A5036847956- Asthma and respiratory diseases
- Human Health and Disease
- IL-33, ST2, and ILC Pathways
- Chemical Reactions and Isotopes
- Pediatric health and respiratory diseases
- Nutrition, Genetics, and Disease
- Helicobacter pylori-related gastroenterology studies
- Allergic Rhinitis and Sensitization
- Digestive system and related health
- Dermatology and Skin Diseases
- Chronic Myeloid Leukemia Treatments
- Trace Elements in Health
- MicroRNA in disease regulation
- Medical and Biological Sciences
- Glutathione Transferases and Polymorphisms
- Immune Cell Function and Interaction
- Mast cells and histamine
- Aluminum toxicity and tolerance in plants and animals
- Heavy Metal Exposure and Toxicity
- COVID-19 Clinical Research Studies
- Tuberculosis Research and Epidemiology
- Long-Term Effects of COVID-19
- Genetic Associations and Epidemiology
- Yersinia bacterium, plague, ectoparasites research
- Chemical and Physical Studies
Ufa Institute of Chemistry
2018-2024
Russian Academy of Sciences
2000-2024
Bashkir State Medical University
2021-2024
St Petersburg University
2024
Institute of Biochemistry and Genetics of Ufa Scientific Centre
2006-2020
Bashkir State University
2014-2020
Clear cell renal carcinoma (ccRCC) is characterized by high molecular genetic heterogeneity, metastatic activity and unfavorable prognosis. MicroRNAs (miRNA) are 22-nucleotide noncoding RNAs that aberrantly expressed in cancer cells have gained serious consideration as non-invasive biomarkers. We investigated possible differential miRNA signatures may differentiate high-grade ccRCC from primary disease stages. High-throughput miRNAs expression profiling, using TaqMan OpenArray Human MicroRNA...
To date, multiple efforts have been made to use genome-wide association studies (GWAS) untangle the genetic basis for SARS-CoV-2 infection susceptibility and severe COVID-19. However, data on genetic-related effects of presence accompanying long-term post-COVID-19 neurological symptoms in younger individuals remain absent. We aimed examine possible between SNPs found a GWAS COVID-19 outcomes three phenotypes: infection, complications during disease progression, young adults with...
We have analyzed the distribution and patterns of genetic diversity eight Alu loci (ACE, ApoA1, PV92, TPA25, NBC27, NBC102, NBC148, NBC182) in 1,049 individuals representing 16 populations Volga-Ural region (Bashkirs, Tatars, Komis, Maris, Mordvins, Udmurts), Central Asia (Kazakhs, Uzbeks, Uighurs), North Caucasus (Karachays, Kumyks, Kuban Nogays, Karanogays), South Siberia (Yakuts, Kalmyks Evenks). Geographic divide between Europe Asia, e.g. Ural Mountains Caspian Sea, can also be...
Summary. Asthma is one of the most common, severe and debilitating multifactorial diseases resulting from complex interaction between genes environ mental factors. The aim present work was to analyze association cytokine gene polymorphisms development asthma in population Republic Bashkortostan. A total 638 patients with 366 healthy individuals were recruited our investigation. In summary, study genegene suggested an important role TNFA, IL4, CCL11 IL13 genepolymorphisms Bashkortostan population.
Asthma is a common severe disease of the respiratory tract, it leads to significant impairment in quality patient's life unless effectively treated. Uncontrolled asthma symptoms are cause progression and development, they lead an increase disability. The sensitivity therapy largely depends on interaction genetic epigenetic factors, which account for about 50–60 % variability therapeutic response. Beta-2-agonists some major class bronchodilators used management. According published data,...
Asthma is a common complex disease with susceptibility defined through an interplay of genetic and environmental factors. Responsiveness to asthma treatment varies between individuals largely determined by variability. The polygenic score (PGS) approach enables individual risk respective response drug therapy. PGS models could help predict the using 26 SNPs pathway genes involved in metabolism glucocorticosteroids (GCS), beta-2-agonists, antihistamines, antileukotriene drugs associated...
Бронхиальная астма (БА) - гетерогенное хроническое воспалительное заболевание дыхательных путей, которое при недостаточно эффективном лечении может значительно снижать качество жизни пациентов. Эффективность лекарственной терапии, оптимальный класс и режим дозирования препарата во многом определяются генетическими эпигенетическими факторами, которые необходимо учитывать определении тактики лечения больного. В последние годы достигнут значительный прогресс в области фармакогенетики БА как...