A5052083382- Hormonal Regulation and Hypertension
- RNA modifications and cancer
- Genetic Associations and Epidemiology
- Cancer-related gene regulation
- Folate and B Vitamins Research
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- Industrial Automation and Control Systems
- Alcohol Consumption and Health Effects
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Circular RNAs in diseases
- Congenital Heart Disease Studies
- Heavy Metal Exposure and Toxicity
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Glycosylation and Glycoproteins Research
- Biomarkers in Disease Mechanisms
- Cannabis and Cannabinoid Research
- Growth Hormone and Insulin-like Growth Factors
- Digestive system and related health
- Aluminum toxicity and tolerance in plants and animals
- Land Use and Ecosystem Services
- Bone Metabolism and Diseases
- Industrial Technology and Control Systems
China Agricultural University
2025
Shaanxi Yanchang Petroleum (China)
2024
State Key Laboratory of Cardiovascular Disease
2024
Qinghai No.3 People's Hospital
2024
Fu Wai Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Fudan University
2018-2023
State Key Laboratory of Medical Neurobiology
2023
Taian City Central Hospital
2016-2021
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2021
Altered abundance or activity of the dual-function transient receptor potential melastatin-like 7 (TRPM7) protein is implicated in neurodegenerative disorders, including Alzheimer’s disease (AD). Toxic aggregation amyloid-β (Aβ) neurons AD pathology. Here, we found that kinase TRPM7 important to stimulate degradation Aβ. expression was decreased hippocampal tissue samples from patients with and two mouse models ( APP/PS1 5XFAD ). In cultures mice, overexpression full-length its functional...
Research on regulation and its mechanism of bone marrow mesenchymal stem cells (BMSCs) dendritic (DCs), which is the initiating factor in immune response has applicable clinical value. Although BMSCs have a significant regulatory effect maturation DCs, molecular still unclear. were co-cultured by different concentration ratios. Flow cytometry was used to detect expression DC markers (CD83, CD11c). Quantitative reverse transcription PCR (qRT-PCR) measure related genes RNA level. Expression...
Although studies provide insights into the neurobiology of stress and depression, exact molecular mechanisms underlying their pathologies remain largely unknown. Long non-coding RNA (lncRNA) has been implicated in brain functions behavior. A potential link between lncRNA psychiatric disorders proposed. However, it remains undetermined whether IncRNA regulation, brain, contributes to or depression pathologies. In this study, we used a valid animal model depression-like symptoms; namely...
Abstract Silica nanoparticles (SiNPs) as one of the most productive nano‐powder, has been extensively applied in various fields. There increasing concern about adverse effects SiNPs on health ecological organisms and human. The potential cardiovascular toxicity involved mechanisms remain elusive. Hence, this study, we investigated (60 nm) explored underlying using H9c2 cardiomyocytes. Results showed that induced oxidative stress activated Nrf2/HO‐1 antioxidant pathway. Autophagy was also by...
We examined the effect of polymorphisms in endothelial nitric oxide synthase gene on risk for essential hypertension a Han Chinese population through meta-analysis data from 15 studies.Associations between increased and 4b/a were obtained dominant model allele contrast (aa + ab vs bb: odds ratio (OR) FE = 1.26, 95% confidence interval (CI) 1.10-1.44;a b allele: OR 1.23, 95%CI: 1.09-1.40).Four studies with sample sizes over 500 produced similar results.No evidence publication bias was...
The etiology of lumbocrural pain is tightly concerned with intervertebral disk degeneration (IDD). Bone mesenchymal stem cell (BMSC)-based therapy bears potentials for IDD treatment. properties microRNA (miRNA)-modified BMSCs may be altered. This study investigated the role and mechanism promoting extracellular matrix (ECM) remodeling degenerated nucleus pulposus cells (NPCs) via miR-101-3p/EIF4G2 axis. NPCs were collected from patients lumbar vertebral fracture (LVF). expressions miR-101-3p...
The aim of this study was to investigate the effects GCKR polymorphism on prevalence overweight and obesity in Chinese female subjects using a gene-wide tagging- single nucleotide (tSNP) strategy. We conducted genetic association Taizhou Retiree Women Cohort, sub-cohort longitudinal study. genotyped four tSNPs (rs4425043, rs780094, rs814295, rs8179206) gene Taqman assay 2,851 investigated their associations with obesity. Odds ratios 95% confidence intervals (CIs) were derived from ordered...
Recently, two polymorphisms (rs1884052 and rs3778099) of estrogen receptor alpha (ER-alpha) gene were identified as being associated with primary quantitative bone mineral density (BMD) in a genome-wide association (GWA) study Framingham cohorts. In this we aimed at investigating the rs1884052 rs3778099, another polymorphism (rs2234693) located intron 1 ER-alpha BMD, body mass index (BMI), glucose, triglyceride, total cholesterol (CHO) levels Chinese Hans. We recruited 425 consecutive adult...
Global nonvalvular AF rises, impacting health severely. In Qinghai, China's diverse setting, studying among varied ethnic groups is crucial OBJECTIVES: The purpose of this study was to compares cardiac features in Tibetan, Han, and Hui patients develop tailored prevention treatment strategies for region, the goal enhance understanding provide an empirical basis developing specific region METHODS: This included a total 3445 diagnosed with atrial fibrillation treated at Qinghai Cardiovascular...
Abstract Background The hypoplastic aortic arch syndrome was defined as a combination of and complex proximal descending anomalies (such aneurysm, coarctation, tortuosity, or dissection). In this study, we proposed novel 'double arch' technique simple surgical procedure to treat the syndrome, which could eliminate requirement for cardiopulmonary bypass. Purpose This study aimed investigate outcomes patients who underwent technique, further evaluate effectiveness safety technique. Methods...
Objective To investigate whether polymorphisms in CYP11B2 gene are associated with nonfamilial structural atrial fibrillation(AF) Chinese Han population. Methods A free-designed pair-matched hospital based ease-control study was performed 297 cases and controls. We investigated two tagging single nucleotide (tSNPs)-rs4545, rs3802228 by using GenomeLabTM SNPstream technique. Results Two tSNPs were consistent Hardy-Weinberg expectations case control groups. Compared controls, the left diameter...
Objective To investigate whether the WNK lysine deficient protein kinase 4 （WNK4） gene C1155547T polymorphism is associated with essential hypertension （EH） in Xinjiang Kazakhs and to assess effect of interaction between this environment factors on EH. Methods The studycovered 556 patients 341 normotensive controls. was determined by Taqman probe real-time PCR method. Some biochemical index such as glucose, triglyceride total cholesterol were also measured. All these results analyzed...