A5066497533- BRCA gene mutations in cancer
- Ovarian cancer diagnosis and treatment
- Genetic Associations and Epidemiology
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Immune Cell Function and Interaction
- Colorectal Cancer Screening and Detection
- Epigenetics and DNA Methylation
- T-cell and B-cell Immunology
- Global Cancer Incidence and Screening
- Diabetes and associated disorders
- Metastasis and carcinoma case studies
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- AI in cancer detection
- Cancer-related gene regulation
- Genomic variations and chromosomal abnormalities
- Prostate Cancer Treatment and Research
- Genomics and Rare Diseases
- HIV Research and Treatment
- RNA modifications and cancer
- Nutrition, Genetics, and Disease
- Breast Cancer Treatment Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Digital Radiography and Breast Imaging
University of Cambridge
2014-2025
University of Alabama
2017-2025
First Affiliated Hospital of Sichuan Medical University
2024
Southwest Medical University
2024
Sun Yat-sen University
2024
Sun Yat-sen University Cancer Center
2024
Shenzhen University
2024
MRC Epidemiology Unit
2020-2024
Affiliated Hospital of Southwest Medical University
2024
Shenyang The Fourth Hospital of People
2023
Stratification of women according to their risk breast cancer based on polygenic scores (PRSs) could improve screening and prevention strategies. Our aim was develop PRSs, optimized for prediction estrogen receptor (ER)-specific disease, from the largest available genome-wide association dataset empirically validate PRSs in prospective studies. The development comprised 94,075 case subjects 75,017 control European ancestry 69 studies, divided into training validation sets. Samples were...
PURPOSE To estimate age-specific relative and absolute cancer risks of breast to ovarian, pancreatic, male breast, prostate, colorectal cancers associated with germline PALB2 pathogenic variants (PVs) because these have not been extensively characterized. METHODS We analyzed data from 524 families PVs 21 countries. Complex segregation analysis was used (RRs; country-specific population incidences) cancers. The models allowed for residual familial aggregation ovarian were adjusted the...
To provide precise age-specific risk estimates of cancers other than female breast and ovarian associated with pathogenic variants (PVs) in
The purpose of this study was to estimate precise age-specific tubo-ovarian carcinoma (TOC) and breast cancer (BC) risks for carriers pathogenic variants in RAD51C RAD51D.
Background The multifactorial Breast and Ovarian Analysis of Disease Incidence Carrier Estimation Algorithm (BOADICEA) breast cancer risk prediction model has been recently extended to consider all established factors. We assessed the clinical validity in a large independent prospective cohort. Methods validated BOADICEA (V.6) Swedish KARolinska Mammography Project for Risk Prediction Cancer (KARMA) cohort including 66 415 women European ancestry (median age 54 years, IQR 45–63; 816 incident...
Polygenic risk scores (PRS) for epithelial ovarian cancer (EOC) have the potential to improve stratification. Joint estimation of Single Nucleotide Polymorphism (SNP) effects in models could predictive performance over standard approaches PRS construction. Here, we implemented computationally efficient, penalized, logistic regression (lasso, elastic net, stepwise) individual level genotype data and a Bayesian framework with continuous shrinkage, "select shrink summary statistics" (S4),...
To quantify the contributions of polygenic scores, primary care records (presenting symptoms, medical history and common blood tests) lifestyle factors, for short-term risk prediction colorectal cancer (CRC) in general symptomatic individuals. This prospective cohort study used data from UK Biobank with follow-up until 2018. It included 160 507 participants linked a subcohort 42 782 recent CRC-related symptoms. The outcome was first-recorded CRC diagnosis within 2 years. Dynamic models...
Identification of alterations in the cellular composition human immune system is key to understanding autoimmune process. Recently, a subset FOXP3+ cells with low CD25 expression was found be increased peripheral blood from systemic lupus erythematosus (SLE) patients, although its functional significance remains controversial. Here we find comparisons healthy donors that frequency within CD127lowCD25low CD4+ T (here defined as CD25lowFOXP3+ cells) patients affected by disease varying...
Regulatory T cells (Tregs) expressing FOXP3 are essential for the maintenance of self-tolerance and deficient in many common autoimmune diseases. Immune tolerance is maintained part by IL-2 deficiencies pathway cause reduced Treg function an increased risk autoimmunity. Recent studies expanding Tregs vivo with low-dose achieved major clinical successes highlighting potential to optimize this pleiotropic cytokine inflammatory disease indications. Here we compare clinically approved molecule,...
Epithelial tubo-ovarian cancer (EOC) has high mortality partly due to late diagnosis. Prevention is available but may be associated with adverse effects. A multifactorial risk model based on known genetic and epidemiological factors (RFs) for EOC can help identify women at higher who could benefit from targeted screening prevention.
Background Genome-wide association studies have identified >30 common SNPs associated with epithelial ovarian cancer (EOC). We evaluated the combined effects of EOC susceptibility on predicting risk in an independent prospective cohort study. Methods genotyped single nucleotide polymorphisms (SNPs) a nested case–control study (750 cases and 1428 controls) from UK Collaborative Trial Ovarian Cancer Screening trial. Polygenic scores (PRSs) were constructed their associations using logistic...
Purpose: To establish a clinically applicable genomic clustering system, we investigated the interactive landscape of driver mutations in intrahepatic cholangiocarcinoma (ICC). Methods: The data 1481 ICCs from diverse populations was analyzed to investigate pair-wise co-occurrences or mutual exclusivities among recurrent mutations. Clinicopathological features and outcomes were compared different clusters. Gene expression DNA methylation profiling datasets molecular distinctions mutational...
Background BOADICEA (v7) predicts future breast cancer (BC) risk using data on family history, genetic markers, questionnaire-based factors and mammographic density (MD) measured the 4-category BI-RADS classification. However, requires manual reading, which is impractical a large scale may cause information loss. Methods We extended to incorporate continuous MD measurements, calculated automated Volpara STRATUS software. used from KARMA cohort (60,276 participants; 1,167 incident BC)....
Recent population-based female breast cancer and prostate polygenic risk scores (PRS) have been developed. We assessed the associations of these PRS with risks for male BRCA1 BRCA2 pathogenic variant carriers.
Prostate cancer (PCa) is highly heritable. No validated PCa risk model currently exists. We therefore sought to develop a genetic that can provide personalized predicted risks on the basis of known moderate- high-risk pathogenic variants, low-risk common and explicit family history, externally validate in an independent prospective cohort.
Deleterious germline variants in
Purpose: The purpose of this study was to evaluate the effectiveness community health worker (CHW) training support adults with hearing loss who are living in rural communities West Central and South Alabama. Knowledge skills, addition degree confidence performing tasks associated aural rehabilitation program, were assessed. Method: Eighteen active their through nonprofit organizations, educational facilities, or had other volunteering experiences, participated study. They received 3 days...
Abstract Breast cancer risk prediction models use a range of predictors to estimate an individual’s chance developing breast in given timeframe. These can facilitate stratification, identify individuals who would benefit most from screening or preventive options. The BOADICEA model, implemented the CanRisk tool (www.canrisk.org), uses genetic, lifestyle, hormonal, family history and anthropometric data risk. When implementing models, predictor are often incomplete. Point-estimates calculated...
To evaluate the therapeutic effects of a probiotic supplement (Clostridium butyricum, CGMCC0313) in chemically-induced rat model experimental colitis.An ulcerative colitis was established by rectal injection oxazolone into colon 40 Wistar rats randomly divided four groups. The positive control group sacrificed 3 d after onset. remaining groups were fed daily with either 2 mL C. butyricum (2.3 x 10(11) CFU/L), mesalamine (100 g/L), or 1 sodium butyrate (50 mmol/L) for 21 d. animals' body...
The aim of this study was to compare and externally validate risk scores developed predict incident colorectal cancer that include common genetic variants (SNPs), with or without established lifestyle/environmental (questionnaire-based/classical/phenotypic) factors. We validated 23 models from a previous systematic review in 443,888 participants ages 37 73 the UK Biobank cohort who had 6-year prospective follow-up, no prior history cancer, data for incidence through linkage national...
// Donghui Zhang 1 , Enqin Liu Jian Kang 2 Xin Yang 3 and Hong Department of Infectious Disease, Linyi People’s Hospital, 276000, China Colorectal Surgery, Tai’an City Central 271000, Culverhouse College Commerce Business Administration, The University Alabama, Tuscaloosa, AL 35401, USA Correspondence to: Liu, email: wlb4eo@163.com Keywords: cell cycle, proliferation, hepatocellular carcinoma, hsa-miR-3613-3p Received: May 04, 2017 Accepted: August...
Unselected population-based personalised ovarian cancer (OC) risk assessment combining genetic/epidemiology/hormonal data has not previously been undertaken. We aimed to perform a feasibility study of OC stratification general population women using tool followed by management. Volunteers were recruited through London primary care networks. Inclusion criteria: ≥18 years. Exclusion prior ovarian/tubal/peritoneal cancer, previous genetic testing for genes. Participants accessed an...
Optimal treatment strategy for severe fever with thrombocytopenia syndrome (SFTS) remained unknown. We aimed to evaluate the efficacy of intravenous immunoglobulin (IVIG) on SFTS.