A5089852698- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Retinal Development and Disorders
- Ocular and Laser Science Research
- Photoreceptor and optogenetics research
- Ocular Diseases and Behçet’s Syndrome
- Optical Coherence Tomography Applications
- Intraocular Surgery and Lenses
- Cerebral Venous Sinus Thrombosis
- Neonatal and fetal brain pathology
- Dermatologic Treatments and Research
- Neuroscience and Neuropharmacology Research
- Corneal surgery and disorders
- Ocular Infections and Treatments
- Connexins and lens biology
- Neuroscience and Neural Engineering
- Ophthalmology and Visual Impairment Studies
- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Neuroscience of respiration and sleep
- Advanced Memory and Neural Computing
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Ocular and Foreign Body Injuries
Hospital de Clínicas de Porto Alegre
2013-2024
Universidade Federal do Rio Grande do Sul
2015-2024
University of Rio Grande and Rio Grande Community College
2023
Universidade Federal do Rio Grande
2020
Stanford University
2012-2014
Universidade Federal de São Paulo
2006-2013
Instituto da Visão
2007-2011
Universidade de São Paulo
2009
Fundação de Apoio à Universidade Federal de São Paulo
2008
University of California, Irvine
2004
Purpose.: To compare modified Early Treatment Diabetic Retinopathy Study (mETDRS) focal/grid laser photocoagulation with normal-density (ND-SDM) or high-density (HD-SDM) subthreshold diode-laser micropulse for the treatment diabetic macular edema (DME). Methods.: A prospective, randomized, controlled, double-masked clinical trial patients previously untreated DME and best corrected visual acuity (BCVA) worse than 20/40 better 20/400. Patients were randomized to receive either mETDRS (42...
The objective of this work is to develop and test a photovoltaic retinal prosthesis for restoring sight patients blinded by degenerative diseases. A silicon photodiode array subretinal stimulation has been fabricated silicon-integrated-circuit/MEMS process. Each pixel in the two-dimensional contains three series-connected photodiodes, which photovoltaically convert pulsed near-infrared light into bi-phasic current stimulate nearby neurons without wired power connections. device thickness...
Laser therapy for diabetic macular edema and other retinal diseases has been used within a wide range of laser settings: from intense burns to nondamaging exposures. However, there no algorithm dosimetry that could determine parameters yielding predictable extent tissue damage. This multimodal imaging structural correlation study aimed verify calibrate computational model-based titration ranging coagulative effects.Endpoint Management, an based on model photothermal damage, was set various...
Purpose: Retinal photocoagulation and nondamaging laser therapy are used for treatment of macular disorders, without understanding the response mechanism with no rationale dosimetry. To establish a proper titration algorithm, we measured range tissue damage threshold. We then evaluated safety efficacy retinal (NRT) based on this algorithm chronic central serous chorioretinopathy (CSCR) telangiectasia (MacTel). Methods: to below threshold was assessed in pigmented rabbits by expression heat...
BACKGROUND AND OBJECTIVE: To evaluate 810-nm subthreshold diode micropulse (SDM) laser in patients with chronic central serous chorioretinopathy (CSC). PATIENTS METHODS: Prospective, randomized, double-blind, sham-controlled pilot trial. Patients were randomized to SDM treatment (group 1) or sham procedure 2). Primary outcome measure was change best corrected visual acuity (BCVA); secondary macular thickness after 3 months. Laser performed along the detached area. At 3-month visit, all...
CNS neurons change their connectivity to accommodate a changing environment, form memories, or respond injury. Plasticity in the adult mammalian retina after injury disease was thought be limited restructuring resulting abnormal retinal anatomy and function. Here we report that restore normal function Patches of photoreceptors rabbit were destroyed by selective laser photocoagulation, leaving inner (bipolar, amacrine, horizontal, ganglion cells) intact. Photoreceptors located outside damaged...
To assess safety and clinical efficacy of the nondamaging photothermal therapy for macula treatment chronic central serous retinopathy.Sixteen eyes 16 patients with persistent retinopathy (>4 months duration) were treated PASCAL Streamline) at 577-nm wavelength, using 200-μm retinal spot sizes. Using Endpoint Management Software, laser power was first titrated a barely visible burn 15-ms pulses, which defined as 100% pulse energy. Treatment then applied over area detachment adjacent...
Purpose: To evaluate the agreement of central corneal thickness (CCT) measurements between spectral-domain (SD) and swept-source (SS) optical coherence tomography (OCT) compared with gold standard ultrasonic pachymetry (US CP). Methods: Adults glaucoma suspects presenting typical optic nerve head findings high intraocular pressure or without visual field damage were included. Patients underwent anterior segment (AS) SD-OCT (Spectralis, Heidelberg Engineering), AS SS-OCT (DRI-Triton, Topcon),...
Abstract MicroRNAs (miRNAs/miRs) are involved in the pathogenesis of diabetes mellitus and its chronic complications, their circulating levels have emerged as potential biomarkers for development progression diabetes. However, few studies examined expression miRNAs diabetic retinopathy (DR) humans. This case‐control study aimed to investigate whether plasma miR‐29b miR‐200b associated with DR 186 South Brazilians type 2 (91 without DR, 46 non‐proliferative 49 proliferative DR). We also...
<h3>Background:</h3> To describe autofluorescence patterns of choroidal melanocytic lesions using the Heidelberg Retinal Angiograph 2 system (HRA2). <h3>Methods:</h3> 20 patients with in ocular fundus underwent ophthalmologic examination, photography, and optical coherence tomography (OCT). Pathologic examination was performed on one enucleated eye a large melanoma. <h3>Results:</h3> 15 had nevi 5 malignant melanoma (1 small, 1 medium 3 tumours). Choroidal did not show any characteristic...
To describe the morphologic characteristics of commotio retinae using spectral-domain optical coherence tomography and to evaluate its utility in prognosis follow-up.Consecutive patients with underwent complete ophthalmic examination, color fundus photography, tomography, autofluorescence, near-infrared autofluorescence.There were 11 eyes (8 men), a mean age 30.8 ± 12.1 years. The follow-up ranged from 9 days 6 months. Spectral-domain identified hyperreflectivity underneath inner/outer...
Abstract Background To evaluate structural changes in retina and choroid patients with type 2 diabetes (T2D) their association diabetic kidney disease (DKD). Methods T2D mild or no retinopathy (DR) were followed for 3 years using SS-OCT OCT angiography (OCT-A) taken every 6 months. Parameters compared longitudinally according to the DKD status on baseline. Results One hundred sixty eyes from 80 years, 72 (nDKD) at baseline 88 DKD. Trend analysis of showed significant thinning GCL +...
<h3>Background:</h3> This in vivo study assessed and compared the effectiveness of an aqueous indocyanine green (ICG) formulation (R-ICG) a lipid ICG (L-ICG) occluding rabbit choriocapillaris, determined singlet oxygen quantum yields aggregation properties both formulations vitro. <h3>Methods:</h3> Singlet production were compared. The eye fundus 30 albino rabbits was irradiated 0–15 min after dye injection using 810 nm diode laser. Fluorescein angiography light microscopy used to evaluate...
The purpose of this study was to describe clinical, angiographic, and tomo-graphic prognostic factors in central serous chorioretinopathy.This is a prospective uncontrolled case series. Forty-six eyes (43 patients) with clinical angiographic findings consistent chorioretinopathy were included. Clinical data regarding age, sex, duration symptoms, associated conditions, best-corrected visual acuity (BCVA) collected at baseline. Optical coherence tomography performed baseline, monthly until...
In Brief Purpose: Shorter pulses used in pattern scanning photocoagulation (10-20 milliseconds [ms]) tend to produce lighter and smaller lesions than the Early Treatment Diabetic Retinopathy Study standard 100-ms exposures. Smaller result fewer complications but may potentially reduce clinical efficacy. It is worthwhile reevaluate existing standards for number size of needed. Methods: The width coagulated zone patients undergoing retinal was measured using optical coherence tomography....
Purpose.: To determine effects of intravitreous anti-TNF-α (infliximab) in a laser-induced choroidal neovascularization (CNV) model by fluorescein angiogram (FA), immunofluorescence, ELISA, and glycosaminoglycan analyses. Methods.: CNV induction was performed using argon laser. Rats were divided into eight groups (no-laser no-infliximab; laser; laser with 10, 20, 40, 80, or 320 μg infliximab; isotype-matched IgG). After 3 weeks, area measured FA von Willebrand factor (vWF)...
Femtosecond lasers have added unprecedented precision and reproducibility to cataract surgery. However, retinal safety limits for the near-infrared employed in surgery are not well quantified. We determined injury thresholds scanning patterns while considering effects of reduced blood perfusion from rising intraocular pressure protection light scattering on bubbles tissue fragments produced by laser cutting. measured damage a stationary, 1030-nm, continuous-wave with 2.6-mm spot size 10-...