A5074959788- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Diabetes Treatment and Management
- Diabetes Management and Research
- BRCA gene mutations in cancer
- Head and Neck Anomalies
- Cardiovascular Health and Disease Prevention
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Thyroid Disorders and Treatments
- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Diabetes and associated disorders
- Hormonal Regulation and Hypertension
- Adrenal Hormones and Disorders
- Peripheral Artery Disease Management
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Blood Pressure and Hypertension Studies
- Drug Transport and Resistance Mechanisms
- Gut microbiota and health
- Ophthalmology and Eye Disorders
- Nitric Oxide and Endothelin Effects
- Cardiovascular Function and Risk Factors
- Chronic Kidney Disease and Diabetes
Chang Gung Memorial Hospital
2012-2024
Linkou Chang Gung Memorial Hospital
2018-2024
Chang Gung University
2012-2022
GTx (United States)
2019
Thyroid nodule is common disorder in endocrine clinics. In Taiwan, thyroid ultrasonography with fine-needle aspiration cytology (FNAC) the first-line examination procedure. Data large series on incidence of malignancy presenting nodules are lacking this area. To determine and compare results other populations, investigation retrospectively reviewed 21,748 subjects who were examined one medical center from January 1986 to December 1999. All patients underwent studies using a real-time...
Graves’ disease (GD) is a systemic autoimmune characterized by hyperthyroidism. Evidence suggests that alterations to the gut microbiota may be involved in development of disorders. The aim this study was characterize composition GD patients. Fecal samples were collected from 55 patients and 48 healthy controls. Using 16S rRNA gene amplification sequencing, overall bacterial richness diversity found similar between However, principal coordinate analysis partial least squares-discriminant...
Abstract Diabetic nephropathy is a critical complication of patients with type 1 diabetes, while epidemiological studies were scarce among Asian countries. We conducted cross-sectional study to identify factors associated diabetic by questionnaires, using student’s t-test, chi-square test, and multivariable logistic regression. Among 898 participants, 16.7% had nephropathy. Compared non-diabetic patients, the significantly higher percentage onset age diabetes between puberty under 30 years...
Abstract Aims/Introduction Diabetic nephropathy is one of the leading causes end‐stage renal disease. Unfortunately, reliable surrogate markers for predicting prognostic outcome diabetic are as yet absent. In order to find new in progression nephropathy, we carried out a prospective study by investigating correlation between serum metabolites and annual change estimated glomerular filtration rate ( eGFR ). Materials Methods From September 2013 2015, 52 diabetes patients at various stages...
Subclinical hypothyroidism (SCH) is defined as elevation in serum thyroid-stimulating hormone (TSH) levels despite normal of free thyroxine. It remains controversial whether people with SCH have higher total cholesterol and low-density lipoprotein compared to normal-thyroid subjects. The aim this study was assess the metabolic risk factors for SCH.Subjects were recruited from health examination center Chang Gung Memorial Hospital, Linkou, January 1, 2010 December 31, 2011. This a...
Many patients with papillary thyroid cancer (PTC) demonstrate satisfactory outcomes. However, 8%–28% of PTC show tumor recurrence, which may affect prognosis. Therefore, identifying factors associated recurrence in be helpful to refine therapeutic strategies. To identify we retrospectively reviewed demographic features (sex and age), operation method, image character, serum thyroglobulin (Tg), accumulated radioactive iodine (I-131) dose, I-131 uptake, metastases at diagnosis 829 PTC....
A retrospective review of 626 patients with multifocal papillary thyroid carcinoma (PTC) including 147 (23.5%) microcarcinoma (PTMC) from a total 2,536 PTC who visited the Chang Gung Medical Center in Linkou, Taiwan, was performed. comparison clinical features between and 1,910 solitary cases showed that group were older had smaller mean tumor size, more advanced tumor-node-metastasis (TNM) stage, higher percentage nonremission status compared to group. Of PTC, larger tumors TNM lymph node...
Radiofrequency ablation (RFA) is a minimally invasive management strategy that has been widely applied for benign and recurrent malignant thyroid lesions as an alternative to surgery in Taiwan. Members of academic societies specialists interventional radiology, endocrinology, endocrine collaborated develop the first consensus regarding RFA The modified Delphi method was used reach consensus. Based on comprehensive review recent valuable literature expert opinions, recommendations included...
The aims of this study were to investigate papillary and follicular thyroid carcinomas with bone metastasis in various clinical presentations determine the prognostic factors after multimodality treatment. A retrospective analysis was performed 3,120 patients carcinoma. Of these patients, 131 (including 97 women, 71.8%) diagnosed underwent follow-up at Chang Gung Medical Center. Patients categorized into two groups. Group comprised who either before thyroidectomy or within 6 months initial...
The cardiovascular safety and efficacy of linagliptin, a dipeptidyl peptidase-4 inhibitor, in patients with type 2 diabetes mellitus (T2DM) after acute coronary syndrome (ACS) or ischemic stroke (AIS) are unclear. aim our real-world cohort study was to evaluate the outcomes linagliptin T2DM ACS AIS. An open observational noncrossover retrospective conducted between June 1, 2012 December 31, 2013 utilizing Taiwan National Health Insurance Research Database. A total 1203 AIS were selected as...
The aim of this study was to explore the effect and action mechanisms intermittent hypoxia on production testosterone both in vivo vitro. Male rats were housed a hypoxic chamber (12% O(2) + 88% N(2), 1.5 l/ml) 8 h/day for 4 days. Normoxic used as control. In an experiment, normoxic euthanized blood samples collected. vitro enzymatically dispersed rat Leydig cells prepared challenged with forskolin (an adenylyl cyclase activator, 10(-4) M), 8-Br-cAMP (a membrane-permeable analog cAMP, hCG...
Objective: The objective of this study was to investigate the effects sodium-glucose cotransporter 2 (SGLT2) inhibitors on renal function in different stages chronic kidney disease (CKD). Design and Methods: We conducted a retrospective cohort using longitudinal claims data from May 2016-December 2017 Chang Gung Research Database. Patients who used one three types SGLT2 inhibitor available at Memorial Hospital, namely empagliflozin 10 mg/tab (Empa10), 25 (Empa25), dapagliflozin (Dapa), were...
Primary aldosteronism (PA) is a common cause of secondary hypertension. Among the many leading causes PA, two most frequent are, bilateral adrenal hyperplasia (BAH) and aldosterone-producing adenomas (APA). Since solitary APA may be cured surgically, but BAH needs lifelong pharmacologic therapy, confirmation mandatory before surgery. We herein sought to determine diagnostic value iodine-131 6-beta-iodomethyl-19-norcholesterol (NP-59) scintigraphy distinguish from APA.Patients clinically...
Differentiated thyroid cancer (DTC) from follicular epithelial cells is the most common form of cancer. Beyond papillary carcinoma (PTC), there are a number rare but difficult-to-diagnose pathological classifications, such as (FTC). We employed deep convolutional neural networks (CNNs) to facilitate clinical diagnosis differentiated cancers. An image dataset with ultrasound images 421 DTCs and 391 benign patients was collected. Three CNNs (InceptionV3, ResNet101, VGG19) were retrained tested...
Albuminuria is a measurement and determinant factor for diabetic kidney disease (DKD). Angiotensin receptor blocker (ARB) recommended albuminuria in DKD with variable response. To find surrogate markers to predict the therapeutic effect of ARB, we carried out prospective study correlate plasma metabolites progression renal function/albuminuria patients. A total 56 type 2 patients various stages chronic were recruited. ARB was prescribed once established. Urinary albumin-to-creatinine ratio...
Abstract The regenerative effect of Epimedium and its major bioactive flavonoid icariin (ICA) have been documented in traditional medicine, but their on sarcopenia has not evaluated. aim this study was to investigate the effects extract (EE) skeletal muscle as represented by differentiated C2C12 cells. Here we demonstrated that EE ICA stimulated myotube hypertrophy activating several, including IGF-1 signal pathways. enlarged increased myosin heavy chains (MyHCs). In similar IGF-1, EE/ICA...
Background Increased body mass index is related to the incidence of thyroid cancer. However, presentation and therapeutic outcomes different cancers type 2 diabetes mellitus (DM) have not been studied. This study investigated effect DM on clinical presentations outcome well-differentiated Methods Findings A retrospective analysis adult cancer patients with or without admitted between January 2001 December 2010 was performed at an institution. total 1,687 histological patterns were enrolled....
Radioactive iodine (I) has been used as a treatment for high-risk well-differentiated thyroid cancer after thyroidectomy. The aim of this study was to evaluate the long-term follow-up results using high accumulated doses I (>600 mCi) cancer.In study, we retrospectively evaluated prospectively enrolled patients with who were treated and followed up in Chang Gung Memorial Hospital Linkou Keelung, Taiwan. All underwent thyroidectomy between 1979 2016.For our 228 papillary follicular carcinoma...
The reported outcomes of the metabolic syndrome (MetS), containing atherosclerotic cardiovascular disease and diabetes, vary according to definitions used. This study was designed compare performance Adult Treatment Panel III/American Heart Association/National Heart, Lung, Blood Institute (ATP III/AHA/NHLBI) International Diabetes Federation (IDF) criteria for risks atherosclerosis diabetes. We sifted subjects from a self-paid Health examination program 1999 2015 in this cross-sectional...
The objectives of this study were to evaluate the associations between clinical parameters and quality life (QOL) patients with acromegaly in Taiwan identify impacts hormone control, regimens, or co-morbidities on acromegalic patients' daily life.From 2013 2015, subjects recruited through five medical centers. Clinical data recorded. QOL enrolled assessed by using Acromegaly Quality Life Questionnaire (AcroQoL).This 272 (117 males, 155 females). Remission, defined normalization IGF-1, had...