A5031023358- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Vascular Procedures and Complications
- Cardiovascular Function and Risk Factors
- Cerebrovascular and Carotid Artery Diseases
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Health and Disease Prevention
- Cardiac Valve Diseases and Treatments
- Aortic aneurysm repair treatments
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Disease and Adiposity
- Lipoproteins and Cardiovascular Health
- RNA modifications and cancer
- Central Venous Catheters and Hemodialysis
- Cardiac Arrhythmias and Treatments
- Peripheral Artery Disease Management
- Fluid Dynamics and Turbulent Flows
- Cardiac tumors and thrombi
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Bladder and Urothelial Cancer Treatments
- Elasticity and Material Modeling
- Kawasaki Disease and Coronary Complications
Qilu Hospital of Shandong University
2015-2024
Fu Wai Hospital
2010-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Peking Union Medical College Hospital
2017-2024
Weatherford College
2024
Academy of Medical Sciences
2024
State Key Laboratory of Cardiovascular Disease
2021
Dezhou University
2017-2018
Academia Sinica
2008
The aberrant expression of fat mass and obesity-associated protein (FTO) has been confirmed to be associated with a variety cancers participates in the regulation multiple biological behaviours. FTO plays an oncogenic role bladder cancer, but few studies have focused on how promotes cancer progression by regulating miRNA synthesis. Here, we that was significantly increased poor prognosis. overexpression promoted cell proliferation, whereas knockdown inhibited proliferation. We also...
Abstract Background The 2016 guidelines for left ventricular diastolic dysfunction diagnosis has been simplified from previous versions; however, multiparametric approach still exists indeterminate category. Left atrial (LA) strain was recently found useful to predict elevated (LV) filling pressures noninvasively. This study aimed (1) analyze the diagnostic value of LA noninvasive assessment LV in patients with stable coronary artery disease (CAD) preserved ejection fraction (LVEF), using...
Background: With distal transradial access (dTRA), the postoperative compression time remains significantly longer than recommended range via in practice. This study investigated whether intravenous protamine sulfate might shorten and increase safety after coronary angiography dTRA. Methods: In this retrospective study, patients who underwent were enrolled divided into two groups. The group received a slow injection of 15–20 mg before sheath retraction. primary endpoint was puncture...
To assess the association and predictive value of plasma homocysteine (Hcy) levels with LA/LAA thrombus in non-valvular Atrial fibrillation (AF) patients low CHA2DS2-VASc score.Eight hundred eighty-eight consecutive AF score 0 1 were enrolled. All routinely underwent transthoracic echocardiography transoesophageal echocardiography. A total thirty-two had thrombus. Compared without thrombus, Hcy significantly higher (16.5 ± 4.8 mmol/L vs. 13.4 4.1 mmol/L, P = 0.009). In multivariate analysis,...
Radial artery occlusion (RAO) is an unresolved complication after transradial (TRA) puncture. The aim of this observational study was to assess the feasibility and safety retrograde recanalization RAO through distal access (dTRA).From June 2021 March 2022, 28 consecutive patients with successful puncture intubation dTRA in anatomical snuffbox confirmed by angiography were enrolled.Among patients, 27 (96.4%) successfully retrogradely recanalized underwent coronary or intervention. After...
This study aimed to evaluate the association of lipoprotein(a) levels with platelet aggregation and thrombogenicity in patients undergoing percutaneous coronary intervention (PCI), investigate ischemic outcome on this population. Lipoprotein(a) modified thrombelastography were measured 6601 consecutive underwent PCI dual antiplatelet therapy. Cox proportional regression analysis was applied illustrate events a 2-year follow up. The mean 29.0 mg/dl. Patients higher had significantly...
Background. Compliance mismatch is a negative factor and it needs to be considered in arterial bypass grafting. Objective. A computational model was employed investigate the effects of compliance on blood flow, wall stress, deformation. Methods. The unsteady flow assumed laminar, Newtonian, viscous, incompressible. vessel linear elastic, isotropic, fluid-wall interaction scheme constructed using finite element method. Results. results show that there are identical shear stress waveforms,...
The impact of fibrinolysis-first strategy on outcomes patients with ST-segment-elevation myocardial infarction (STEMI) during the COVID-19 pandemic was unknown.Data from STEMI presenting to Fuwai Hospital January 23 April 30, 2020 were compared those equivalent period in 2019. primary end-point net adverse clinical events (NACE; a composite death, non-fatal reinfarction, stroke, emergency revascularization, and bleeding over BARC type 3). secondary outcome recurrent ischaemia, cardiogenic...
Elevated homocysteine (Hcy) has been reported to be associated with cardiovascular events in atrial fibrillation (AF) patients, while the age-related expression pattern of plasma Hcy AF remains unknown. The study was aimed investigate effect advanced age on levels and its association ischemic stroke non-valvular patients.A total 2562 consecutive patients 535 controls were enrolled divided into six groups. Plasma analyzed among different groups, investigated.Plasma did not show any difference...
Background: Prior studies have reported controversial conclusions regarding the risk of adverse cardiovascular events in patients using proton-pump inhibitors (PPIs) combined with clopidogrel therapy, causing much uncertainty clinical practice. We sought to evaluate safety PPIs use among high-risk who underwent percutaneous coronary intervention (PCI) a long-term follow-up study. Methods: A total 7868 consecutive had undergone PCI and received dual antiplatelet therapy (DAPT) at single...
Abstract Background Aslanger’s pattern in electrocardiogram (ECG) indicates that patients may have acute inferior myocardial infarction(AMI) with concomitant critical stenoses on other coronary arteries, which needs to be evaluated the timing of revascularization as risk equivalents ST elevation infarction(STEMI). Case Presentation The patient was a 62-year-old male chief complaint intermittent exertional subxiphoid pain for 20 days from 30th June. One day after last episode (19th July),...
Aim: To investigate the impact of diabetic status on 2-year clinical outcomes in Chinese patients undergoing contemporary percutaneous coronary intervention (PCI) treatment. Methods and Results: A total 10 724 consecutive underwent PCI at Fu Wai Hospital were prospectively collected. Two-year compared between with without diabetes mellitus (DM). Diabetic had more baseline risks extensive disease. During follow-up, rates all-cause death, myocardial infarction (MI), revascularization, major...
Background and Aims. The distal transradial access (dTRA) is a new puncture site for coronary catheterization. We sought to evaluate the feasibility, safety, complication rates of using dTRA cardiac catheterization in Chinese patients. Methods. A total 263 consecutive patients who underwent through were enrolled. primary endpoint study was rate conversion another due impossibility successful artery or intubation. Secondary safety endpoints bleeding-related complications nerve disorders....
To assess long-term survival and late cardiovascular events in patients with atrial myxoma after surgical intervention.Retrospective analysis of 403 undergoing resection from January 2002 to December 2016 was conducted a median follow-up period 4.5 (range: 0.5-15) years.The cross-clamp time cardiopulmonary bypass times were 41.1 ± 21.4 65.2 27.3 min, respectively. A diagnosis histopathologically confirmed all cases. The early in-hospital mortality rate 0.7% (n = 3). During the period, tumor...
Aims. This study sought to report the 10-year clinical outcomes of patients who underwent unprotected left main (LM) percutaneous coronary intervention (PCI) in a large centre. Methods and Results. A total 913 consecutive LM PCI from January 2004 December 2008 at Fu Wai Hospital were retrospectively analysed; mean age was 60.0 ± 10.9 years, females accounted for 22% patients, diabetes present 27.7% an bifurcation lesion occurred 82.9% patients. During median follow-up 9.7 major adverse...
Background Hyperuricemia has recently been identified as a risk factor of cardiovascular diseases; however, prognostic value hyperuricemia in patients with ST-segment elevation myocardial infarction (STEMI) remained unclear. Simultaneously, the mechanism this possible relationship not clarified. At present, some views believe that may be related to inflammatory response. Our study aimed investigate association between and long-term poor prognosis inflammation STEMI undergoing percutaneous...
Objectives To investigate the expression of amyloid precursor protein in bladder cancer, and to study its role malignant cancer cell behaviors. Methods Immunohistochemistry western blotting analysis were used detect level tissues lines. The effect on proliferation, migration, invasion cycle was evaluated by using small interfering ribonucleic acid. levels RAS, RAF, MEK, phosphorylated extracellular regulated kinases, kinase B determined blot after knockdown. kinases pathway further agonist,...