A5045316705- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Retinal and Macular Surgery
- CRISPR and Genetic Engineering
- Ophthalmology and Visual Impairment Studies
- Optical Coherence Tomography Applications
- Ocular Diseases and Behçet’s Syndrome
- Ocular Oncology and Treatments
- Intraocular Surgery and Lenses
- Advancements in Semiconductor Devices and Circuit Design
- Semiconductor materials and devices
- Pluripotent Stem Cells Research
- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Ocular Disorders and Treatments
- Advanced biosensing and bioanalysis techniques
- melanin and skin pigmentation
- Analog and Mixed-Signal Circuit Design
- RNA regulation and disease
- Cellular transport and secretion
- Cerebrovascular and Carotid Artery Diseases
- Advanced MEMS and NEMS Technologies
The University of Western Australia
2016-2025
The University of Melbourne
2022-2025
Lions Eye Institute
2016-2025
Sir Charles Gairdner Hospital
2016-2025
The Royal Victorian Eye & Ear Hospital
2023-2025
Centre for Eye Research Australia
2022-2025
Royal Perth Hospital
2015-2024
Princess Margaret Hospital for Children
2013-2024
Perth Children's Hospital
2019-2024
ORCID
2021-2024
This work introduces the use of compressed sensing (CS) algorithms for data compression in wireless sensors to address energy and telemetry bandwidth constraints common sensor nodes. Circuit models both analog digital implementations CS system are presented that enable analysis power/performance costs associated with design space any potential application, including analog-to-information converters (AIC). Results show a implementation is significantly more energy-efficient where signals...
<h3>Background</h3> Retinal prosthesis systems (RPS) are a novel treatment for profound vision loss in outer retinal dystrophies. Ideal prostheses would offer stable, long-term stimulation and reproducible spatial resolution portable form appropriate daily life. <h3>Methods</h3> We report prospective, internally controlled, multicentre trial of the Argus II system. Twenty-eight subjects with light perception received implant. Controlled, closed-group, forced-choice letter identification,...
Purpose.: The aim of this study was to investigate the repeatability manual measurements choroidal thickness in healthy subjects imaged on spectral domain optical coherence tomography (OCT) using enhanced depth imaging (EDI) technique. Methods.: Fifty consecutive, healthy, young, adult volunteers with no known eye disease were enrolled prospectively. Two good-quality horizontal and vertical line scans through fovea obtained for each eye. Using calipers provided by software proprietary...
To evaluate the impact of image magnification correction on superficial retinal vessel density (SRVD) and foveal avascular zone area (FAZA) measurements using optical coherence tomography angiography (OCTA).Participants with healthy retinas were recruited for ocular biometry, refraction, RTVue XR Avanti OCTA imaging 3 × 3-mm protocol. The parafoveal SRVD FAZA quantified custom software before after error Littman modified Bennett formulae. Relative changes between corrected uncorrected...
There is an urgent need for a more effective intervention to slow or prevent progression of age-related macular degeneration (AMD) from its early stages vision-threatening late complications. Subthreshold nanosecond laser (SNL) treatment has shown promise in preclinical studies and pilot study intermediate AMD (iAMD) as potential treatment. We aimed evaluate the safety SNL iAMD efficacy slowing AMD.The Laser Intervention Early Stages Age-Related Macular Degeneration (LEAD) 36-month,...
Background: This study examined the frequency of inherited retinal diseases (IRDs) as reason for blindness registrations over last two decades and demographic clinical phenotypes disease (IRD)-related registrations.Materials methods: Retrospective, observational individuals registered with a state-wide blind vision-impaired registry. Low-vision or blindness-only (≤20/200 ≤20°) certificates issued to children (0-15 years), working-age (16-64 years) older-age (65 older) adults were assessed....
This work presents measured results from test chips containing circuits implemented with micro-electro-mechanical (MEM) relays. The relay designed on these illustrate a range of important functions necessary for the implementation integrated VLSI systems and lend insight into circuit design techniques optimized physical properties devices. To explore hybrid electro-mechanical model relays' electrical mechanical characteristics has been developed, correlated to measurements, then also applied...
purpose. To determine the test–retest variability of retinal sensitivity Nidek MP1 microperimeter in patients with macular disease. methods. In this prospective study, 50 were enrolled a range diseases. One examiner performed two consecutive microperimetry tests for all using same test strategy. Test–retest mean (MS), deviation (MD), point-wise (PWS), local defect classification (LDC), average central macula (CMS, 16 loci inside 10°), paracentral (PMS, 52 10 to 20° ring), and dense scotoma...
Abstract The analysis of the choroid in eye is crucial for our understanding a range ocular diseases and physiological processes. Optical coherence tomography (OCT) imaging provides ability to capture highly detailed cross-sectional images yet only very limited number commercial OCT instruments provide methods automatic segmentation choroidal tissue. Manual annotation boundaries often performed but this impractical due lengthy time taken analyse large volumes images. Therefore, there...
Purpose.: To report and analyze factors influencing topographical interocular variations in choroidal thickness (CT) a healthy adult population. Methods.: One hundred eyes of 50 subjects underwent visual acuity axial length measurements optical coherence tomography (OCT) with enhanced depth imaging (EDI). CTs at the fovea 3 mm nasal, temporal, superior, inferior to were measured manually. Topographic variation, relative differences CT predictors analyzed. The relationships between age...
Abstract Deep learning methods have enabled a fast, accurate and automated approach for retinal layer segmentation in posterior segment OCT images. Due to the success of semantic adopting U-Net, wide range variants improvements been developed applied segmentation. Unfortunately, relative performance these is difficult ascertain due lack comprehensive comparative studies, proper matching between networks previous comparisons, as well use different datasets studies. In this paper, detailed...
To characterize the genotypic and phenotypic spectrum of foveal hypoplasia (FH).Multicenter, observational study.A total 907 patients with a confirmed molecular diagnosis albinism, PAX6, SLC38A8, FRMD7, AHR, or achromatopsia from 12 centers in 9 countries (n = 523) extracted publicly available datasets previously reported literature 384).Individuals availability OCT scans were identified between January 2011 March 2021. A genetic was by sequence analysis. Grading FH derived scans.Grade FH,...
To overcome the energy-efficiency limitations imposed by finite sub-threshold slope in CMOS transistors, this paper explores design of integrated circuits based on nano-electro-mechanical (NEM) relays. A dynamical Verilog-A model NEM relay is described and correlated to device measurements. Using we explore strategies for digital logic I/O that can significantly improve energy efficiency whole VLSI system. By exploiting low effective threshold voltage zero leakage achievable with these...
To overcome the energy-efficiency limitations imposed by finite sub-threshold slope in CMOS transistors, this paper explores design of integrated circuits based on nano-electro-mechanical (NEM) relays. A dynamical Verilog-A model NEM relay is described and correlated to device measurements. Using we explore strategies for digital logic I/O that can significantly improve energy efficiency whole VLSI system. By exploiting low effective threshold voltage zero leakage achievable with these...