A5017162176- Parasitic Infections and Diagnostics
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Glioma Diagnosis and Treatment
- Insect symbiosis and bacterial influences
- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
Shandong University
2022-2024
Guangzhou Medical University
2022
Weighted gene co-expression network analysis (WGCNA) identified a cell-cycle module that is associated with poor prognosis and aggressiveness of glioma. One the core members, Regulator chromatin condensation 2 (RCC2) component chromosome passenger complex. Accumulating evidence suggests RCC2 plays vital role in mitotic process abnormal expression involved cancer development. Gene silencing experiments show required for glioma cell proliferation migration. RNA-Sequencing reveals dual both...
Microsporidia are intracellular eukaryotic pathogens that pose a substantial threat to immunocompromised hosts. The way these manipulate host cells during infection remains poorly understood. Using proximity biotinylation strategy we established microsporidian EnP1 is nucleus-targeted effector modifies the cell environment. EnP1’s translocation nucleus meditated by nuclear localization signals (NLSs). In nucleus, interacts with histone H2B. This interaction disrupts H2B monoubiquitination...