A5103112494- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Metastasis and carcinoma case studies
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Sustainable Supply Chain Management
- Environmental Quality and Pollution
- Quality and Supply Management
- Lymphoma Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- CAR-T cell therapy research
- Radiomics and Machine Learning in Medical Imaging
- Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Biomedical Ethics and Regulation
- Animal Nutrition and Physiology
- Gastrointestinal Tumor Research and Treatment
- Neuroblastoma Research and Treatments
- Evaluation and Optimization Models
- Microbial Metabolism and Applications
- Digital Transformation in Industry
- Lung Cancer Research Studies
- Neurofibromatosis and Schwannoma Cases
Xidian University
2022-2023
Center for Biologics Evaluation and Research
2023
United States Food and Drug Administration
2023
Zhejiang Gongshang University
2017-2021
Pennsylvania State University
2008-2017
Penn State Milton S. Hershey Medical Center
2014-2016
Northeast Agricultural University
2014-2015
Columbia University Irving Medical Center
2006-2015
Sun Yat-sen University
2015
Montefiore Medical Center
2015
To further understand the molecular pathogenesis of pulmonary sarcomatoid carcinoma (PSC) and develop new therapeutic strategies in this treatment-refractory disease.Whole-exome sequencing a discovery set (n = 10) as well targeted MET mutation screening an independent validation 26) PSC were performed. Reverse transcriptase polymerase chain reaction Western blotting performed to validate exon 14 skipping. Functional studies for oncogenic roles skipping conducted lung adenosquamous cell line...
Rationale: Oxidants are believed to play a major role in the development of emphysema.Objectives: This study aimed determine if expression human copper–zinc superoxide dismutase (CuZnSOD) within lungs mice protects against emphysema.Methods: Transgenic CuZnSOD and littermate were exposed cigarette smoke (6 h/d, 5 d/wk, for 1 yr) compared with nonexposed mice. A second group was treated intratracheal elastase induce emphysema.Measurements: Lung inflammation measured by cell counts...
The addition of epidermal growth factor receptor (EGFR) inhibitors to radiotherapy has produced increased locoregional control and reduced mortality from various solid tumors with few additional toxicities. Although anecdotal reports have suggested radiation dermatitis, the overall effect these regimens on dermatologic toxicities not been ascertained.Dermatologic toxicity data were analyzed abstracts presented at annual meetings American Society Clinical Oncology, Therapeutic Radiology...
Perineural invasion (PNI) has been implicated as a poor prognostic indicator in many cancers. The National Comprehensive Cancer Network recommends consideration of observation or adjuvant therapy the presence PNI early colon cancer. These recommendations are based on single institutional studies that fail to evaluate within context chemotherapy. US Database (2004–2012) was reviewed for patients with node negative cancer, and stratified by receipt chemotherapy.Of 21,488 evaluated, 55.2% had...
Matrix metalloproteinase-9 (MMP-9) is hypothesized to facilitate leukocyte extravasation and extracellular remodeling in asthmatic airways. Careful descriptive studies have shown that MMP-9 levels are higher the sputum of asthmatics; however, consequence increased activity has not been determined this disease. We induced asthma transgenic mice express human murine lung tissue macrophage determine direct effect expression on airway inflammation. Transgenic (TG) wild-type (WT) were immunized...
Iron (Fe) is an essential mineral for animal development and function. The present study was carried out to evaluate the effect of replacing FeSO4 with iron glycine chelate (Fe-Gly) in equal Fe level diets on broiler chickens. broilers were randomly allotted 6 dietary treatments 5 replicate pens 10 birds per pen. consisted of: Control group (100 mg from FeSO4/kg diet), Experimental 1 (80 + 20 Fe-Gly/kg 2 (60 40 3 (40 60 4 (20 80 diet). results showed that Fe-Gly did not significantly improve...
We report the case of a young, never-smoker woman with Li-Fraumeni syndrome and advanced lung adenocarcinoma refractory to multiple lines conventional chemotherapy negative for actionable alterations by routine testing. Comprehensive genomic profiling clinical-grade next generation sequencing was performed on 3320 exons 184 cancer-related genes 37 introns 14 frequently rearranged in cancer. The tumor found harbor both EGFR L858R ERBB2 S310F also tested positive known TP53 germline mutation....
Pancreatic cancer remains the tenth most common diagnosis in United States with approximately 48,960 new cases diagnosed 2015 [American Cancer Society, 2015; SEER, 2015]. Unfortunately, pancreatic a deadly and is responsible for fourth largest number of cancer-related deaths. With an estimated 40,560 deaths it second only to lung, prostate, colorectal cancers. patients present advanced disease half have distant metastatic at initial presentation [SEER, Overall survival (OS) poor; 7.2%...
Lymphovascular space invasion (LVSI) of endometrial cancer (EC) is a postoperative histological index, which associated with lymph node metastases. A preoperative acknowledgement LVSI status might aid in treatment decision-making.To explore the utility multiparameter magnetic resonance imaging (MRI) and radiomic features obtained from intratumoral peritumoral regions for predicting endometrioid adenocarcinoma (EEA).A total 334 EEA tumors were retrospectively analyzed. Axial T2-weighted (T2W)...
8020 Background: Pulmonary sarcomatoid carcinoma (PSC) represents a category of highly aggressive carcinomas associated with poor prognosis. New therapeutic strategies based on better knowledge the molecular pathogenesis PSC are needed. We recently identified high frequency unique type MET alterations leading to exon 14 skipping (exon 14Δ) in PSC. Methods: Whole-exome sequencing discovery set and targeted mutation screening an independent validation were performed. RT-PCR Western blotting...
Today, the digital economy has become main theme. The includes industrialization, industrial digitization, governance, and data value. In this context, kinetic energy of factors for economic development. recent years, China's new vehicle industry risen rapidly. 2024 "Global Top 100 Auto Supply Chain", three Chinese enterprises have entered top 20: CATL, Weichai Group, Huayu Automotive. This represents profound accumulation innovation ability component shows indispensable role status in...
We describe a case of schwannomatosis presenting as radicular pain and numbness in multiple nerve distributions. There were peripheral tumors detected by magnetic resonance imaging (MRI) at the left vestibular nerve, cauda equina, right radial thoracic paraspinal brachial plexi. Several resected have features schwannomas, including hypercellular Antoni A areas, hypocellular B Verocay bodies, hyalinized blood vessels. The specimens are also positive for immunohistochemical staining INI1 with...
In China, the government proposes corresponding incentive policies to promote logistics enterprises of green sustainable development. This paper adopts method Combination Fusion Analysis (CFA) towards issues. It initials scheme resource allocation optimization in governmental on supply chain. After reviewing present benefit evaluations, it determines final scheme. The is extended different industry applications. Finally, verified through empirical analysis.
Purpose: Pancreatic cystic lesions are being identified at an increased frequency. However, differentiating between which benign, pre-malignant, or malignant continues to prove difficult. Patients in whom should be assessed for their risk of having developing invasive carcinoma. Identification morphologic characteristics and analysis cyst fluid valuable, but insufficient tools. An objective biomarker could complement histological diagnosis assessing the presence progression cancer. no such...
Abstract Background: Pulmonary sarcomatoid carcinoma (SC) is a rare and highly aggressive lung tumor, it associated with poor prognosis high rate of resistance to conventional chemotherapy. We performed whole-exome next generation sequencing followed by careful ranking validation strategy understand its unique differentiation pattern identify actionable targets. Methods: Twenty-nine patients pulmonary SC diagnosed at our institution between 1998 2013 were enrolled divided into discovery set...