Traditional antimicrobial-susceptibility testing methodologies, including the isolation and culture of bacteria from urine samples antibiotic-susceptibility test (AST), are expensive time-consuming. Therefore, a rapid, user-friendly phenotypic AST is urgently needed to guide treatment strategies. Several novel platforms based on physiological characteristics obtained directly clinical have been proposed as promising methods rapid appropriate antibiotic treatments. However, inaccurate...

Fumonisins (Fums) are types of mycotoxin that widely contaminante feed material crops, and can trigger potential biological toxicities to humans various animals. However, the toxicity Fums on porcine blood vessels has not been fully explored. Fumonisin B1 (FB1) is main component Fums. Therefore, aim this study was explore effects FB1 oxidative stress tight junctions pig iliac endothelial cells (PIECs) in vitro. The results showed reduced viability PIECs, increased contents lipid peroxidation...

Dendrite-like cobalt selenide nanostructures were synthesized from and selenium powder precursors by a solvothermal method in anhydrous ethylenediamine. The as-prepared nanocrystalline was found to possess peroxidase-like activity that could catalyze the reaction of peroxidase substrates presence H2O2. A spectrophotometric for uric acid (UA) determination developed based on selenide-catalyzed coupling between N-ethyl-N-(3-sulfopropyl)-3-methylaniline sodium salt 4-aminoantipyrine (4-AAP)...

Abstract Gastric cancer (GC) is one hackneyed malignancy tumor accompanied by high death rate. DKC1 has been discovered to serve as a facilitator in several cancers. Additionally, it was from study that displayed higher expression GC tissues than the normal tissues. Nevertheless, its role and regulatory mechanism yet be illustrated. In this study, proved upregulated through GEPIA UALCAN databases. Moreover, we exhibited cells. Functional experiments testified accelerated cell proliferation,...

Background: Laparoscopic resection is increasingly used in colorectal cancer (CRC). It has been suggested to carry short-term benefits safety, recovery, and preservation on immune function for patients with CRC. However, the impact of laparoscopic natural killer (NK) cells largely unclear. Methods: A total 200 CRC across Dukes A/B/C stages were randomly assigned or open resection. The blood samples collected before after surgery. number NK was quantified by flow cytometer. Lytic units 35...

BACKGROUND: Worldwide, cervical cancer is the fouth leading cause of deaths in gynecological oncology. Although causes have been extensively investigated, understanding its exact pathogenesis remains incomplete. OBJECTIVE: This study aimed to identify alterations genome and transcriptome HPV associated using multi-omics approaches. METHODS: Cervical matched adjacent non-tumor specimens one HPV16+ two HPV- patients were sampled for whole-exome sequencing (WES) RNA characterize DNA mutations...

ABSTRACT The vaginal microbiome (VM) is associated with human papillomavirus (HPV) infection and progression, but a thorough understanding of the relation between HPV infection, VM needs to be elucidated. From August December 2022, women who underwent routine gynecological examinations were screened for infection. distribution variants clinical characteristics collected. Then, total 185 participants enrolled divided into HPV-negative (HC), high-risk (H), low-risk (L), multiple (HH), mixed...

This study aimed to evaluate the prognostic value and biological function of small ubiquitin‐like modifier 2 ( SUMO2 ) in hepatocellular carcinoma (HCC). expression HCC tissues was markedly higher than that normal liver tissues, patients with high had significantly shorter median overall survival those low expression. Furthermore, closely correlated lymph node metastasis vascular invasion a predictor poor prognosis. The knockdown two cell lines (SMMC‐7721 Bel‐7404) dramatically suppressed...

This work reports on polymer-antibiotic conjugates (PACs) as additives to resin-based restorative dental materials a new strategy convey sustained antibacterial character these materials. Such performance is expected improve their longevity in the oral cavity. Using previously reported ciprofloxacin (Cip)-based PAC control, penicillin V (PV)-based was investigated. The monomer-antibiotic conjugate (MAC) containing methacrylate monomer group and PV moiety prepared via nucleophilic...

Recent studies have exposed that voice assistants can be manipulated by various commands without being noticed, however, existing attacks require a nearby speaker to play the attack commands. In this paper, we demonstrate even speaker, use capacitors inside electronic devices produce malicious commands, i.e., convert into speakers and call it <monospace xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CapSpeaker</monospace> . The underlying principle...

Abstract Background Genital HPV infection is a common public health issue that causes huge burden with potential oncogenicities. The vaginal microbiome (VM) associated and progression, but thorough understanding of the relation between different types VM needs to be elucidated. Methods From August December 2022, women who underwent routine gynecological examinations were screened for infection. distribution variants was recorded, clinical characteristics collected. Then, total 185...

MicroRNAs (miRNAs) are endogenous, noncoding, and sequence-specific single-stranded RNA regulatory factors whose abnormal expression levels closely related to various diseases, especially cancer, considered effective biomarkers for disease diagnosis prognosis. Since the concentrations of miRNAs in body low by detecting single may result a high false positive, it is essential construct sensitive biosensor determination multiple miRNAs. In this work, an enzyme-free signal amplification assay...

Sensors are key components enabling various applications, e.g., home intrusion detection and environmental monitoring. While software defenses physical protections used to prevent sensor manipulation, this paper introduces a new threat vector, PowerRadio, that bypasses existing changes readings from distance. PowerRadio leverages interconnected ground (GND) wires, standard practice for electrical safety at home, inject malicious signals. The injected signal is coupled by the sensor's analog...

To investigate the gene prevalence and spectrum of thalassemia in women childbearing age quanzhou area.Venous blood were collected for study, all subjects registered each county area by using cluster sampling. Both mean corpuscular volume (MCV) hemoglobin (MCH) used screening thalassemia．Genotyping screened positive samples was performed gap single polymerase chain reaction (gap-PCR) reverse dot blot (RDB) hybridization．Unknown analyzed with DNA sequencing.Out 7 082 samples, Three hundred...

A novel capacitance immunosensor based on DNAzyme concatemer-amplified signal-generation tags was developed for the sensitive detection of interleukin-6 (IL-6) an interdigitated micro-comb electrode.