A5013952168- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Cancer, Hypoxia, and Metabolism
- Mass Spectrometry Techniques and Applications
- Mitochondrial Function and Pathology
- Gut microbiota and health
- Analytical Chemistry and Chromatography
- Advanced Chemical Sensor Technologies
- Cardiovascular Function and Risk Factors
- Cancer, Lipids, and Metabolism
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Advanced Proteomics Techniques and Applications
- Tryptophan and brain disorders
- Epigenetics and DNA Methylation
- Nutritional Studies and Diet
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Metabolism and Genetic Disorders
- Isotope Analysis in Ecology
- Traditional Chinese Medicine Studies
- Robot Manipulation and Learning
- Air Quality and Health Impacts
- Neuroinflammation and Neurodegeneration Mechanisms
- Spectroscopy and Chemometric Analyses
Arizona State University
1997-2025
Florida International University
2021-2025
Vaccine & Gene Therapy Institute of Florida
2022-2024
Oklahoma Medical Research Foundation
2024
University of Washington
2014-2023
Phoenix (United States)
2019-2023
University of Montana
2023
University of California, San Diego
2023
Brewer Science (United States)
2022
HonorHealth
2021
Summary Chronic caloric restriction (CR) and rapamycin inhibit the mechanistic target of ( mTOR ) signaling, thereby regulating metabolism suppressing protein synthesis. Caloric or extends murine lifespan ameliorates many aging‐associated disorders; however, beneficial effects shorter treatment on cardiac aging are not as well understood. Using a recently developed deuterated‐leucine labeling method, we investigated effect short‐term (10 weeks) CR proteomics turnover remodeling mouse heart....
Alzheimer's disease (AD) risk gene ApoE4 perturbs brain lipid homeostasis and energy transduction. However, the cell-type-specific mechanism of in modulating metabolism is unclear. Here, we describe a detrimental role regulating fatty acid (FA) across neuron astrocyte tandem with their distinctive mitochondrial phenotypes. disrupts neuronal function by decreasing FA sequestering droplets (LDs). FAs LDs are exported internalized astrocytes, diminishing transport efficiency. Further, lowers...
Oncogenic signaling reprograms cancer cell metabolism to augment the production of glycolytic metabolites in favor tumor growth. The ability cells evade immunosurveillance and role metabolic regulators T-cell functions suggest that oncogene-induced reprogramming may be linked immune escape. EGF signaling, frequently dysregulated triple-negative breast (TNBC), is also associated with increased glycolysis. Here, we demonstrated TNBC activates first step glycolysis, but impedes last step,...
Global plastic use has consistently increased over the past century with several different types of plastics now being produced. Much these end up in oceans or landfills leading to a substantial accumulation environment. Plastic debris slowly degrades into microplastics (MPs) that can ultimately be inhaled ingested by both animals and humans. A growing body evidence indicates MPs cross gut barrier enter lymphatic systemic circulation tissues such as lungs, liver, kidney, brain. The impacts...
Colorectal cancer (CRC) is one of the most prevalent and deadly cancers in world. Despite an expanding knowledge its molecular pathogenesis during past two decades, robust biomarkers to enable screening, surveillance, therapy monitoring CRC are still lacking. In this study, we present a targeted liquid chromatography-tandem mass spectrometry-based metabolic profiling approach for identifying biomarker candidates that could highly sensitive specific detection using human serum samples....
Glucose and branched-chain amino acids (BCAAs) are essential nutrients key determinants of cell growth stress responses. High BCAA level inhibits glucose metabolism but reciprocal regulation by has not been demonstrated. Here we show that suppresses catabolism in cardiomyocytes to promote hypertrophic response. CREB stimulated KLF15 transcription resulting downregulation enzymes the pathway. Accumulation through glucose-KLF15-BCAA degradation axis is required for activation mTOR signaling...
Aging | doi:10.18632/aging.100881. Ying Ann Chiao, Stephen C. Kolwicz, Nathan Basisty, Arni Gagnidze, Julia Zhang, Haiwei Gu, Danijel Djukovic, Richard P. Beyer, Daniel Raftery, Michael MacCoss, Rong Tian, Peter S. Rabinovitch
Targeted detection is one of the most important methods in mass spectrometry (MS)-based metabolomics; however, its major limitation reduced metabolome coverage that results from limited set targeted metabolites typically used analysis. In this study we describe a new approach, globally optimized (GOT)-MS, combines many advantages and global profiling metabolomics analysis, including capability to detect unknowns, broad metabolite coverage, excellent quantitation. The key step GOT-MS search...
Mammalian skeletal muscle is broadly characterized by the presence of two distinct categories fibers called type I "red" slow twitch and II "white" fast twitch, which display marked differences in contraction strength, metabolic strategies, susceptibility to fatigue. The relative representation each fiber can have major influences on obesity, diabetes, muscular dystrophies. However, molecular factors controlling specification remain incompletely defined. In this study, we describe control...
Significance In vertebrates, proper patterning during appendage regeneration is regulated by positional memory—a cellular property hypothesized to rely on gradients of molecules present in uninjured limbs. Only one gene, exclusive salamanders, has been shown regulate memory and be expressed a gradient the limb. To identify new candidate effectors memory, we mapped abundance RNAs, proteins, metabolites along zebrafish tail fin. We identified hundreds molecular generated high-confidence list...
Abstract Even in healthy aging, cardiac morbidity and mortality increase with age both mice humans. These effects include a decline diastolic function, left ventricular hypertrophy, metabolic substrate shifts, alterations the proteome. Previous work from our laboratory indicated that short‐term (10‐week) treatment rapamycin, an mTORC1 inhibitor, improved measures of these age‐related changes. In this report, we demonstrate rapamycin‐dependent improvement function is highly persistent, while...
Breast cancer (BC) is a common cause of morbidity and mortality, particularly in women. Moreover, the discovery diagnostic biomarkers for early BC remains challenging task. Previously, we [Jasbi et al. J. Chromatogr. B. 2019, 1105, 26−37] demonstrated targeted metabolic profiling approach capable identifying metabolite marker candidates that could enable highly sensitive specific detection BC. However, coverage this method was limited exhibited suboptimal classification (EBC). To expand...
Abstract The gut microbiome (GM) modulates body weight/composition and gastrointestinal functioning; therefore, approaches targeting resident microbes have attracted considerable interest. Intermittent fasting (IF) protein pacing (P) regimens are effective in facilitating weight loss (WL) enhancing composition. However, the interrelationships between IF- P-induced WL GM unknown. current randomized controlled study describes distinct fecal microbial plasma metabolomic signatures combined IF-P...
The gut microbiota contributes to metabolic disease, and diet shapes the microbiota, emphasizing need better understand how impacts disease via alterations. Fiber intake is linked with improvements in homeostasis rodents humans, which associated changes microbiota. However, dietary fiber extremely heterogenous, it imperative comprehensively analyze impact of various plant-based fibers on an identical setting compare alterations bacterially derived metabolites from different sources....