A5036348972- Glioma Diagnosis and Treatment
- Nutritional Studies and Diet
- Ferroptosis and cancer prognosis
- Adipose Tissue and Metabolism
- Medical Coding and Health Information
- Single-cell and spatial transcriptomics
- MicroRNA in disease regulation
- Mitochondrial Function and Pathology
- Diet and metabolism studies
- Pituitary Gland Disorders and Treatments
- Fatty Acid Research and Health
- Nuclear Receptors and Signaling
- Chronic Disease Management Strategies
- Birth, Development, and Health
- Extracellular vesicles in disease
- Tea Polyphenols and Effects
- Cancer-related molecular mechanisms research
- Parkinson's Disease Mechanisms and Treatments
- Cancer Cells and Metastasis
- Chromatin Remodeling and Cancer
- Lymphatic System and Diseases
- Atherosclerosis and Cardiovascular Diseases
- Down syndrome and intellectual disability research
- Obesity, Physical Activity, Diet
- Cancer, Hypoxia, and Metabolism
Second Affiliated Hospital of Xi'an Jiaotong University
2022-2024
Air Force Medical University
2024
Xi'an Jiaotong University
2019-2023
Isocitrate dehydrogenase (IDH) mutations occur frequently in lower-grade gliomas, which result genome-wide epigenetic alterations. The wild-type IDH1 is reported to participate lipid biosynthesis and amino acid metabolism, but its role tumorigenesis still unclear. In this study, the expressions of podoplanin (Pdpn) were determined IDH-mutated IDH-wild-type their relationships glioma further analyzed. addition, regulation mutant on Pdpn expression was investigated by luciferase assays...
This study aimed to determine Down syndrome (DS) burden using years lived with disability (YLDs), of life lost (YLLs), disability-adjusted (DALYs), and the trends in these parameters.We obtained annual YLDs, YLLs, DALYs, age-standardized rates (ASRs) DS from 2010 2019 Global Health Data Exchange tool. The estimated percentage changes (EAPCs) ASR were used quantify evaluate trends. Gaussian-process regression Pearson's correlation coefficient assess relationship between socio-demographic...
Ischemic stroke (IS) is a fatal neurological disease that occurs when the blood flow to brain disrupted, leading tissue damage and functional impairment. Cellular senescence, vital characteristic of aging, associated with poor prognosis for IS. This study explores potential role cellular senescence in pathological process following IS by analyzing transcriptome data from multiple datasets (GSE163654, GSE16561, GSE119121, GSE174574). By using bioinformatics methods, we identified...
The main treatments for Parkinson’s disease (PD) currently include surgery, rehabilitation, and most commonly, drug therapy. However, the drugs that are used to treat PD provide only symptomatic relief delayed progression but have no curative effect cause many adverse reactions. When considering pathogenic factors metabolic regulation, type 2 diabetes a high rate of comorbidity; this provides theoretical basis treatment with first-line antidiabetic drugs. Among these agents, metformin...
Background: Low grade gliomas(LGGs) present vexatious management issues for neurosurgeons. Chromatin regulators (CRs) are emerging as a focus of tumor research due to their pivotal role in tumorigenesis and progression. Hence, the goal current work was unveil function value CRs patients with LGGs. Methods: RNA-Sequencing corresponding clinical data were extracted from The Cancer Genome Atlas (TCGA) Chinese Glioma (CGGA) database. A single-cell RNA-seq dataset sourced Gene Expression Omnibus...
Isocitrate dehydrogenase (IDH) mutations frequently occur in lower-grade gliomas and secondary glioblastomas. Mutant IDHs exhibit a gain-of-function activity, leading to the production of D-2-hydroxyglutarate (D-2HG) by reducing α-ketoglutarate (α-KG), central player metabolism epigenetic modifications. However, role α-KG homeostasis IDH-mutated gliomagenesis remains elusive. In this study, we found that low expression oxoglutarate (OGDH) was common feature gliomas, as well astrocytes. This...
Abstract Purpose Patients with CNS tumors is affected by many characteristics. Socioeconomic status (SES) has been found to affect tumors’ survival. This study focuses on the influence of SES in tumor. Methods Patient data were extracted from Surveillance, Epidemiology, and End Results database. Supervised optimal binning information value (IV) used for assessment. Kaplan-Meier, Cox regression, area under curve (AUC) net reclassification improvement (NRI) assess predictive performance....
Ischemia stroke and epilepsy are two neurological diseases that have significant patient societal burden, with similar symptoms of deficits. However, the underlying mechanism their co-morbidity still unclear. In this study, we performed a combined analysis six gene expression profiles (GSE58294, GSE22255, GSE143272, GSE88723, GSE163654, GSE174574) to reveal common mechanisms IS epilepsy. mouse datasets, 74 genes were co-upregulated 7 co-downregulated in groups. Further revealed co-expressed...
Background: Melatonin is able to alleviate the intracerebral hemorrhage (ICH), but its detail functions are poorly understood. As an iron-contained compound in hemoglobin, heme involved nerve injury after ICH. In this study, we aimed investigate roles and mechanism of melatonin heme-induced Methods: C57BL/6 mice were intracranially injected with heme, then received treatment. Behavior Tests (mNSS, forelimb placing corner turn tests), H&E staining, Nissl Staining Prussian Blue recuited...
Introduction Take-away milk tea (TAMT) is popular among young generation, and the numbers of retails TAMT have increased dramatically in recent years many cities China. Non-dairy cream one major ingredients TAMT. Concerns been raised whether trans-fat originated from non-dairy may an influence on cardio-metabolic traits. We evaluated associations between daily intake with plasma lipid profiles Chinese adults, who are customers retailers. Materials Methods The study population was phase 1...