A5034148675- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Renal cell carcinoma treatment
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- BRCA gene mutations in cancer
- Ferroptosis and cancer prognosis
- Extracellular vesicles in disease
- Viral Infections and Vectors
- Cancer Immunotherapy and Biomarkers
- Renal and related cancers
- Cancer Genomics and Diagnostics
- PARP inhibition in cancer therapy
- DNA Repair Mechanisms
- Genetic Neurodegenerative Diseases
- Prostate Cancer Treatment and Research
- COVID-19 Clinical Research Studies
- Helicobacter pylori-related gastroenterology studies
- Parkinson's Disease Mechanisms and Treatments
- Digestive system and related health
- Cancer-related Molecular Pathways
- Sperm and Testicular Function
- Genetic factors in colorectal cancer
- IL-33, ST2, and ILC Pathways
- Neurological disorders and treatments
Bashkir State Medical University
2003-2024
Ufa Institute of Chemistry
2019-2024
St Petersburg University
2022-2024
Ministry of Health of the Russian Federation
2018-2024
Institute of Biochemistry and Genetics of Ufa Scientific Centre
2003-2023
Russian Academy of Sciences
2003-2023
Jilin University
2021
Bashkir State University
2015-2018
Stratification of women according to their risk breast cancer based on polygenic scores (PRSs) could improve screening and prevention strategies. Our aim was develop PRSs, optimized for prediction estrogen receptor (ER)-specific disease, from the largest available genome-wide association dataset empirically validate PRSs in prospective studies. The development comprised 94,075 case subjects 75,017 control European ancestry 69 studies, divided into training validation sets. Samples were...
Evidence continues to accrue implicating mitochondrial dysfunction in the etiology of a number neurodegenerative diseases. For example, Parkinson's disease (PD) can be induced by toxins, and nuclear DNA (nDNA) loci linked PD have been associated with dysfunction. Although conclusions about role (mtDNA) variants vary, we argue here that this is attributable novel genetics mtDNA fact clinically relevant variation encompasses ancient adaptive polymorphisms, recent deleterious mutations, somatic...
Immunotherapy with immune checkpoint inhibitors (ICIs) has shown high efficiency in clear cell renal carcinoma (ccRCC) treatment. However, the response to therapy among patients varies greatly. Modern studies demonstrate potential of exosomal miRNAs as diagnostic and prognostic markers oncopathology. This study aimed evaluate miRNA expression profiles miRNAs-144, -146a, -149, -126, -155 treated inhibitors. The included 35 whose venous blood samples were taken before after ICI therapy....
For several decades, most lung cancer investigations have focused on the search for mutations in candidate genes; however, last decade, due to fact that of human genome is occupied by sequences do not code proteins, much attention has been paid non-coding RNAs (ncRNAs) perform regulatory functions. In this review, we principally recent studies function, mechanisms, and therapeutic potential ncRNAs including microRNA (miRNA), long ncRNA (lncRNA), circular RNA (circRNA) different types cancer.
Epidemiological data highlight prostate cancer as a significant global health issue, with high incidence and substantial impact on patients' quality of life. The prevalence this disease is associated various factors, including age, heredity, race. Recent research in genetics has identified several genetic variants that may be an increased risk developing the disease. However, despite significance these findings, markers for are not currently utilized clinical practice reliable...
Background COVID-19 disease has infected more than 772 million people, leading to 7 deaths. Although the severe course of can be prevented using appropriate treatments, effective interventions require a thorough research genetic factors involved in its pathogenesis. Methods We conducted genome-wide association study (GWAS) on 7,124 individuals (comprising 6,400 controls who had mild moderate and 724 cases with COVID-19). The inclusion criteria were acute respiratory distress syndrome (ARDS),...
Clear cell renal carcinoma (ccRCC) is characterized by high molecular genetic heterogeneity, metastatic activity and unfavorable prognosis. MicroRNAs (miRNA) are 22-nucleotide noncoding RNAs that aberrantly expressed in cancer cells have gained serious consideration as non-invasive biomarkers. We investigated possible differential miRNA signatures may differentiate high-grade ccRCC from primary disease stages. High-throughput miRNAs expression profiling, using TaqMan OpenArray Human MicroRNA...
Prostate cancer (PCa) is one of the most common types among men. To date, there have been no specific markers identified for diagnosis and prognosis or response to treatment this disease. Thus, an urgent need promising markers, which may be fulfilled by small non-coding RNAs known as microRNAs (miRNAs). Therefore, present study aimed investigate miRNA profile in tissue samples obtained from patients with PCa using microarrays, followed reverse transcriptase quantitative PCRs (RT-qPCRs). In...
Renal cell carcinoma represents 3% of all adult malignancies. MicroRNAs exhibit specific functions in various biological processes through their interaction with cellular mRNA involved apoptosis and cycle control. Recent studies have reported the potential association single-nucleotide polymorphisms (SNPs) miRNA-binding sites VHL-HIF1α pathway genes renal cancer development progression.
Prostate cancer (PC) is one of the most frequently diagnosed cancers in males. MiR-153, as a member microRNA (miRNA) family, plays an important role PC. This study aims to explore expression and possible molecular mechanisms miR-153 action. Formalin-fixed paraffin-embedded (FFPE) tissues were collected from prostatectomy specimens 29 metastatic 32 initial stage PC patients. Expression levels measured using real-time reverse transcription polymerase chain reaction (qRT-PCR). 2−ΔΔCT method was...
Hemorrhagic fever with renal syndrome (HFRS), caused by Orthohantaviruses, occupies one of the leading places among natural focal human diseases, for which there are no modern accurate and highly sensitive diagnostic methods. To improve this situation, a better understanding Hantavirus pathogenesis HFRS is required. Determination expression level exosomal microRNAs (miRNAs) in serum/plasma patients makes them potential biomarkers diagnosing predicting HFRS. The purpose study was to analyze...
To reveal the association of interleukin 8 (IL-8) gene with development and progression oral lichen planus (OLP) we performed RT-PCR analysis rs4073 polymorphism in IL-8 92 patients 163 healthy individuals Russian ethnic origin from Volga-Ural region Russia. The investigation showed importance for development. disease was associated genotype rs4073*T / T which found to be genetic marker high risk development, rs4073*A — low erosive-ulcerous form (p=0.016, OR=0.40) recurrence (p=0.02,...