A5100431064- Cancer-related molecular mechanisms research
- Toxoplasma gondii Research Studies
- Circular RNAs in diseases
- RNA modifications and cancer
- Dental Implant Techniques and Outcomes
- Electrospun Nanofibers in Biomedical Applications
- Nanoparticles: synthesis and applications
- Iron Metabolism and Disorders
- Extracellular vesicles in disease
- Oral microbiology and periodontitis research
- Polymer Surface Interaction Studies
- Mycobacterium research and diagnosis
- Bone Tissue Engineering Materials
- Silk-based biomaterials and applications
- Epigenetics and DNA Methylation
- Antifungal resistance and susceptibility
- Trace Elements in Health
- Dental materials and restorations
- MicroRNA in disease regulation
- Parasitic Infections and Diagnostics
- Bacterial biofilms and quorum sensing
- Plant and Fungal Interactions Research
Qingdao University
2014-2025
Affiliated Hospital of Qingdao University
2020-2025
Shandong University
2020-2024
Jilin Agricultural University
2020-2021
Microsporidia are intracellular eukaryotic pathogens that pose a substantial threat to immunocompromised hosts. The way these manipulate host cells during infection remains poorly understood. Using proximity biotinylation strategy we established microsporidian EnP1 is nucleus-targeted effector modifies the cell environment. EnP1’s translocation nucleus meditated by nuclear localization signals (NLSs). In nucleus, interacts with histone H2B. This interaction disrupts H2B monoubiquitination...
Abstract Current antibacterial sutures for preventing surgical site infections (SSIs) face challenges including suboptimal drug utilization efficiency and uncontrolled burst release. To address these limitations, an conductive suture with electrically controlled release system is developed in this study. Polypyrrole (PPy) doped tannic acid (TA) situ polymerized on the surface of silk precoated chitosan/gelatin (CS/GE), designated as PCG‐SS. The PCG‐SS exhibits excellent conductivity,...
Iron deficiency anemia (IDA) is a common nutritional disease associated with early childhood caries. This study aimed to explore the role of iron levels in pathological changes dental caries childhood. Rats were divided into four groups based on their content: IDA, positive control (PC), high (HI), and negative (NC). Except for rats NC group, other inoculated Streptococcus mutans fed cariogenic high-sugar fodder induce Three months later, status molars was evaluated at both smooth sulcal...
Abstract Background Oral squamous cell carcinoma (OSCC) is a normal form of mouth cancer, comprising the majority oral cancers. A large number long non‐coding RNAs (lncRNAs) have been reported due to their oncogenic function in Recent studies show that lncRNA CCHE1 an oncogene wide range Whether accelerates progression OSCC still undiscovered. Methods The qRT‐PCR analysis was used determine CCHE1, miR‐922, and PAK2 expression levels. CCK8 colony formation assays were applied evaluate...
Though it is well known that chronic infections of Toxoplasma gondii are able to induce mental and behavioral disorders in host, little about the role lncRNA (long noncoding RNA) this pathological process. In study, we employed an advanced lncRNAs mRNAs integration chip (Affymetrix HTA 2.0) detect expression both T. Chinese 1 strain infected mouse brain. As a result, for first time, downregulation lncRNA-11496 (NONMMUGO11496) was identified as responsible factor We showed dysregulation...
Toxoplasma gondii is neurotropic and affects the function of nerve cells, while mechanism unclear. LncRNAs are abundantly enriched in brain participated delicate regulation central nervous system (CNS) development. However, whether these lncRNAs involved microglia activation during process T. infection largely unknown. In this study, upregulation a novel lncRNA147410.3 (ENSMUST00000147410.3) was identified as key factor to influence process. The target gene predicted Hoxb3. localization...