A5020071141- Neuroscience and Neural Engineering
- Retinal and Macular Surgery
- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Intraocular Surgery and Lenses
- Retinal Imaging and Analysis
- Photoreceptor and optogenetics research
- Retinal and Optic Conditions
- Ocular Infections and Treatments
- Advanced Memory and Neural Computing
- EEG and Brain-Computer Interfaces
- Ocular Diseases and Behçet’s Syndrome
- Ocular Disorders and Treatments
- Ocular Surface and Contact Lens
- Visual perception and processing mechanisms
- Optical Coherence Tomography Applications
- Gaze Tracking and Assistive Technology
- Neurobiology of Language and Bilingualism
- Pain Management and Treatment
- Helicobacter pylori-related gastroenterology studies
- Cancer-related molecular mechanisms research
- Cytomegalovirus and herpesvirus research
- Geophysical and Geoelectrical Methods
- Optical Imaging and Spectroscopy Techniques
Centre for Eye Research Australia
2009-2025
The Royal Victorian Eye & Ear Hospital
2008-2025
The University of Melbourne
2006-2021
National University of Singapore
2021
Vision Australia
2013-2015
Moorfields Eye Hospital NHS Foundation Trust
2010-2014
University College London
2010-2014
Moorfields Eye Hospital
2010-2013
Concord Repatriation General Hospital
2001
The University of Sydney
1999
Retinal visual prostheses (“bionic eyes”) have the potential to restore vision blind or profoundly vision-impaired patients. The medical bionic technology used design, manufacture and implant such is still in its relative infancy, with various technologies surgical approaches being evaluated. We hypothesised that a suprachoroidal location (between sclera choroid of eye) would provide significant safety benefits for patients, allowing them maintain preoperative residual as well gaining...
Purpose.: The aim of this study was to investigate the repeatability manual measurements choroidal thickness in healthy subjects imaged on spectral domain optical coherence tomography (OCT) using enhanced depth imaging (EDI) technique. Methods.: Fifty consecutive, healthy, young, adult volunteers with no known eye disease were enrolled prospectively. Two good-quality horizontal and vertical line scans through fovea obtained for each eye. Using calipers provided by software proprietary...
The Argus II epiretinal prosthesis has been developed to provide partial restoration of vision subjects blinded from outer retinal degenerative disease. Participants were surgically implanted with the system in United States and Europe a single arm, prospective, multicenter clinical trial. purpose this investigation was determine which factors affect electrical thresholds order inform surgical placement device.Electrode-retina electrode-fovea distances determined using SD-OCT fundus...
Purpose.: To report and analyze factors influencing topographical interocular variations in choroidal thickness (CT) a healthy adult population. Methods.: One hundred eyes of 50 subjects underwent visual acuity axial length measurements optical coherence tomography (OCT) with enhanced depth imaging (EDI). CTs at the fovea 3 mm nasal, temporal, superior, inferior to were measured manually. Topographic variation, relative differences CT predictors analyzed. The relationships between age...
Bevacizumab (Avastin) is a monoclonal antibody which targets all isoforms of vascular endothelial growth factor A. Its potent anti-angiogenic effects have been shown to cause regression neovascularization in proliferative diabetic retinopathy. The aim this study investigate the role Avastin as an adjunct vitrectomy management severe eye disease.Sixteen patients (18 eyes) with retinopathy were recruited into study. All eyes underwent single intravitreal injection bevacizumab 1.25 mg 0.05 mL...
To determine clinical features, viral aetiology and treatment outcomes of eyes with acute retinal necrosis (ARN).Retrospective, interventional, non-comparative case series.Twenty-two patients (23 eyes) were identified between 1996 2007. Varicella zoster virus was the causative agent in 12 (nine confirmed by polymerase chain reaction), herpes simplex type 1 six (five reaction-confirmed) unknown three patients. Five had documented infection month prior to onset ARN. Twelve (55%) identifiable...
Purpose To assess the safety and efficacy of chronic electrical stimulation retina with a suprachoroidal visual prosthesis. Methods Seven normally-sighted feline subjects were implanted for 96–143 days electrode array six chronically stimulated 70–105 at levels that activated cortex. Charge balanced, biphasic, current pulses delivered to platinum electrodes in monopolar mode. Retinal integrity/function mechanical stability implant assessed monthly using electroretinography (ERG), optical...
ABSTRACT Background To assess the safety and stability profile of suprachoroidal retinal prosthesis (ScRP) in participants with retinitis pigmentosa (RP) for 2 years from implantation. Methods Four participants, advanced RP bare‐light perception vision were enrolled a prospective, single arm unmasked interventional clinical trial unilaterally implanted 44‐channel ScRP (NCT03406416). Electrical stimulation commenced psychophysics laboratory prior to use local environments. Outcome measures...
To investigate if cataract surgery causes progression, from high-risk early age-related macular degeneration (AMD) to choroidal neovascularization (CNV), in the postoperative period.Randomized controlled trial. Patients, with visually significant and fundus features of AMD at high risk progression CNV, were randomized into two groups evaluated baseline 6 months. The study patients (n = 27) underwent immediate surgery. control group 29) comprised who had deferred until after 6-month visit....
Purpose: Following successful clinical outcomes of the prototype suprachoroidal retinal prosthesis, Bionic Vision Australia has developed an upgraded 44-channel prosthesis to provide a wider field view and more phosphenes. The aim was evaluate preclinical passive safety characteristics electrode array. Methods: Ten normal-sighted felines were unilaterally implanted with array containing platinum electrodes (44 stimulating 2 returns) on silicone carrier near area centralis. Clinical...
PurposeTo assess the feasibility of a second-generation (44-channel) suprachoroidal retinal prosthesis for provision functional vision in recipients with end-stage retinitis pigmentosa (RP) over 2.7 years.DesignProspective, single-arm, unmasked interventional clinical trial.ParticipantsFour participants, advanced RP and bare-light perception vision.MethodsThe 44-channel was implanted worse-seeing eye. Device stability, functionality, adverse events were investigated at approximately 12-week...
In Brief Purpose: This study presents a series of 10 patients who posed diagnostic challenge regarding the diagnosis acquired retinoschisis (RS) or retinal detachment (RD), where spectral-domain optical coherence tomography (OCT) with Spectralis HRA and OCT device (Heidelberg Engineering, Heidelberg, Germany) was able to help make correct diagnosis. Methods: Ten (five RS five RD) were referred vitreoretinal clinic at Moorfields Eye Hospital for definitive further management. All underwent...
A key requirement for retinal prostheses is the ability safe removal or replacement. We examined whether suprachoroidal electrode arrays can be removed replaced after implantation.Suprachoroidal were unilaterally implanted into 13 adult felines. After 1 month, surgically explanted (n = 6), 5) undisturbed 2). The retina was assessed periodically using fundus photography and optical coherence tomography. Three months initial implantation, function of by measuring responses visual cortex to...
Abstract Successful visual prostheses require stable, long‐term attachment. Epiretinal prostheses, in particular, attachment methods to fix the prosthesis onto retina. The most common method is fixation with a retinal tack; however, tacks cause trauma, and surgical proficiency important ensure optimal placement of near macula. Accordingly, alternate are required. In this study, we detail novel magnetic for an epiretinal using two components positioned on opposing sides technique was piloted...
ABSTRACT Two cases are reported of delayed diffuse lamellar keratitis after uneventful laser in situ keratomileusis. The first patient presented with an epithelial defect 6 weeks Three days later the was healed but noted. This treated topical dexamethasone and ketorolac complete resolution over 3 weeks. second gross 10 Treatment ciprofloxacin gradual keratitis. Common to both patients a background rosacea, implanted debris no initial reaction, defects leading It is suggested that these two...
To describe a case of cytomegalovirus retinitis in patient after treatment with lenalidomide, novel therapy the multiple myeloma.Descriptive report 67-year-old man on Lenalidomide maintenance for myeloma, who presented unilateral painless blurring vision because retinitis.Polymerase chain reaction vitreous sampling confirmed retinitis, although patient's serum polymerase was negative cytomegalovirus. The treated ganciclovir good effect.Cytomegalovirus is rare immunocompetent patients and not...
Objective. Due to their increased proximity retinal ganglion cells (RGCs), epiretinal visual prostheses present the opportunity for eliciting phosphenes with low thresholds through direct RGC activation. This study characterised in vivo performance of a novel prototype monolithic prosthesis, containing Nitrogen incorporated ultrananocrystalline (N-UNCD) diamond electrodes. Approach. A implant up twenty-five 120 × µm N-UNCD electrodes was implanted into 16 anaesthetised cats and attached...