A5090368941- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Genetic Associations and Epidemiology
- Nutritional Studies and Diet
- Cytokine Signaling Pathways and Interactions
- Obesity, Physical Activity, Diet
- Venous Thromboembolism Diagnosis and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Cellular Mechanics and Interactions
- Adipose Tissue and Metabolism
- Bioinformatics and Genomic Networks
- DNA Repair Mechanisms
- Microtubule and mitosis dynamics
- Hypothalamic control of reproductive hormones
- Diet and metabolism studies
- Nuclear Receptors and Signaling
- Galectins and Cancer Biology
- Microbial Metabolites in Food Biotechnology
- Antimicrobial Peptides and Activities
- Nicotinic Acetylcholine Receptors Study
- Neurogenetic and Muscular Disorders Research
- Microbial Metabolic Engineering and Bioproduction
- Lipid metabolism and disorders
- Posttraumatic Stress Disorder Research
Second Affiliated Hospital of Xi'an Jiaotong University
2022-2024
Xi'an Jiaotong University
2018-2024
First Affiliated Hospital of Xi'an Jiaotong University
2023
Chi Mei Medical Center
2005
Harvard University
1994-2002
Massachusetts Eye and Ear Infirmary
2002
National Center for Toxicological Research
1989
Abstract Background The incidence of pulmonary embolism complications in the literature ranges from 10 to 50%, with a 0.5–10% risk fatal embolism. However, biological cause is unknown. Methods This study used data Genome-Wide Association Study (GWAS) Pulmonary Embolism and Human Blood Metabolites UK Biobank, subjects European ancestry were analyzed. We explored relationship between blood metabolites three ways. first analyzed genetic correlation human using linkage disequilibrium score...
Osteoarthritis (OA), the most common type of arthritis, is an age-associated disease, characterized by progressive degradation articular cartilage, synovial inflammation, and degeneration subchondral bone. Chondrocyte proliferation regulated Indian hedgehog (IHH in humans, Ihh animals) signaling molecule, which regulates hypertrophy endochondral ossification development skeletal system. microRNAs (miRNAs, miRs) are a family about 22-nucleotide endogenous non-coding RNAs, negatively regulate...
The aim of the present study was to elucidate evolutionary trajectory colon cells from normal mucosa, adenoma, then carcinoma in same microenvironment. Normal colon, adenoma and tissues patient were analyzed by single-cell sequencing, which perfectly simulated process time-dependent cancer due A total 22 cell types identified. Results suggest presence dominant clones including C2 goblet cell, epithelial subtype 1 (Epi1), enterocyte subset 0 (Entero0), Entero5 carcinoma. Epi1 Entero0...
Introduction Colorectal cancer (CRC) is a serious threat to human health. Screening new biomarkers can provide basis for improving the prognosis and individualized treatment of CRC. Although some members defensin family were found increased in pancreatic CRC, their exact function clinical significance remain unclear. Methods In this study, expression, correlation, mutation, functional enrichment several CRC analyzed using tumor public databases verified patients. Results showed no...
Abstract Aims Classification of spinal muscular atrophy (SMA) is associated with the clinical prognosis; however, objective classification markers are scarce. This study aimed to identify metabolic in cerebrospinal fluid (CSF) children SMA types II and III. Methods CSF samples were collected from 40 patients (27 type 13 III) analyzed for metabolites. Results We identified 135 metabolites These lysine degradation arginine, proline, tyrosine metabolism. seven Hammersmith Functional Motor...
Abstract Epilepsy is a severe neurological condition affecting 50–65 million individuals worldwide that can lead to brain damage. Nevertheless, the etiology of epilepsy remains poorly understood. Meta-analyses genome-wide association studies involving 15,212 cases and 29,677 controls ILAE Consortium cohort were used conduct transcriptome-wide (TWAS) protein-wide (PWAS). Furthermore, protein-protein interaction (PPI) network was generated using STRING database, significant...
Drug treatment of metabolic associated fatty liver disease (MAFLD) remains lacking. This study analyzes the efficacy and mechanism underlying intermittent fasting combined with lipidomics. Thirty-two male rats were randomly divided into three groups: Normal group, administered a standard diet; MAFLD 60% high-fat time-restricted feeding (TRF) diet. Eating was allowed for 6 h per day (16:00-22:00). After 15 weeks, lipidomics other indicators compared. A total 1,062 metabolites detected....
The Food Frequency Questionnaire (FFQ) is often used to assess dietary intake in large-scale epidemiological studies. This study aimed evaluate the reproducibility and validity of FFQ newly developed for children aged 6 12 western China. A total 133 were included analysis, all their caregivers completed FFQs twice with a three-month interval period, three 24 h recalls carried out one month after first FFQ. We assessed relative using various methods, such as Spearman correlation coefficient,...
The main treatments for Parkinson’s disease (PD) currently include surgery, rehabilitation, and most commonly, drug therapy. However, the drugs that are used to treat PD provide only symptomatic relief delayed progression but have no curative effect cause many adverse reactions. When considering pathogenic factors metabolic regulation, type 2 diabetes a high rate of comorbidity; this provides theoretical basis treatment with first-line antidiabetic drugs. Among these agents, metformin...
Abstract Introduction Stromal cell-derived factor-1 (SDF-1) is a newly discovered small molecule adipocytokine, and research has shown that it closely related to the occurrence development of obesity. However, there are currently few reports on SDF-1 in childhood obesity nonalcoholic fatty liver disease (NAFLD), this study aims explore relationship between indicators obese children. Methods Serum concentrations were measured using enzyme-linked immunosorbent assay (ELISA). Clinical...
Genetic risk score (GRS, also known as polygenic score) analysis is an increasingly popular method for exploring genetic architectures and relationships of complex diseases. However, diseases are usually measured by multiple correlated phenotypes. Analyzing each disease phenotype individually likely to reduce statistical power due testing correction. In order conquer the disadvantage, we proposed a principal component (PCA)-based GRS approach. Extensive simulation studies were conducted...
To explore the clinical and prognostic features of CVT caused by PROS1 gene mutations to provide experience for new oral anticoagulants, such as rivaroxaban, in treatment with a high risk thrombosis.The patient's symptoms were described, brain imaging blood coagulation tests performed confirm diagnosis CVT. The family members recruited receive ultrasonic examination lower limb vessels. Genetic analysis on pedigree was carried out identify responsible PS deficiency. We followed-up this...
Abstract Aim Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease of childhood, with genetic susceptibility and pathological processes such as autoimmunity autoinflammation, but its pathogenesis unclear. We conducted a transcriptome-wide association study (TWAS) using expression interpolation from large-scale genome-wide (GWAS) dataset to identify genes, biological pathways, environmental chemicals associated JIA. Methods obtained published GWAS data on JIA for...
Menarche is the first occurrence of menstrual bleeding and one most important events female puberty. Alarmingly, over last several decades, mean age at menarche (AAM) has decreased. Environmental endocrine disruptors (EEDs) are chemicals that may interfere with system, resulting in adverse developmental, immunological, neurological, reproductive effects humans. Thus, EEDs on fertility reproduction growing concerns modern societies. In this study, we aimed to determine influence genetic...
Celiac disease (CeD) is one of the most common intestinal inflammatory diseases, and its incidence prevalence have increased over time. CeD affects multiple organs systems in body, environmental factors play a key role complex pathogenesis. Although gluten exposure known to be causative agent, many unknown can trigger or exacerbate CeD. In this study, we investigated influence genetic on Data from genome-wide association study that included 12,041 cases 12,228 controls were used conduct...
Background Gut microbiota and obesity are deeply interconnected. However, the causality in relationship between these factors remains unclear. Therefore, this study aimed to elucidate genetic gut childhood obesity. Methods Genetic summary statistics for were obtained from MiBioGen consortium. Genome-wide association studies (GWAS) data North American, Australian, European collaborative genome-wide meta-analyses. Mendelian randomization (MR) analyses performed using inverse variance weighting...
Diet is an important factor influencing central precocious puberty (CPP). This study aimed to investigate the relationship among diet quality, pro-inflammatory diets, and CPP in Chinese girls.