A5084762687- Parathyroid Disorders and Treatments
- Thyroid and Parathyroid Surgery
- Thyroid Cancer Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Gallbladder and Bile Duct Disorders
- Genetic Syndromes and Imprinting
- Medical Imaging and Pathology Studies
- Neuroendocrine Tumor Research Advances
- Gastrointestinal disorders and treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Biliary and Gastrointestinal Fistulas
- Pancreatic and Hepatic Oncology Research
- Bone health and treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Tracheal and airway disorders
- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Sarcoma Diagnosis and Treatment
- Amoebic Infections and Treatments
- Pancreatitis Pathology and Treatment
- Head and Neck Anomalies
- Bone health and osteoporosis research
- Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Thyroid Disorders and Treatments
Kaohsiung Chang Gung Memorial Hospital
2014-2024
Memorial Hospital of South Bend
1991-2024
Chang Gung University
2012-2023
E-Da Hospital
2012
Chang Gung Memorial Hospital
1983-2009
National Taiwan University
2009
Kaohsiung Municipal Kai-Syuan Psychiatric Hospital
2005
I-Shou University
2005
National Sun Yat-sen University
2004
Background: Papillary thyroid carcinoma (PTC) are clinicopathogenetically heterogeneous. Micro-RNAs (miRNAs) involved in the pathogenesis of diverse human cancers, including PTC. Information regarding associations between clinicopathological features PTC with expression specific miRNAs, however, is sparse. In this study, we compared deregulated miRNAs PTCs to assess was associated selected clinicopathogenetic features. Methods: We analyzed levels three reported (miR-221, miR-222, and...
Recent studies suggest that miR-146b deregulation in papillary thyroid carcinoma (PTC) was associated with advanced tumor characteristics. However, the influence of expression on prognosis PTC remains unknown. We sought to correlate levels a previously reported cohort and reveal underlying mechanisms via cell line model. Expression were assessed quantitative real-time PCR 71 cases distinct clinico-pathogenetic All patients classified into disease-free or active disease group, based their...
Summary Objective Genetic alterations in four oncogenes, namely RAS point mutations, RET rearrangements ( /PTC), NTRK1 TRK ) and BRAF mutations have been identified human papillary thyroid carcinomas (PTCs). These oncogenes act along the RET/PTC(TRK)–RAS–BRAF–MEK–MAPK kinase pathway, mediating a number of cellular fates including growth, proliferation survival cells. In this study, we analysed cohort PTCs. Methods To screen for genomic DNA 105 PTCs were amplified by polymerase chain reaction...
Abstract Five cases of intrahepatic cholangiocarcinoma were found among 101 hepatolithiasis. There was no definite sign in ERCP and image studies four cases. The possibility the existence occult should be kept mind, especially when unusual presentations, such as body weight loss, anemia, palpable abdominal mass, intractable pain, appear. An intraoperative frozen‐section examination considered under following circumstances: (1) whitish nodular mass over liver, (2) mucinous substance within...
Hepatocyte growth factor (HGF) has been reported the cause of many biological events, including cell proliferation, movement, invasiveness, morphogenesis, and angiogenesis. Elevated hepatocyte content in tumor tissue was to predict a more aggressive biology non-small lung cancer patients. However, there is still limited knowledge about role HGF breast cancer. This study designed with aim elucidate possible relationship between preoperative circulating soluble cancer.One hundred twenty-four...
Transoral Endoscopic Thyroidectomy Vestibular Approach (TOETVA) is a novel technique with better cosmetic results. However, extraction of large malignant thyroid nodule from the central incision TOETVA necessitates breaking it into pieces to avoid mental nerve injury, situation that may violate proper oncological surgery. In this study, we sought appropriate nodular diameter in cancer be removed an intact status through technique. A total 27 cases nodules were operated using Aug 2016 July...
<h3>Hypothesis</h3> Secondary hyperparathyroidism decreases renal clearance of parathyroid hormone (PTH). <h3>Objective</h3> To determine whether rapid PTH assays can be used to predict the success a total parathyroidectomy treat symptomatic secondary hyperparathyroidism. <h3>Design</h3> Case series from August 1 December 31, 2000. <h3>Setting</h3> Tertiary referral center. <h3>Participants</h3> Patients with (n = 24) who underwent and autotransplantation were included in study....
MicroRNA (miR)-146b is overexpressed in papillary thyroid carcinoma (PTC) and associated with extrathyroidal invasion, advanced tumor stage, poor prognosis. However, the underlying mechanism of miR-146b relation to its oncogenic behavior PTC putative targets remain unknown.The purpose was investigate IL-1 receptor-associated kinase 1 (IRAK1) as potential target gene involvement PTC.We used genome-wide microarray, computational analysis, 3' UTR reporter assays identify IRAK1 a gene. In vitro...
Objective To conduct a retrospective study of 15 patients with persistent (n = 4) and recurrent 11) hyperparathyroidism. Summary Background Data Secondary hyperparathyroidism may persist or recur because hyperfunction the parathyroid remnant transplanted tissue. It is great challenge to localize tissue either in neck at arm before surgery. Methods From June 1994 2000, secondary were selected for surgery removal The indications included bone pain, hypercalcemia, general weakness, skin...
Abstract Intrahepatic cholangiocarcinoma is a rare disease. The prognostic factors of resectable have not been previously reported. Nineteen patients (10M, 9F) with were investigated to find that might influence prognosis. cumulative survival rate was measured using the Kaplan‐Meier method. log‐rank test used compare two survivals. Age, sex, tumor size, and positive tissue carcinoembryonic antigen had no on Patients HLA‐DR, well‐differentiated carcinoma, clear resective margin better...
Chromosome 9 is frequently deleted in high-risk gastrointestinal stromal tumors (GISTs), whereas its specific tumor suppressor genes (TSGs) are less understood. We did an integrative study of MTAP gene at 9p21 to analyze implication GISTs.To search TSGs on chromosome 9, we used ultrahigh-resolution array comparative genomic hybridization profile DNA copy number alterations 22 GISTs, with special attention gene. immunoexpression was assessable for 306 independent GISTs tissue microarrays, 146...
To determine the role of postmastectomy radiotherapy (PMRT) in breast cancer patients with T1-2 and N1 disease.A total 207 women were enrolled. The 5-year Kaplan-Meier estimates locoregional recurrence rate (LRR), distant (DRR) overall survival (OS) analyzed by different tumor characteristics. Multivariate analyses performed using Cox proportional hazards modeling.With median follow-up 59.5 months, LRR, DRR OS 9.1%, 20.3% 84.4%, respectively. On univariate analysis, age < 40 years old (p =...
<h3>Hypothesis</h3> The recovery of osteoporosis or bone mineral density (BMD) after parathyroidectomy and autotransplantation can be improved in patients with symptomatic secondary hyperparathyroidism. <h3>Design</h3> Case series. <h3>Setting</h3> Tertiary referral center. <h3>Patients</h3> Forty-five hyperparathyroidism who underwent total were included. They divided into an osteoporotic group (n = 20) a nonosteoporotic 25) according to preoperative T scores less than −2.5 at either the...