A5057584898- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Adipose Tissue and Metabolism
- Neuroscience and Neuropharmacology Research
- Metabolism and Genetic Disorders
- Epilepsy research and treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Ischemic Stroke Management
- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Cancer, Hypoxia, and Metabolism
- Pharmacological Effects and Toxicity Studies
- Metabolomics and Mass Spectrometry Studies
- Sirtuins and Resveratrol in Medicine
- Endoplasmic Reticulum Stress and Disease
- Peroxisome Proliferator-Activated Receptors
- S100 Proteins and Annexins
- PARP inhibition in cancer therapy
- RNA regulation and disease
- Sphingolipid Metabolism and Signaling
- Antiplatelet Therapy and Cardiovascular Diseases
- Calpain Protease Function and Regulation
- Genetics and Neurodevelopmental Disorders
- ATP Synthase and ATPases Research
- Cerebrovascular and Carotid Artery Diseases
Chang Gung University
2014-2024
Kaohsiung Chang Gung Memorial Hospital
2013-2024
Institute for Biomedicine
2016-2019
Shanghai Jiao Tong University
2011-2018
Ruijin Hospital
2011-2018
Guangdong Pharmaceutical University
2015
Southern Medical University
2015
Shanghai Institutes for Biological Sciences
2014
Chang Gung Memorial Hospital
1988-2011
Neurology, Inc
2005
Long-term therapy with antiepileptic drugs (AEDs) has been associated metabolic consequences that lead to an increase in risk of atherosclerosis patients epilepsy. We compared the long-term effects monotherapy using different categories AEDs on markers vascular and atherosclerotic process.One hundred sixty adult who were receiving AED monotherapy, including two enzyme-inducers (carbamazepine, CBZ; phenytoin, PHT), enzyme-inhibitor (valproic acid, VPA), a noninducer (lamotrigine, LTG) for...
To evaluate cognitive impairment (CI) in rural China using the Chinese version of Mini-Mental Status Examination (CMMSE) and compare prevalence CI two different cutoff points.A population-based survey was conducted 2809 people aged 60 years above a community towns (Huaxin Xujing) Qingpu district, located western suburb Shanghai. Face-to-face interviews were carried out to collect relevant information with questionnaires. The State either 23/24 point or varying according education level (AEL)...
Parkinson disease (PD) is a complex neurodegenerative disorder characterized by progressive loss of dopaminergic neurons. Mitochondrial dysfunction, oxidative stress or protein misfolding and aggregation may underlie this process. Autophagy an intracellular catabolic mechanism responsible for degradation recycling damaged proteins cytoplasmic organelles. Autophagic dysfunction hasten the progression neuronal degeneration. In study, resveratrol promoted autophagic flux protected neurons...
Hypertensive intracerebral hemorrhage (HICH) is generally considered to be a monophasic event. Enlargement of the initial hematoma after several hours or days has rarely been documented. We describe clinical and CT findings in 8 patients (5 men, 3 women, aged 39 68 years) with continued bleeding rebleeding during acute phase HICH. The thalamus was most frequent site (6/8). neurologic status deteriorated all: 6 within 24 hours, 2 5 7 days. Persistent hypertension common (6/8) prior extension...
Mitochondrial dysfunction and oxidative stress are underlying contributors to Parkinson's disease (PD). The reduction of aberrant proteins dysfunctional mitochondria through constitutive autophagy is essential for neuronal survival. We investigated the neuroprotective effects natural red wine extract, resveratrol, on Complex I inhibitor, rotenone-induced SH-SY5Y cellular model. With rotenone exposure, reactive oxygen species (ROS), apoptosis cell death increased at both 6 18 h; same time,...
Status epilepticus may decrease mitochondrial biogenesis, resulting in neuronal cell death occurring the hippocampus. Sirtuin 1 (SIRT1) functionally interacts with peroxisome proliferator-activated receptors and γ coactivator 1α (PGC-1α), which play a crucial role regulation of biogenesis. In Sprague-Dawley rats, kainic acid was microinjected unilaterally into hippocampal CA3 subfield to induce bilateral seizure activity. SIRT1, PGC-1α, other key proteins involving biogenesis amount DNA were...
Insoluble fibrils of amyloid-β peptide (Aβ) are the major component senile and vascular plaques found in brains Alzheimer9s disease (AD) patients. Aβ has been implicated neuronal degeneration because its toxicity to neurons endothelial cells <i>in vitro</i>; some these die with characteristic features apoptosis. We used primary cultures murine cerebral (CECs) explore mechanisms involved Aβ−induced cell death. report here that Aβ<sub>25–35</sub>, a cytotoxic fragment Aβ, induced translocation...
<h3>Background</h3> A T-to-C transition at mitochondrial DNA (mtDNA) nucleotide position 16189 can generate a variable length polycytosine tract (poly-C). This variance has been associated with disease. suggested pathogenesis is that it interferes the replication process of mtDNA, which in turn decreases mtDNA copy number and generates <h3>Methods</h3> In this study, 837 healthy adults9 blood samples were collected determined for their D-loop sequence. The leucocytes serum levels oxidative...
Both the coding and control regions of mitochondrial DNA (mtDNA) play roles in generation diabetes; however, no studies have thoroughly reported on combined diabetogenic effects variants two regions. We determined haplogroup mtDNA sequence region 859 subjects with diabetes 1,151 normoglycemic subjects. Full-length sequences were conducted 40 harboring specific diabetes-related haplogroups. Multivariate logistic regression analysis adjustment for age, sex, BMI revealed that B4 significant...
Parkinson’s disease (PD) is a progressive neurological disorder marked by nigrostriatal dopaminergic degeneration. Evidence suggests that mitochondrial dysfunction may be linked to PD through variety of different pathways, including free-radical generation and the Complex I activity. In Lewis rats, chronic systemic administration specific inhibitor, rotenone (3 mg/kg/day) produced parkinsonism-like symptoms. Increased oxidized proteins peroxynitrite, or cytosol translocation Bim, Bax...
Glucagon-like peptide-1 (GLP-1) is an intestinal-secreted incretin that increases cellular glucose up-take to decrease blood sugar.Recent studies, however, suggest the function of GLP-1 not only sugar, but also acts as a neurotrophic factor plays role in neuronal survival, neurite outgrowth, and protects synaptic plasticity memory formation from effects β-amyloid.Oxidative DNA damage occurs during normal neuron-activity many neurological diseases.Our study describes how affected ability...