A5078931254- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Advanced Chemical Sensor Technologies
- Air Quality and Health Impacts
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Antioxidant Activity and Oxidative Stress
- Nanoparticles: synthesis and applications
- Phytochemicals and Antioxidant Activities
- Occupational exposure and asthma
- Occupational and environmental lung diseases
- Sarcoidosis and Beryllium Toxicity Research
- Neonatal Respiratory Health Research
- Free Radicals and Antioxidants
- Inhalation and Respiratory Drug Delivery
- Genomics, phytochemicals, and oxidative stress
- Pulmonary Hypertension Research and Treatments
- Carcinogens and Genotoxicity Assessment
- Advanced Glycation End Products research
- Respiratory and Cough-Related Research
- Vitamin C and Antioxidants Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Asthma and respiratory diseases
- Congenital Diaphragmatic Hernia Studies
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Olfactory and Sensory Function Studies
Maastricht University
2016-2025
Leibniz Institute of Environmental Medicine
2012-2017
University Medical Center
2015
Maastricht University Medical Centre
2008-2015
Heinrich Heine University Düsseldorf
2010-2013
University of Vermont
2009
The SARS-CoV-2 pandemic affecting the human respiratory system severely challenges public health and urgently demands for increasing our understanding of COVID-19 pathogenesis, especially host factors facilitating virus infection replication. was reported to enter cells via binding ACE2, followed by its priming TMPRSS2. Here, we investigate ACE2 TMPRSS2 expression levels their distribution across cell types in lung tissue (twelve donors, 39,778 cells) derived from subsegmental bronchial...
Breath tests cover the fraction of nitric oxide in expired gas (FeNO), volatile organic compounds (VOCs), variables exhaled breath condensate (EBC) and other measurements. For EBC for FeNO, official recommendations standardised procedures are more than 10 years old there is none VOCs particles. The aim this document to provide technical standards sample collection analytic approaches highlight future research priorities field. new developments advances technology have been evaluated current...
The use of engineered nanoparticles in the food sector is anticipated to increase dramatically, whereas their potential hazards for gastrointestinal tract are still largely unknown. We investigated cytotoxic and DNA-damaging effects several types fine particles relevant as additives (TiO2 SiO2) or packaging (ZnO MgO) well carbon black on human intestinal Caco-2 cells. All particles, except MgO, were (LDH WST-1 assay). ZnO, lesser extent SiO2, induced significant DNA damage (Fpg-comet), while...
Titanium dioxide has a long-standing use as food additive. Micrometric powders are, e.g., applied whiteners in confectionary or dairy products. Possible hazards of ingested nanometric TiO(2) particles for humans and the potential influence varying specific surface area (SSA) are currently under discussion. Five TiO(2)-samples were analyzed purity, crystallinity, primary particle size, SSA, ζ potential, aggregation/agglomeration. Their to induce cytotoxicity, oxidative stress, DNA damage was...
Ventilator-associated pneumonia (VAP) is a nosocomial infection occurring in the intensive care unit (ICU). The diagnostic standard based on clinical criteria and bronchoalveolar lavage (BAL). Exhaled breath analysis promising non-invasive method for rapid diagnosis of diseases contains volatile organic compounds (VOCs) that can differentiate diseased from healthy individuals. aim this study was to determine whether VOCs exhaled be used as monitoring tool VAP. One hundred critically ill...
The identification of specific volatile organic compounds (VOCs) produced by microorganisms may assist in developing a fast and accurate methodology for the determination pulmonary bacterial infections exhaled air. As first step, bacteria were cultured their headspace analyzed total amount excreted VOCs to select those which are exclusively associated with microorganisms. Development rapid, noninvasive species improve diagnostics antibiotic therapy, ultimately leading controlling resistance...
Increasing evidence from toxicological and epidemiological studies indicates that the central nervous system is an important target for ambient air pollutants. We have investigated whether long-term inhalation exposure to diesel engine exhaust (DEE), a dominant contributor particulate pollution in urban environments, can aggravate Alzheimer's Disease (AD)-like effects female 5X Familial AD (5XFAD) mice their wild-type littermates. Following 3 13 weeks exposures diluted DEE (0.95 mg/m3, 6...
Novel aspects of engineered nanoparticles offer many advantages for optimising food products and packaging. However, their potential hazards in the gastrointestinal tract require further investigation. We evaluated toxic inflammatory two types particles that might become increasingly relevant to industry, namely SiO2 ZnO. The materials were characterised morphology, oxidant generation hydrodynamic behaviour. Cytotoxicity interleukin-8 mRNA protein expression human intestinal Caco-2 cells....
Activation of the NADPH oxidase homolog dual 1 (DUOX1) within airway epithelium represents a key mechanism innate host defense, through enhanced production H2O2, which mediates cellular signaling pathways that regulate various inflammatory mediators. Production CXC chemokine interleukin (IL)-8/CXCL8 forms common epithelial response to many diverse stimuli, including bacterial and viral triggers, environmental oxidants, other biological mediators, suggesting potential involvement pathway may...
Idiopathic pulmonary fibrosis (IPF) is characterized by a disturbed redox balance associated with inflammation. To restore this balance, antioxidants are often suggested as therapy for IPF but previous clinical trials these compounds and their precursors have not been successful in the clinic. The exogenous antioxidant quercetin, which has versatile profile effective restoring might be better candidate. aim of study was to evaluate protective effect quercetin on oxidative inflammatory...
SUMMARY The SARS-CoV-2 pandemic affecting the human respiratory system severely challenges public health and urgently demands for increasing our understanding of COVID-19 pathogenesis, especially host factors facilitating virus infection replication. was reported to enter cells via binding ACE2, followed by its priming TMPRSS2. Here, we investigate ACE2 TMPRSS2 expression levels their distribution across cell types in lung tissue (twelve donors, 39,778 cells) derived from subsegmental...
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a chronic, lethal disease of which the etiology still not fully understood. Current treatment comprises two FDA-approved drugs that can slow down yet stop or reverse disease. As IPF pathology associated with an altered redox balance, adding modulating component to current therapy might exert beneficial effects. Quercetin dietary antioxidant strong capacities suggested part its antioxidative effects via activation redox-sensitive...