A5033914815- Heart Failure Treatment and Management
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Biomedical Text Mining and Ontologies
- Antiplatelet Therapy and Cardiovascular Diseases
- Retinal Diseases and Treatments
- Potassium and Related Disorders
- Pharmaceutical Practices and Patient Outcomes
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Chronic Disease Management Strategies
- Peripheral Artery Disease Management
- Retinal Imaging and Analysis
- Cardiac Imaging and Diagnostics
- Medication Adherence and Compliance
- Diabetes Management and Education
- Data Quality and Management
- Retinal and Optic Conditions
- Diabetes Management and Research
- Cardiac electrophysiology and arrhythmias
- Acute Kidney Injury Research
- Ethics in Clinical Research
- Electrolyte and hormonal disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
Clinical Research Institute
2012-2024
Duke University
2012-2022
Duke Medical Center
2014-2016
Sophia Genetics (Switzerland)
2015
Mayo Clinic
2014
VA Palo Alto Health Care System
2014
University of California, Los Angeles
2014
University of Colorado Anschutz Medical Campus
2014
University of Colorado Denver
2014
Yale University
2014
Introduction: Distributed research networks (DRNs) are critical components of the strategic roadmaps for National Institutes Health and Food Drug Administration as they work to move toward large-scale systems evidence generation. The Patient-Centered Clinical Research Network (PCORnet®) is one first DRNs incorporate electronic health record data from multiple domains on a national scale. Before conducting analyses in DRN, it important assess quality characteristics data.Methods: PCORnet’s...
<h3>Importance</h3> The benefits of cardiac resynchronization therapy (CRT) in clinical trials were greater among patients with left bundle-branch block (LBBB) or longer QRS duration. <h3>Objective</h3> To measure associations between duration and morphology outcomes receiving a CRT defibrillator (CRT-D) practice. <h3>Design, Setting, Participants</h3> Retrospective cohort study Medicare beneficiaries the National Cardiovascular Data Registry's ICD Registry 2006 2009 who underwent CRT-D...
Background A subset of patients hospitalized with acute heart failure experiences worsening clinical status and requires escalation therapy. Worsening is an end point in many trials, but little known about its prevalence practice associated outcomes. Methods Results We analyzed inpatient data from the Acute Decompensated Heart Failure National Registry linked to Medicare claims examine outcomes failure, defined as need for therapy at least 12 hours after hospital presentation. compared...
A 2008 expert consensus statement outlined the minimum frequency of follow-up patients with cardiovascular implantable electronic devices (CIEDs).We studied 38 055 Medicare beneficiaries who received a new CIED between January 1, 2005, and June 30, 2009. The main outcome measure was variation by patient factors year device implantation. We determined number were eligible for attended an in-person visit within 2 to 12 weeks, 0 16 1 after Among patients, 42.4% had initial weeks. This...
For end-stage liver disease (ESLD) patients, care focuses on managing the life-threatening complications of portal hypertension, causing high resource utilization.To describe end-of-life trajectory hospitalized ESLD patients in Medicare.Using a 5% random sample Medicare fee-for-service beneficiaries, we performed retrospective cohort study, identifying and heart failure (HF) (2007-2011). Index hospitalization end points included mortality, discharge to hospice, length stay. Postdischarge...
Catheter ablation of atrial fibrillation (AF) has become an increasingly safe and effective therapy. This been partly attributed to the use adjunctive imaging modalities. We aimed describe associated outcomes periprocedural for AF ablation.We studied all Medicare fee-for-service claims from July 2007 December 2009, identified studies before during ablation, including transoesophageal echocardiography (TEE), intracardiac (ICE), CT MRI. The primary were death, stroke or transient ischaemic...
Cardiac resynchronization therapy with defibrillator (CRT-D) reduces morbidity and mortality among selected patients heart failure in clinical trials. The effectiveness of this practice has not been well studied.We compared a cohort 4471 from the National Cardiovascular Data Registry's Implantable Cardioverter-Defibrillator (ICD) Registry hospitalized primarily for who received CRT-D between April 1, 2006, December 31, 2009, to historical control 4888 without Acute Decompensated Heart...
To examine associations between newly diagnosed neovascular age-related macular degeneration and direct medical costs.This retrospective observational study matched 23,133 Medicare beneficiaries with 2004 2008 a control group of 92,532 on the basis age, sex, race. The index date for each case-control set corresponded to first diagnosis case. Main outcome measures were total costs per patient degeneration-related case 1 year before after date.Mean cost in was $12,422, $4,884 higher than...
Background: Medicare is the single largest purchaser of laboratory testing in United States, yet test results associated with claims have historically not been available. Objective: The purpose this study was to describe both linkage data and completeness these data. In a subgroup beneficiaries initiating angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers, we also demonstrate generalizability values compared those without values. We end discussion limitations...
To access the accuracy of Logical Observation Identifiers Names and Codes (LOINC) mapping to local laboratory test codes that is crucial data integration across time healthcare systems.We used software tools manual reviews estimate rate LOINC errors among 179 million mapped results from 2 DataMarts in PCORnet. We separately reported unweighted weighted error rates, overall by parts term.Of included 537 986 for 3029 quantitative tests, 95.4% were correctly implying an 4.6% rate. Error rates...
Self-reported health data are used by insurance companies to assess risk. Most studies show underreporting compared with clinical measurements.To compare self-reported height, weight, blood pressure, waist circumference, and dietary intake registered dietitian's (RD's) measures of the same parameters.This is a secondary analysis collected in larger study on benefits Medical Nutrition Therapy from an RD for overweight obese patients when provided free charge through benefit.Participants...
Background— Patients with heart failure and atrial fibrillation are at higher risk of thromboembolic events than patients alone. Yet, the use anticoagulation therapy varies in clinical practice, especially among older patients, for whom its effectiveness is poorly understood. Methods Results— Using registry data linked to Medicare claims from 2005 2011, we examined outcomes hospitalized who newly initiated discharge. We used Cox proportional hazards models inverse probability-weighted...