A5087785256- Genetic Associations and Epidemiology
- Nutrition, Genetics, and Disease
- Birth, Development, and Health
- Tryptophan and brain disorders
- PARP inhibition in cancer therapy
- Digestive system and related health
- Mental Health Research Topics
- Diet, Metabolism, and Disease
- Cardiovascular Disease and Adiposity
- COVID-19 Clinical Research Studies
- Inflammasome and immune disorders
BACKGROUND: Anhedonia is characterized by a reduced ability to anticipate, experience, and/or learn about pleasure. This phenomenon has transdiagnostic nature and one of the key symptoms mood disorders, schizophrenia, addictions, somatic conditions. AIM: To evaluate genetic architecture anhedonia its overlap with other mental disorders METHODS: We performed genome-wide association study on sample 4,520 individuals from Russian non-clinical population. Using available summary statistics, we...
Background COVID-19 disease has infected more than 772 million people, leading to 7 deaths. Although the severe course of can be prevented using appropriate treatments, effective interventions require a thorough research genetic factors involved in its pathogenesis. Methods We conducted genome-wide association study (GWAS) on 7,124 individuals (comprising 6,400 controls who had mild moderate and 724 cases with COVID-19). The inclusion criteria were acute respiratory distress syndrome (ARDS),...
To conduct an exploratory Mendelian randomization analysis of the causal relationships anhedonia with a wide range psychiatric and somatic phenotypes based on genetic data participants in population study.This cross-sectional study included 4520 participants, which 50.4% (n=2280) were female. The mean age was 36.8 (S.D.=9.8) years. Participants pheno-nailed DSM-5 criteria for framework depression. An episode exceeding 2 weeks during life reported by 57.6% (n=2604) participants. A genome-wide...