A5101820103- Cancer-related molecular mechanisms research
- PI3K/AKT/mTOR signaling in cancer
- Glycosylation and Glycoproteins Research
- Plant and Fungal Species Descriptions
- Ecology and Conservation Studies
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Plant Diversity and Evolution
- Diet and metabolism studies
- Gastric Cancer Management and Outcomes
- Birth, Development, and Health
- Traditional Chinese Medicine Analysis
- Plant tissue culture and regeneration
- Epigenetics and DNA Methylation
- Studies on Chitinases and Chitosanases
- Cancer Cells and Metastasis
- Plant Molecular Biology Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- HIV/AIDS Research and Interventions
- Botanical Studies and Applications
- Lung Cancer Treatments and Mutations
- Medical Imaging and Pathology Studies
- Brucella: diagnosis, epidemiology, treatment
- Glutathione Transferases and Polymorphisms
- Bariatric Surgery and Outcomes
Xian Yang Central Hospital
2025
Southern Medical University
2011-2025
Guangzhou Medical University
2021-2025
Zhujiang Hospital
2023-2025
Guangzhou Eighth People's Hospital
2021-2025
Weifang People's Hospital
2025
Sichuan Center for Disease Control and Prevention
2025
Chinese Center For Disease Control and Prevention
2025
Weifang Medical University
2019-2024
Second Affiliated Hospital of Nanjing Medical University
2023-2024
Bone homeostasis is tightly orchestrated and maintained by the balance between osteoblasts osteoclasts. Recent studies have greatly expanded our understanding of molecular mechanisms cellular differentiation. However, functional roles non-coding RNAs particularly lncRNAs in remodeling bone architecture remain elusive. In study, lncRNA H19 was found to be upregulated during osteogenesis hMSCs. Stable expression significantly accelerated vivo vitro osteoblast Meanwhile, using bioinformatic...
The selection and breeding of good meat rabbit breeds are fundamental to their industrial development, genomic (GS) can employ information make up for the shortcomings traditional phenotype-based methods. For practical implementation GS in breeding, it is necessary assess different marker densities models. Here, we obtained low-coverage whole-genome sequencing (lcWGS) data from 1515 rabbits (including parent herd half-sibling offspring). specific objectives were (1) derive a baseline...
Objective: we compared and analyzed the imaging features, tumor markers, pathological immunohistochemistry, lymph node metastasis rates of solitary multiple lung adenocarcinoma to provide a valuable reference for clinical diagnosis treatment. Methods: A retrospective analysis 212 patients who underwent thoracic surgery in our hospital from 2022 2023, including 149 with nodule 63 primary nodules. Via propensity score matching, serological two groups were compared, differences between nodules...
Introduction Despite expanded antiretroviral therapy (ART) in China, HIV transmission persists. Liangshan Prefecture is one of the areas China most severely affected by HIV, with high levels drug resistance. A deeper understanding HIV-1 resistance can lead to improvements current treatment policies. Methods We conducted an analysis mutations (DRMs) among patients failure and people newly diagnosed Prefecture. 8,523 blood samples were collected from living individuals all 15 counties two...
Liangshan Prefecture is one of the areas in China most severely affected by human immunodeficiency virus (HIV), but little known about molecular epidemiology HIV-1 this area. We aimed to analyze distribution genetic variants recent years. 8,523 blood samples were collected from people living with HIV treatment failure and newly diagnosed individuals all 17 counties cities between 2021 2023. The majority study participants male (66%), farmers (78%) illiterate (53%). main transmission routes...
Hepatocellular carcinoma (HCC), a common malignancy in China and globally, is primarily treated through surgical resection liver transplantation, with chemotherapy as significant synergistic option. Adenine (Ade), nucleobase, exhibits antitumor effects by blocking human hepatic cells S phase inhibiting tumor cell proliferation. However, its use limited owing to low solubility, poor targeting ability, nephrotoxicity. Therefore, liver-targeting drug delivery systems have attracted considerable...
Weighted gene co-expression network analysis (WGCNA) identified a cell-cycle module that is associated with poor prognosis and aggressiveness of glioma. One the core members, Regulator chromatin condensation 2 (RCC2) component chromosome passenger complex. Accumulating evidence suggests RCC2 plays vital role in mitotic process abnormal expression involved cancer development. Gene silencing experiments show required for glioma cell proliferation migration. RNA-Sequencing reveals dual both...
Abstract Background Recently the prevalence of precocious puberty development is increasing among Chinese children. Proper understanding risk factors for in children pivotal as could help to improve children's health. This study aims evaluate effect environmental on Methods We matched cases and controls by age at ratio 1:1 (201 201 controls) girls 1:4 (24 96 boys. used conditional logistic regression explore puberty, a random forest model identify most important factor. Results In...
Glial cell-mediated neuroinflammation and neuronal attrition are highly correlated with cognitive impairment in Alzheimer's disease. YKL-40 is a secreted astrocytic glycoprotein that serves as diagnostic biomarker of High levels associated either advanced disease or the normal aging process. However, functional role development has not been firmly established. In 5xFAD mouse model disease, we observed increased expression cerebrospinal fluid 7-month-old mice was activated astrocytes. primary...
PTEN is a tumor suppressor gene inactivated in over 30% of human cancers. It encodes lipid phosphatase that serves as gatekeeper the phosphoinositide 3‐kinase signaling pathway. Germline mutation frequently occurs this patients diagnosed with Hamartoma Tumor Syndrome (PHTS). PHTS individuals are characterized by macrocephaly, benign growth multiple tissues and increased risk. In addition, autistic phenotypes found 10–20% carrying germline macrocephaly. report, 13 suspected were screened for...
The cilium of a cell translates varied extracellular cues into intracellular signals that control embryonic development and organ function. dynamic maintenance ciliary structure function requires balanced bidirectional cargo transport involving intraflagellar (IFT) complexes. IFT172 is member the IFT complex B, mutation associated with pathologies including short rib thoracic dysplasia, retinitis pigmentosa Bardet-Biedl syndrome, but how it underpins these conditions not clear. We used WIM...
Abstract Background Clonidine stimulation test has been widely used in the diagnosis of growth hormone deficiency children with short stature a high level reliability. However, it may cause hypotension, which usually appears as headache, dizziness, bradycardia, and even syncope. It is well known that elevating beds to make patients’ feet above their cardiac might relieve this discomfort. real efficiency method remains be proved while best angle for elevated bed still unclear. Methods A total...
Germline mutation in the PTEN gene is genetic basis of hamartoma tumor syndrome with affected individuals harboring features autism spectrum disorders. Characterizing a panel 14 autism-associated missense mutations revealed reduced protein stability, catalytic activity, and subcellular distribution. Nine out (64%) mutants had expression most confined to C2 domain. Selected displayed enhanced polyubiquitination shortened half-life, but that did not appear involve sites at lysine residues...