A5100375628- Genetics and Neurodevelopmental Disorders
- Genomic variations and chromosomal abnormalities
- Pneumonia and Respiratory Infections
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Autism Spectrum Disorder Research
- Immune Cell Function and Interaction
- Respiratory viral infections research
- Sperm and Testicular Function
- Cytokine Signaling Pathways and Interactions
- Cleft Lip and Palate Research
- Cellular Mechanics and Interactions
- Antibiotic Resistance in Bacteria
- CRISPR and Genetic Engineering
- Assisted Reproductive Technology and Twin Pregnancy
- Congenital heart defects research
- Inflammatory Bowel Disease
- Escherichia coli research studies
- Craniofacial Disorders and Treatments
- Reproductive System and Pregnancy
- Tryptophan and brain disorders
- Nuclear Receptors and Signaling
- Atherosclerosis and Cardiovascular Diseases
- Genetics and Physical Performance
- Immune cells in cancer
- Skin and Cellular Biology Research
Hunan Cancer Hospital
2024
Central South University
2022-2024
Binzhou Medical University
2024
Binzhou University
2024
Xiamen University
2020-2022
Xiamen Maternal and Child Health Hospital
2021-2022
Lishui University
2022
Second Xiangya Hospital of Central South University
2022
Second Affiliated Hospital of Nanchang University
2018
Nanchang University
2018
To evaluate the therapeutic effects of a probiotic supplement (Clostridium butyricum, CGMCC0313) in chemically-induced rat model experimental colitis.An ulcerative colitis was established by rectal injection oxazolone into colon 40 Wistar rats randomly divided four groups. The positive control group sacrificed 3 d after onset. remaining groups were fed daily with either 2 mL C. butyricum (2.3 x 10(11) CFU/L), mesalamine (100 g/L), or 1 sodium butyrate (50 mmol/L) for 21 d. animals' body...
Abstract Myeloid-derived suppressor cells (MDSCs) play a crucial role in maintaining maternal-fetal tolerance by expressing some immune-suppressive molecules, such as indoleamine 2,3-dioxygenase (IDO). Toxoplasma gondii ( T. ) infection can break the immune microenvironment of interface, resulting adverse pregnancy outcomes. However, whether affects IDO expression dMDSCs and molecular mechanism its effect are still unclear. Here we show, mRNA level is increased but protein decreased infected...
To investigate the etiology of common respiratory pathogens in children < 2 years age hospitalized with pneumonia Xiamen from 2014 to 2017.
Background: A crucial part of the malignant processes soft tissue sarcoma (STS) is played by cuproptosis and lncRNAs. However, connection between cuproptosis-related lncRNAs (CRLs) STS nevertheless unclear. As a result, our objective was to look into immunological activity, clinical significance, predictive accuracy CRLs in STS. Methods: The Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) databases, respectively, provided information on expression patterns patients general...
Abstract The emergence of multidrug resistance in bacteria has reached alarming levels. To solve this growing problem, discovery novel cellular targets or pathways important for antimicrobial is urgently needed. In study, we explored how the alternative sigma factor, RpoE, protects Escherichia coli O157 against toxic effects polycationic agent, chlorhexidine (CHX). Susceptibility organism to CHX was found directly correlate growth rate, with faster replicating wild‐type being more...
Pachyonychia congenita (PC) is a rare genetic disorder which inherited in an autosomal dominant pattern. We report sporadic novel H1 mutation the KRT6A gene (c. 428G>A/p.Ser143Asn) Chinese infant patient. The concurrent with single-nucleotide polymorphism and resulted serine for asparagine substitution subdomain of chain next to rod domain. showed classic symptoms pachyonychia congenita.The heterozygous missense c. 428G > A/p.Ser143Asn exon 1 may cause severe disease.
Well-established surveillance and monitoring systems for respiratory viruses need to be improved, epidemiological data on in China are scarce. This study aimed investigate the characteristics of among hospitalized children aged ≤2 years with acute tract infections (ARTIs) Xiamen, China, from October 2014 September 2017. The clinical records 7,248 ARTIs were retrospectively analyzed. Respiratory syncytial virus (RSV) (22.3%) was most common years, followed by parainfluenza (5.0%), adenovirus...
To carry out genetic analysis on two families with carriers of small terminal translocations using karyotyping and genomic copy number variation sequencing (CNV-seq).
To assess the value of chromosomal microarray analysis (CMA) for diagnosis children with intellectual disability/developmental delay (ID/DD) but a normal karytype.Peripheral blood samples from 92 ID/DD patients were analyzed CMA using Affymetrix CytoScan 750K arrays. The results by ChAS v3.0 software.Eighteen cases (19.57%) detected abnormalities CMA, among which 10 diagnosed microdeletion/microduplication syndromes. These included 2 Williams-Beuren syndromes, Angelman Russell-Silver 1...
Objective To investigate whether the WNK lysine deficient protein kinase 4 （WNK4） gene C1155547T polymorphism is associated with essential hypertension （EH） in Xinjiang Kazakhs and to assess effect of interaction between this environment factors on EH. Methods The studycovered 556 patients 341 normotensive controls. was determined by Taqman probe real-time PCR method. Some biochemical index such as glucose, triglyceride total cholesterol were also measured. All these results analyzed...
Abstract Identification of carriers fragile X syndrome (FXS) with the subsequent prenatal diagnosis, and knowledge FXS-associated genetic profiles are essential for intervention in specific populations. We report results carrier screening 39,458 East Asian adult women diagnosis from 87 FXS carriers. The prevalence incidence full mutation fetuses pregnancies were found to be 1/556 11.0%, respectively. was estimated 1/581 1/3124 populations, confirmed validity current threshold CGG repeats...
Identification of carriers fragile X syndrome (FXS) with the subsequent prenatal diagnosis, and knowledge FXS-associated genetic profiles are essential for intervention in specific populations. We report results carrier screening 39,458 East Asian adult women diagnosis from 87 FXS carriers. The prevalence incidence full mutation fetuses pregnancies were found to be 1/556 11.0%, respectively. confirmed validity current threshold CGG repeats FMR1 categorization; integral risks expansion...
Crematogaster matsumurai (Forel 1901) is an important arboreal ant species commonly found on Phyllostachys heterocycla (Carr.) in Lishui, Zhejiang, China. This study analyzed the mitochondrial genome sequence of C. and discussed its phylogenetic relationship Hymenoptera. The circular was 16,028 bp long, including a standard set 22 transfer RNAs (tRNAs), two ribosomal (rRNAs), 13 protein-coding genes (PCGs), which showed typical insect arrangement. AT GC contents were 76.92% 23.08%,...
Abstract Klinefelter syndrome (KS) is one of the most frequent genetic abnormalities and leading cause non-obstructive azoospermia. The breeding mouse models KS their study are essential to advance our knowledge pathologic mechanism. Karyotyping fluorescence in situ hybridization reliable methods for identifying chromosomal contents. However, technical issues associated with these can decrease efficiency limit studies that require rapid identification target mice. To overcome limitations, we...
Klinefelter syndrome (KS) is one of the most frequent genetic abnormalities and leading cause nonobstructive azoospermia. The breeding study KS mouse models are essential to advancing our knowledge underlying pathological mechanism. Karyotyping fluorescence in situ hybridization reliable methods for identifying chromosomal contents. However, technical issues associated with these can decrease efficiency limit studies that require rapid identification target mice. To overcome limitations, we...