A5078770803- Bladder and Urothelial Cancer Treatments
- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- Cancer survivorship and care
- Breast Cancer Treatment Studies
- Epigenetics and DNA Methylation
- Cancer-related cognitive impairment studies
- Cancer Immunotherapy and Biomarkers
- Multiple and Secondary Primary Cancers
- Cancer Treatment and Pharmacology
- Renal cell carcinoma treatment
- Economic and Financial Impacts of Cancer
- Sarcoma Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- PARP inhibition in cancer therapy
- CAR-T cell therapy research
- Advanced Biosensing Techniques and Applications
- Genetic factors in colorectal cancer
- Biosimilars and Bioanalytical Methods
- Lung Cancer Treatments and Mutations
- Health Systems, Economic Evaluations, Quality of Life
- Pancreatic and Hepatic Oncology Research
- Urinary and Genital Oncology Studies
Pennsylvania State University
2019-2025
Penn State Milton S. Hershey Medical Center
2015-2024
Konica Minolta (Japan)
2019
University of Rochester Medical Center
2019
Lebanon VA Medical Center
2018-2019
Hershey (United States)
2017-2018
Memorial Sloan Kettering Cancer Center
2018
Novartis (United States)
2018
UPMC Central Pa
2018
R&D Systems (United States)
2017-2018
Adolescent/young adult cancer survivors (AYACS) are diagnosed with between 15 and 39 years of age. Improving AYACS' survivorship quality is crucial-including improving social connectedness, a construct describing the quality, structure function relationships. With better understanding network-based interventions can be developed to foster health. This study explored how personal diagnosis impacts connectedness among 35 AYACS 15-25 old. Three themes emerged through thematic analysis: (1)...
Objectives/Goals: This study’s objective was to explore how a personal cancer diagnosis impacts the social connectedness (i.e., quality, structure, and functions of relationships) adolescent/young adult survivors (AYACS, patients diagnosed with between 15 39 years old), inform intervention development fostering health. Methods/Study Population: In this qualitative study (part larger assessing AYACS’ psychosocial challenges), participants were 15–25 old at time within 6 diagnosis....
Metastatic Breast Cancer (MBC) patients often feel their symptom-related needs are unmet, despite visiting doctors up to once a week. Novel approaches needed address symptoms without requiring additional appointments. Technology based symptom management have not been well tested. Nurse AMIE (Addressing Individuals Everyday) is technology supportive care platform that provides guideline-concordant interventions in response patient reported symptoms. We previously successfully implemented...
// Ming Yin 1, 6 , Petros Grivas 2, 7 Hamid Emamekhoo 3 Prateek Mendiratta 2 Siraj Ali 4 JoAnn Hsu 5 Monali Vasekar 1 Joseph J. Drabick Sumanta Pal and Monika Joshi Department of Medicine, Division Hematology-Oncology, Penn State Cancer Institute, Hershey, PA, USA Hematology Medical Oncology, Cleveland Clinic Taussig Clinic, Cleveland, OH, University Wisconsin Carbone Center, WI, Foundation Cambridge, MA, City Hope Comprehensive Duarte, CA, Ohio Columbus, Washington, Seattle, WA,...
Abstract Background DNA damage response (DDR) genomic alterations may play an important role in clinical outcomes of patients with urothelial cancer (UC). However, data on the prognostic DDR gene advanced UC remain unclear. Materials and Methods We retrospectively collected three independent patient cohorts relapsed or including 81 91 from four institutions who underwent FoundationOne sequencing as well 129 selected The Cancer Genome Atlas bladder cohort. Fisher's exact test was used to...
Pancreatic cancer remains the tenth most common diagnosis in United States with approximately 48,960 new cases diagnosed 2015 [American Cancer Society, 2015; SEER, 2015]. Unfortunately, pancreatic a deadly and is responsible for fourth largest number of cancer-related deaths. With an estimated 40,560 deaths it second only to lung, prostate, colorectal cancers. patients present advanced disease half have distant metastatic at initial presentation [SEER, Overall survival (OS) poor; 7.2%...
Patient education materials regarding self-management of chemotherapy-related side effects are limited, which may result in patients using disreputable sources. We created a brochure that educates on common effects, tools to address problems themselves, and guidance when contact their oncologist or seek emergency care. This mixed-methods study conducted at Penn State Cancer Institute evaluates the feasibility an educational improve patient outcomes through education.
Ewing sarcoma (ES) is a highly aggressive malignant bone cancer. ES part of the family tumors (ESFT), which express characteristic t(11;22) translocation as well higher levels CD99. Given that metastasis and tumor burden are significant prognostic factors in patient's response to treatment, prompt diagnosis needed effectively treat ESFT patients. However, challenges classifying characterizing complicate effective management treatment ES. In this report, we present rare case pancreas. Upon...
e19364 Background: Checkpoint Inhibitors (CPI) has revolutionized cancer treatment but financial toxicity can be incurred due to high cost. We performed a population-based analysis examining the cost of CPI vs. conventional chemotherapy (CT) in patients with NSCLC capture real-world value on an individual and community level. Methods: Population based claims database privately insured individuals, MarketScan was interrogated. Pts years 2015 2016 ICD 9 or 10 diagnosis lung who were...
Smoking has been linked to urothelial carcinoma (UC), but the implications on genomic profile and therapeutic response are poorly understood. To determine how smoking history impacts chemotherapy response, clinicopathologic data was collected for patients with metastatic UC (mUC) across 3 academic medical centers comprehensive profiling (CGP) performed through a CLIA-certified lab. Unsupervised hierarchical clustering based status used categorize frequency of alterations (GAs) amongst...
Cancer diagnosis can adversely affect mental well-being and overall clinical outcome. We evaluated the efficacy of a group-led creative writing workshop (CWW) on mood in patients with cancer prospectively. conducted single-institution phase II study. Sixty adult (any type or stage) were randomised 2:1 to CWW (4×CWW sessions, bimonthly over 8 weeks) versus active control (AC) (independent at home help book, four weeks). The total study duration was 6 months follow-up up 3 months. changes...
Abstract Background: Cancer cells have altered metabolism, which contributes to their ability proliferate, survive in unusual microenvironments, and invade other tissues. Measuring the complete set of metabolites an individual (i.e. metabolome) provides a functional readout for cellular pathways. Further, changes metabolome can be correlated with disease status, prognosis progression. Using metabolomics platform machine learning algorithms, biomarker signatures identified predict response...
Micro Abstract: This manuscript reports circulating interleukin 8 (IL-8) biomarker from three large patient cohorts. The study evaluated the clinical utility of higher IL-8 to predict reduced outcome in these 3 analysis represented a variety common solid cancers treated with conventional cancer therapeutics. demonstrates potential as various and immune checkpoint inhibitor therapies. Circulating may therefore be an important companion potentially select patients for IL-8-targeted therapy,...
Abstract Objective: Investigate the interaction of racial disparities on outcomes and toxicities associated with treatment HER2+BrCa (Breast Cancer)- a TrinetX Database study Background: is an aggressive subtype accounting for about 1/3rd all BrCa, which Trastuzumab based therapy remains mainstay treatment. While we are starting to understand breadth in BrCa , knowledge relation HER2+ still limited. Design/Methods: In this propensity score-matched cohort used TriNetX Research Network,...
Abstract Background: Cancer(ca) is a known risk factor for severe COVID-19 (C19) disease, related morbidity, and mortality. Ca patients (pts) were largely excluded from clinical trials evaluating the safety efficacy of 3 FDA-approved C19 vaccines (vax). Breast cancer (Bca) most commonly diagnosed non-skin ca, accounts ~ 30% all new female cancers each year. The pandemic has led to disruptions in Bca care including screening, diagnosis, treatment, follow-up which will likely have an impact on...
1572 Background: Sacituzumab govitecan (SG) is approved in the treatment of metastatic hormone receptor positive and triple negative breast cancer (BC). The efficacy SG across racial subgroups known but no real-world data compares differences toxicities. We aim to expand knowledge about disparities regarding toxicities any ineffective or drug failure. Methods: utilized TriNetX, a multi-health care organization electronic health record database, identify African American (AA) Caucasian (C)...
370 Background: Somatic mutations of ATM are frequently found in UC and have been associated with a better response to cisplatin-based neoadjuvant chemotherapy. However, we previously showed were short survival (PMID: 29682192 ). In this study, focused on prognostic values tumors patients relapsed or advanced (TxN 2-3 M 0-1 ) through three independent datasets. Methods: 81 pts who underwent FoundationOne genomic sequencing (315 cancer-related genes) used as discovery dataset. Results then...
Abstract Background: In MA.31, the lapatinib-taxane combination led to shorter PFS than trastuzumab-taxane in HER2+ metastatic breast cancer. We investigated prognostic and predictive effects of pretreatment serum biomarkers. Methods: MA.31 accrued 652 patients; 537 (82%) were centrally-confirmed HER2+. Biomarkers categorized for univariate multivariate investigations with a median cut-point, ULN cut-points (15 ng/ml- HER2; 506 pg/ml- CAIX; 454 TIMP-1; 1940 pg/ml– uPA; 600 activin A), custom...