A5007962039- Mesenchymal stem cell research
- Neonatal Respiratory Health Research
- Tissue Engineering and Regenerative Medicine
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Congenital Diaphragmatic Hernia Studies
- Transplantation: Methods and Outcomes
- Tracheal and airway disorders
- Electrospun Nanofibers in Biomedical Applications
- Proteoglycans and glycosaminoglycans research
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Medical Imaging and Pathology Studies
- Extracellular vesicles in disease
- Asthma and respiratory diseases
- Inhalation and Respiratory Drug Delivery
- MicroRNA in disease regulation
- Allergic Rhinitis and Sensitization
- Macrophage Migration Inhibitory Factor
- Circular RNAs in diseases
- Cancer Cells and Metastasis
- Peptidase Inhibition and Analysis
- Wound Healing and Treatments
- Long-Term Effects of COVID-19
- Medical Imaging Techniques and Applications
- Apelin-related biomedical research
Lund University
2016-2025
University of Vermont
2018-2025
Lung Institute
2014-2016
Abstract Mesenchymal stromal cells (MSC) are multipotent with regenerative and immune-modulatory properties. Therefore, MSC have been proposed as a potential cell-therapy for bronchiolitis obliterans syndrome (BOS). On the other hand, there publications demonstrating that might be involved in development of BOS. Despite limited knowledge regarding functional role tissue-resident lung-MSC, several clinical trials performed using MSC, particularly bone marrow (BM)-derived various lung...
Mesenchymal stromal (stem) cells (MSCs) are increasingly demonstrated to ameliorate experimentally induced lung injuries through disease-specific anti-inflammatory actions, thus suggesting that different in vivo inflammatory environments can influence MSC actions. To determine the effects of representative conditions, human bone marrow-derived MSCs (hMSCs) were exposed vitro culture conditions from bronchoalveolar lavage fluid (BALF) samples obtained patients with either acute respiratory...
Mesenchymal stem cells (MSC) have not only been implicated in the development of lung diseases, but they also proposed as a future cell-based therapy for diseases. However, cellular identity primary MSC human tissues has yet reported. This study therefore aimed to identify and characterise 'bona fide' lungs investigate if numbers correlate with bronchiolitis obliterans syndrome lung-transplanted patients.Primary were directly isolated or culture-derived from central peripheral transbronchial...
Background Despite increased interest in mesenchymal stromal cell (MSC)-based therapies for acute respiratory distress syndrome (ARDS), clinical investigations have not yet been successful and our understanding of the potential vivo mechanisms MSC actions ARDS remains limited. is driven by an severe innate immune dysregulation, often characterised inflammation, coagulation injury. How this inflammatory microenvironment influences functions to be determined. Aim The aim study was...
Mesenchymal stromal cells (MSC) are ideal candidates for cell therapies, due to their immune-regulatory and regenerative properties. We have previously reported that lung-derived MSC tissue-resident with lung-specific properties compared bone marrow-derived MSC. Assessing relevant molecular differences between lung-MSC marrow-MSC is important, given such may impact behavior potential therapeutic use. Here, we present an in-depth mass spectrometry (MS) based strategy investigate the proteomes...
Growing evidence demonstrates that human mesenchymal stromal cells (MSCs) modify their in vivo anti-inflammatory actions depending on the specific inflammatory environment encountered. Understanding this better is crucial to refine MSC-based cell therapies for lung and other diseases. Using acute exacerbations of cystic fibrosis (CF) disease as a model, effects ex MSC exposure clinical bronchoalveolar lavage fluid (BALF) samples, surrogate environment, viability, gene expression, secreted...
During wound healing processes fibroblasts account for closure by adopting a contractile phenotype. One disease manifestation of COPD is emphysema which characterized destruction alveolar walls and our hypothesis that in the lungs differentiate into more phenotype as response to deteriorating environment. Bronchial (central) parenchymal (distal) were isolated from lung explants patients (n = 9) (GOLD stage IV) biopsies control subjects donor 12). Tissue-derived assessed expression proteins...
Mesenchymal cells are important components of specified niches in the lung, and can mediate a wide range processes including tissue regeneration repair. Dysregulation these lead to improper remodeling as observed several lung diseases. The mesenchymal responsible remain poorly described, partially due heterogenic nature compartment absence appropriate markers. Here, we describe that CD105+CD90+ be divided into two populations based on their expression CD13/aminopeptidase N (CD105+CD90+CD13-...
Abstract Purpose of Review Mesenchymal stromal cell (MSC)–based therapies provide a platform for new therapeutic strategies in lung diseases. This review provides an overview the current status field, along with some challenges ahead including better understanding MSC actions different diseases, personalized approaches to select patients most likely benefit, and growing problem stem tourism. Recent Findings A newly evolving concept suggests that MSCs shape their immunomodulatory depending on...
Mesenchymal stromal cell (MSC)-based therapies for inflammatory diseases rely mainly on the paracrine ability to modulate activity of macrophages. Despite recent advances, there is scarce information regarding changes secretome content attributed physiomimetic cultures and, especially, how influence macrophage therapy. hLMSCs from human donors were cultured devices developed in house that enabled lung-mimetic strain. hLMSC was analyzed typical cytokines, chemokines and growth factors. RNA...
In this review, the Basic and Translational Science Assembly of European Respiratory Society provides an overview 2022 International Congress highlights. We discuss consequences respiratory events from birth until old age regarding climate change related alterations in air quality due to pollution caused by increased ozone, pollen, wildfires fuel combustion as well increasing presence microplastic microfibres. Early life such effect hyperoxia context bronchopulmonary dysplasia crucial...
Diabetes mellitus type 1 (T1D) has numerous complications including autonomic neuropathy, i.e. dysfunction of the autonomous nervous system. This study focuses on Heat Shock Protein 27 (HSP27), Macrophage Migration Inhibitory Factor (MIF), Plasminogen Activator Inhibitor-1 (PAI-1) and HbA1c their possible roles in effects diabetes system.Patients with T1D (n = 32, 41% women) were recruited 1985 followed up four occasions (1989, 1993, 1998, 2005). Autonomic function was tested using...