A5050443778- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Heart Rate Variability and Autonomic Control
- Pharmacology and Obesity Treatment
- Liver Disease Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Bone health and osteoporosis research
- Diabetes Management and Research
- Cardiovascular Syncope and Autonomic Disorders
- Chronic Kidney Disease and Diabetes
- Pituitary Gland Disorders and Treatments
- Blood Pressure and Hypertension Studies
- Hormonal Regulation and Hypertension
- Tryptophan and brain disorders
- Regulation of Appetite and Obesity
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Vitamin D Research Studies
- Thyroid Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Pain Mechanisms and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Ophthalmology and Eye Disorders
- Liver Disease and Transplantation
- Hepatitis C virus research
- Pancreatic function and diabetes
Chang Gung University
2013-2024
Kaohsiung Chang Gung Memorial Hospital
2014-2024
Memorial Hospital of South Bend
2004-2012
Elevations in blood pressure and visit-to-visit variability have been found to significantly increase the risk of cardiovascular morbidity mortality nondiabetic individuals. This study has assessed association between all-cause parameters [systolic (SBP), diastolic (DBP), pulse (PP), mean arterial (MAP) variability] patients with type 2 diabetes.A longitudinal cohort 2161 diabetes a follow-up period 66·7 ± 7·5 months. Using Cox regression models, were related mortality.Visit-to-visit SBP...
There is limited clinical information comparing presentations and results of treatment papillary follicular thyroid carcinoma patients with distant metastases. We retrospectively analyzed data 1,257 cancer who received their follow-up at Chang Gung Memorial Hospital. found 992 205 carcinoma. Of these, 68 (6.9%) had metastases the time diagnosis or during period. patients, 69 (33.7%) carcinoma, only 33 were categorized as stage IV diagnosis. Nine I 10 II, 16 III. Sixteen (23.5%) died study...
The aim of this study was to identify the prognostic factors long-term survival and optimal therapeutic protocol for patients with distant metastasis secondary differentiated thyroid carcinoma (DTC). A retrospective review 1665 DTC treated at a regional tertiary hospital in Taiwan between 1986 2010 performed. Among them, 207 were found have metastasis. For outcome survey, 126 that had received least 5 years (mean 9·6 ± 5·2 years) follow-up after diagnosis analysed study. Prognostic factor...
Type 2 diabetes mellitus (T2DM) is significantly associated with osteoarthritis (OA). This study investigated the effects of two resistance exercise approaches on glycated hemoglobin (HbA1c) level and function performance. Enrolled were 70 older patients both T2DM knee OA. The dynamic group performed exercises an elastic band. isometric underwent contraction exercises. After 12-week intervention, a significant within-group improvement (all p < 0.001) was observed for chair stand test...
Variability in the glycated hemoglobin (HbA1c) level is associated with a higher risk of microvascular complications patients type 2 diabetes. We tested hypothesis that HbA1c variability not only strongly presence but also degree severity cardiovascular autonomic neuropathy (CAN) long diabetes durations (more than 10 years).For each patient, intrapersonal mean, standard deviation (SD), and coefficient variation (CV) for were calculated using all measurements obtained 3 years before study....
Klebsiella pneumoniae (KP), with production of abundant capsular polysaccharide (CPS), is capable causing invasive syndrome. Environmental glucose stimuli may increase CPS biosynthesis. We aimed to investigate the relationship between glycemic control and KP-mediated syndrome in diabetic patients effect on Diabetic community-acquired KP bacteremia were included study risk factors KP-M1, a serotype-K1 clinical isolate, was used examine biosynthesis cps gene expression, exogenous bacterial...
Glycemic variability is associated with higher risk of microvascular complications in patients type 2 diabetes.To test the hypothesis that glycemic can contribute to progression macroalbuminuria normal or microalbuminuria diabetes.This prospective study enrolled 193 diabetes at a tertiary medical center.For each patient, intrapersonal (mean, SD, and coefficient variation HbA1c) was calculated using all measurements obtained three years before study. Patients were divided into four groups...
Abstract Objective: A common variant in mitochondrial DNA (mtDNA) at bp 16189 (T→C transition) has been associated with small birth size, adulthood hyperglycemia, and insulin resistance Caucasians. In this study, we investigated whether mtDNA is metabolic syndrome Chinese subjects. Methods: Six hundred fifteen adults, aged 40 yr or older, were recruited study. The of was detected using PCR restriction enzyme digestion. Metabolic diagnosed on modified National Cholesterol Education Program...
The purpose of the present study was to explore relationship between serum lipid and lipoprotein levels clinical subtypes in patients with depressive disorders. A total 207 who were admitted for general health screening assessed by using semistructured interview Diagnostic Statistical Manual Mental Disorders (4th edn; DSM-IV) criteria possibility having Blood physical examinations done rule out systemic diseases. 142 without diseases recruited further analysis, including dysthymia (n = 35),...
Abstract Context There is a medical need for effective insulin-independent antidiabetic drugs that can promote pancreatic β-cell function and have low risk of hypoglycemia in type 2 diabetes mellitus (T2DM) patients. R-form verapamil (R-Vera), which able to enhance the survival β-cells has higher cardiovascular safety margin compared with racemic verapamil, was developed as novel approach T2DM treatment. Objective This randomized, double-blind, placebo-controlled clinical trial designed...
Objective: To assess the changes in static and dynamic balance movement strategies patients with severe osteoporotic vertebral compression fracture while wearing not Knight-Taylor (K-T) spinal brace. Subjects: 47
Summary background Leptin, a recently discovered protein produced in adipocytes, regulates body weight by suppressing food intake and/or increasing energy expenditure. Thyroid hormones, which increase the basal metabolic rate and thermogenesis, have been reported to be one of leptin's regulating factors because alternations thyroid status might lead compensatory changes circulating leptin. objective The aim this study was assess influence sequential function on serum leptin levels. patients...
Objective: To investigate the usefulness of whole body scan (WBS) and serum thyroglobulin (Tg) measurement after thyroxine withdrawal during sequential follow-ups in patients with differentiated thyroid cancer (DTC). Design: Two hundred sixty-five consecutive DTC were enrolled. They previously treated near-total thyroidectomy I-131 remnant ablation, without initial metastases or Tg antibodies. All had first follow-up WBS 6–12 months treatment, 165 received second further therapy....
Background . To differentiate gastric motility and sensation between type II diabetic patients controls explore different expressions of peptides. Methods Eleven health volunteers similar age body mass index were invited. All underwent transabdominal ultrasound for visual analogue scales. Blood samples taken glucose plasma peptides (ghrelin, motilin, glucacon-like peptides-1) by ELISA method. Results Gastric emptying was significantly slower in than (T50: 46.3 (28.0–52.3) min versus 20.8...
The objectives of this study were to evaluate the associations between clinical parameters and quality life (QOL) patients with acromegaly in Taiwan identify impacts hormone control, regimens, or co-morbidities on acromegalic patients' daily life.From 2013 2015, subjects recruited through five medical centers. Clinical data recorded. QOL enrolled assessed by using Acromegaly Quality Life Questionnaire (AcroQoL).This 272 (117 males, 155 females). Remission, defined normalization IGF-1, had...
Diabetic macrovascular complications contribute to nonignorable causes of morbidity and mortality in patients with diabetes mellitus (DM). In this study, the trends risk factors were examined DM Taiwan.Health care information International Classification Diseases, Ninth Revision diagnostic codes retrieved from Taiwan Bureau National Health Insurance claims files between 2005 2014. Using these data, number cases annual prevalence diabetic individuals stratified by age sex.The either stroke or...
Abstract Introduction The sural sensory nerve action potential (SNAP) amplitude is a measure of the number axons. We tested hypothesis that SNAP can be used as marker in screening, severity evaluation, and follow‐up diabetic distal symmetrical polyneuropathy (DSPN). Methods Patients with type 2 diabetes underwent conduction studies were followed for 6 years. Composite scores (CASs) determined to evaluate DSPN severity. Results Sural amplitudes negatively correlated CAS ( r = −.790, P <...
No study has evaluated whether subnormal estimated glomerular filtration rate (eGFR) (between 61 and 90 mL/min) high normal albumin–creatinine ratio (ACR) (<30 mg/g) are associated with cardiovascular (CV) events mortality in type 2 diabetic (T2DM) patients normoalbuminuria. We observed a longitudinal cohort of 1291 T2DM normoalbuminuria who were receiving intensified multifactorial treatment from 2004 to 2008. Cox regression models used evaluate eGFR ACR as the risk factors major CV...