A5100599536- Plant Molecular Biology Research
- Plant-Microbe Interactions and Immunity
- Plant Stress Responses and Tolerance
- RNA Interference and Gene Delivery
- Neurological Disease Mechanisms and Treatments
- RNA modifications and cancer
- MicroRNA in disease regulation
- Hepatitis B Virus Studies
- Nanoparticle-Based Drug Delivery
- Cancer, Hypoxia, and Metabolism
- biodegradable polymer synthesis and properties
- Carbon dioxide utilization in catalysis
- Glioma Diagnosis and Treatment
- Microwave Engineering and Waveguides
- Food composition and properties
- Angiogenesis and VEGF in Cancer
- Virus-based gene therapy research
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Galectins and Cancer Biology
- Advanced biosensing and bioanalysis techniques
- Cancer, Lipids, and Metabolism
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Glycosylation and Glycoproteins Research
- Estrogen and related hormone effects
Zhujiang Hospital
2025
Cathay General Hospital
2019-2025
National University of Kaohsiung
2025
Zhejiang University
2024-2025
Southern Medical University
2025
Fujian Medical University
2020-2025
Agricultural Biotechnology Research Center, Academia Sinica
2018-2024
Sichuan University
2022-2024
China Southern Power Grid (China)
2023-2024
Ministry of Health and Welfare
2014-2024
MicroRNAs (miRNAs) are small non-coding RNAs of approximately 22 nucleotides, which negatively regulate the gene expression at post-transcriptional level. This study describes an update miRTarBase (http://miRTarBase.mbc.nctu.edu.tw/) that provides information about experimentally validated miRNA-target interactions (MTIs). The latest expanded it to identify systematically Argonaute-miRNA-RNA from 138 crosslinking and immunoprecipitation sequencing (CLIP-seq) data sets were generated by 21...
MicroRNAs (miRNAs) are small non-coding RNA molecules capable of negatively regulating gene expression to control many cellular mechanisms. The miRTarBase database (http://mirtarbase.mbc.nctu.edu.tw/) provides the most current and comprehensive information experimentally validated miRNA-target interactions. was launched in 2010 with data sources for >100 published studies identification miRNA targets, molecular networks targets systems biology, release (2013, version 4) includes significant...
In this paper, an SVM-based approach is proposed for stock market trend prediction. The consists of two parts: feature selection and prediction model. the part, a correlation-based SVM filter applied to rank select good subset financial indexes. And indicators are evaluated based on ranking. model so called quasi-linear predict movement direction in term historical data series by using selected indexes as weighted inputs. with composite kernel function, which approximates nonlinear...
Gastric cancer is currently the fourth leading cause of cancer-related death worldwide. often diagnosed at advanced stages and outcome treatment poor. Therefore, identifying new therapeutic targets for this urgently needed. Integrin alpha 2 (ITGA2) subunit beta 1 form a heterodimer transmembrane receptor extracellular matrix, an important molecule involved in tumor cell proliferation, survival migration. α2β1 over-expressed on variety cells, but low or absent most normal organs resting...
Abstract Peripheral blood lymphocytes (PBLs) are mature that circulate in the rather than being localized to organs. A reliable label-free collection approach can viably and appropriately isolate PBLs establish vitro culture systems is crucial for basic research clinical requirements. However, isolation of from whole difficult, so development a rapid safe method perform this task required. Microfluidic technology offers opportunities challenge performance macroscale methods. In study, we...
Abstract BPC 157-activated endothelial nitric oxide synthase (eNOS) is associated with tissue repair and angiogenesis as reported in previous studies. However, how 157 regulates the vasomotor tone intracellular Src-Caveolin-1 (Cav-1)-eNOS signaling not yet clear. The present study demonstrated a concentration-dependent vasodilation effect of isolated rat aorta. Attenuation this absence endothelium suggested an endothelium-dependent 157. Although slightly increased vasorelaxation aorta...
Abstract Diabetic nephropathy is a critical complication of patients with type 1 diabetes, while epidemiological studies were scarce among Asian countries. We conducted cross-sectional study to identify factors associated diabetic by questionnaires, using student’s t-test, chi-square test, and multivariable logistic regression. Among 898 participants, 16.7% had nephropathy. Compared non-diabetic patients, the significantly higher percentage onset age diabetes between puberty under 30 years...
Chemical synthesis of polymers from carbon dioxide (CO2) has been attracting a continuous amount attention. This contribution explores the copolymerization ethylidene-6-vinyltetrahydro-2H-pyran-2-one (EVL) synthesized CO2 and 1,3-butadiene with various cyclic carbonates (CC) derived biomass diols. Following "scrambling polymerizations" mechanism, EVL units are incorporated into polycarbonate backbones, resulting in random poly(ester-co-carbonate) P(EVL-co-CC) functionalizable C═C double...
Background: Recent evidence supports the protective role of metformin on kidney function in patients with type 2 diabetes mellitus. However, its potential to prevent new-onset chronic disease (CKD) mellitus normal renal remains unclear. Therefore, this study aimed investigate whether could development CKD such patients. Methods: This retrospective, observational, multicenter cohort included 316,693 After matching using inverse probability treatment weighting, 9109 users and 1221 nonusers...
The challenging ring-opening homopolymerization of α-ethylidene-δ-vinyl-δ-valerolactone (EVL), derived from CO2 and 1,3-butadiene, has aroused extensive attention in consideration economic efficiency functionalization potential. In the contribution, we achieve first cationic polymerization (CROP) EVL through a carbenium-based mechanism, yielding well-defined cyclic polyester PEVL with number-average molecular weight (Mn) up to 12.8 kg/mol low dispersity 1.2. CROP results containing two kinds...
Traditional antimicrobial-susceptibility testing methodologies, including the isolation and culture of bacteria from urine samples antibiotic-susceptibility test (AST), are expensive time-consuming. Therefore, a rapid, user-friendly phenotypic AST is urgently needed to guide treatment strategies. Several novel platforms based on physiological characteristics obtained directly clinical have been proposed as promising methods rapid appropriate antibiotic treatments. However, inaccurate...
Abstract Transplantation of mesenchymal stem cells (MSCs) is beneficial in myocardial infarction and hind limb ischemia, but its ability to ameliorate atherosclerosis remains unknown. Here, the effects MSCs on inhibiting endothelial dysfunction were investigated human/mouse treated with oxidized low-density lipoprotein (oxLDL) apolipoprotein E-deficient (apoE−/−) mice fed a high-fat diet. Treatment oxLDL inactivated Akt/endothelial nitric-oxide synthase (eNOS) pathway, induced eNOS...
Tamoxifen is currently used for the treatment of both early and advanced estrogen receptor (ER) positive breast cancer in pre- post-menopausal women. However, using tamoxifen routinely to inhibit endogenous or exogenous effects occasionally difficult because its potential side effects. The aim this study design a local drug delivery system encapsulate observing their efficacy skin penetration, accumulation therapy. A cationic liposome-PEG-PEI complex (LPPC) was as carrier encapsulation...
In this study, novel aminothiazole-paeonol derivatives were synthesized and characterized using 1H-NMR, 13C-NMR, IR, mass spectroscopy, high performance liquid chromatography. All the new compounds evaluated according to their anticancer effect on seven cancer cell lines. The experimental results indicated that these possess potential regarding human gastric adenocarcinoma (AGS cells) colorectal (HT-29 cells). Among compounds,...
The objective of this study was to establish analytical approaches quantify 1,3-β-glucan (1,3-β-G) in foods. Six food categories including legumes, cereals, tubers, vegetables, fruits, and mushrooms 17 total items were tested. An extraction procedure designed prepare cold-water soluble, hot-water cold-alkaline hot-alkaline soluble fractions. A fluorescence microassay based on aniline blue dye, which bound specifically 1,3-β-G, developed measure its content the Curdlan used as standard...
A cationic liposome-PEG-PEI complex (LPPC) was employed as a carrier for achieving targeted delivery of drug to human epidermal growth factor receptor-2 (HER2/neu)-expressing breast cancer cells. LPPC can be easily loaded with an anti-tumor and non-covalently associated antibody such Herceptin that is clinically used rapidly form immunoparticles within 1 h.Drug-loaded have average size about 250 nm zeta potential 40 mV. complexed onto surface the drug/LPPC/Herceptin complexes. The...