotubes (MT-nanotubes), which project into hub cells, serving platform for signal reception: receptor Tkv expressed by localizes surface MT-nanotubes, where...