A5102931152- Intraocular Surgery and Lenses
- Retinal and Macular Surgery
- Glaucoma and retinal disorders
- Ocular Infections and Treatments
- Retinal Diseases and Treatments
- Neonatal Health and Biochemistry
- Family Support in Illness
- Ocular Diseases and Behçet’s Syndrome
- Glioma Diagnosis and Treatment
- Erythrocyte Function and Pathophysiology
- Advanced Glycation End Products research
- Retinal and Optic Conditions
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroscience and Neural Engineering
- Heme Oxygenase-1 and Carbon Monoxide
- Palliative Care and End-of-Life Issues
- Electrochemical sensors and biosensors
- Long-Term Effects of COVID-19
- Ethics in Clinical Research
- Meta-analysis and systematic reviews
- Infection Control and Ventilation
- Parvovirus B19 Infection Studies
- Hemoglobinopathies and Related Disorders
- Tryptophan and brain disorders
- Clinical Laboratory Practices and Quality Control
Massachusetts General Hospital
2023-2024
Center for Neuro-Oncology
2024
Dana-Farber Cancer Institute
2023-2024
Harvard University
2023
The Royal Victorian Eye & Ear Hospital
2007-2021
Chang Gung University
2000-2020
Centre for Eye Research Australia
2007-2019
Chang Gung Memorial Hospital
2008-2017
Linkou Chang Gung Memorial Hospital
2011-2016
Memorial Hospital of South Bend
2011
In Brief Purpose: To evaluate the clinical outcome of intravitreal tissue plasminogen activator (tPA) and expansile gas injection as a minimally invasive treatment for submacular hemorrhage (SMH). Methods: This study was retrospective case series examining 104 eyes that received an 30–100 mcg tPA (SF6 or C3F8) SMH. The main outcomes evaluated were visual acuities (VA), anatomic displacement blood, surgical complications. Results: A total 85, 77, 81 available at 1 week, 3 months, 12 months...
Bevacizumab (Avastin) is a monoclonal antibody which targets all isoforms of vascular endothelial growth factor A. Its potent anti-angiogenic effects have been shown to cause regression neovascularization in proliferative diabetic retinopathy. The aim this study investigate the role Avastin as an adjunct vitrectomy management severe eye disease.Sixteen patients (18 eyes) with retinopathy were recruited into study. All eyes underwent single intravitreal injection bevacizumab 1.25 mg 0.05 mL...
Abstract Aims/Introduction Diabetic nephropathy is one of the leading causes end‐stage renal disease. Unfortunately, reliable surrogate markers for predicting prognostic outcome diabetic are as yet absent. In order to find new in progression nephropathy, we carried out a prospective study by investigating correlation between serum metabolites and annual change estimated glomerular filtration rate ( eGFR ). Materials Methods From September 2013 2015, 52 diabetes patients at various stages...
Object Oxidative stress may play a role in spontaneous intracerebral hemorrhage (ICH), but data on oxidative burden cerebral are limited, and it is not clear whether markers add predictive power regarding ICH outcome beyond that of traditional factors. The authors therefore examined redox status factors patients within 3 days onset to delineate investigate the value with respect 30-day functional outcome. Methods Sixty-four 114 controls were prospectively enrolled this study. Blood samples...
Intravenous drug use (IVDU) is a known risk factor for endogenous endophthalmitis. Endogenous fungal endophthalmitis (EFE) emerging as common problem among this community. We describe the management and visual outcomes of acute IVDU-associated EFE.A prospective consecutive case series 19 patients presenting with presumed EFE from 2001 to 2007 Royal Victorian Eye Ear Hospital was included. All data were collected in standardized manner. Outcome measures included acuity, microbial profiles,...
Background Accurate patient identification and specimen labeling at the time of collection are crucial steps in prevention medical errors, thereby improving safety. Methods All errors that occurred outpatient department (OPD), emergency (ED), inpatient (IPD) a 3,800-bed academic center Taiwan were documented analyzed retrospectively from 2005 to 2014. To reduce such following series strategies implemented: restrictive acceptance policy for ED IPD 2006; computer-assisted barcode positive...
Albuminuria is a measurement and determinant factor for diabetic kidney disease (DKD). Angiotensin receptor blocker (ARB) recommended albuminuria in DKD with variable response. To find surrogate markers to predict the therapeutic effect of ARB, we carried out prospective study correlate plasma metabolites progression renal function/albuminuria patients. A total 56 type 2 patients various stages chronic were recruited. ARB was prescribed once established. Urinary albumin-to-creatinine ratio...
Glucose‐6‐phosphate dehydrogenase (G6PD) plays an important role in cellular redox homeostasis, which is crucial for cell survival. In the present study, we found that G6PD status determines response of cells exposed to nitric oxide (NO) donor. Treatment with NO donor, sodium nitroprusside (SNP), caused apoptosis G6PD‐deficient human foreskin fibroblasts (HFF1), whereas it was growth stimulatory normal counterpart (HFF3). Such effects were abolished by scavengers like hemoglobin. Ectopic...
Guillain-Barre Syndrome (GBS) is an inflammatory disease of the peripheral nervous system. Given that plasma metabolic profiles in GBS patients have never been explored, samples 38 patients, 22 multiple sclerosis (MS) and 40 healthy controls were analyzed by using untargeted targeted metabolomics analysis. The analysis showed levels a set lipid metabolites significantly decreased compared to controls. Furthermore, demonstrated 41 changed either or MS patients. A further 12 lower classical...
G6PD deficiency may render afflicted individuals more susceptible to certain degenerative diseases. To clarify the relationship between and cataract, blood activity was determined in patients with cataract Taiwan. The cases hospital-based controls were recruited from medical outpatient department physical checkup at Chang Gung Memorial Hospital, respectively. A questionnaire survey used determine associations cataracts their risk factors. fresh RBC quantitatively measured genomic DNA...
Abstract Background Lower-grade (WHO grades 2–3) gliomas typically affect young and middle-aged adults exhibit isocitrate dehydrogenase (IDH) mutations. For such patients, symptoms related to the tumor associated treatment contribute morbidity erode quality of life. With improved treatment, a better understanding these effects over time is critically needed. Existing data characterizing unmet needs lower-grade glioma patients limited little consensus exists on addressing in clinical...
12110 Background: Caregivers of patients with primary malignant brain tumors (PMBT) experience immense psychological distress and lack tailored supportive care resources. In a recently completed randomized controlled trial, we demonstrated that brief telehealth-based intervention (“NeuroCARE”) for caregivers PMBT led to decreased anxiety depression symptoms as well greater caregiving self-efficacy coping ability compared usual (UC). To explore active drivers the intervention, examined...
Abstract BACKGROUND In a recent randomized controlled trial, caregivers of patients with primary malignant brain tumors (PMBT) who received NeuroCARE—a six-session, telehealth-based psychological intervention—demonstrated improved anxiety and depression symptoms, coping, self-efficacy at 11-weeks compared to usual care (UC) participants. We now explore how sociodemographic variables, disease-specific factors, baseline mood symptoms moderate intervention effects on symptoms. METHODS examined...
Abstract BACKGROUND Caregivers of patients with malignant gliomas (MG) experience considerable psychological distress as they contend the implications their loved one’s terminal illness. However, caregivers’ specific reactions to patient’s diagnosis/prognosis and optimal ways support caregivers in months following diagnosis remain poorly understood. METHODS At a single academic medical center, we enrolled English-speaking adults identified by newly diagnosed MG primary caregiver. Using...